LOCUS       AJF01393.1               677 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative bifunctional
            penicillin-binding protein 1A/1B PonA1 (murein polymerase)
            (PBP1): penicillin-insensitive transglycosylase (peptidoglycan
            TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
            protein.
ACCESSION   CP007027-49
PROTEIN_ID  AJF01393.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="ponA1"
                     /locus_tag="Y980_0050"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0050, (MTCY21D4.13) Probable
                     ponA1,penicillin-binding protein (class A), bienzymatic
                     protein with transglycosylase and transpeptidase
                     activities (see Graham & Clark-Curtiss 1999), highly
                     similar to many (see Billman-Jacobe et al., 1999). Belongs
                     to the transglycosylase family in the N-terminal section,
                     and to the transpeptidase family in the C-terminal
                     section."
                     /transl_table=11
                     /db_xref="GOA:P71707"
                     /db_xref="InterPro:IPR001264"
                     /db_xref="InterPro:IPR001460"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/Swiss-Prot:P71707"
BEGIN
        1 MVILLPMVTF TMAYLIVDVP KPGDIRTNQV STILASDGSE IAKIVPPEGN RVDVNLSQVP
       61 MHVRQAVIAA EDRNFYSNPG FSFTGFARAV KNNLFGGDLQ GGSTITQQYV KNALVGSAQH
      121 GWSGLMRKAK ELVIATKMSG EWSKDDVLQA YLNIIYFGRG AYGISAASKA YFDKPVEQLT
      181 VAEGALLAAL IRRPSTLDPA VDPEGAHARW NWVLDGMVET KALSPNDRAA QVFPETVPPD
      241 LARAENQTKG PNGLIERQVT RELLELFNID EQTLNTQGLV VTTTIDPQAQ RAAEKAVAKY
      301 LDGQDPDMRA AVVSIDPHNG AVRAYYGGDN ANGFDFAQAG LQTGSSFKVF ALVAALEQGI
      361 GLGYQVDSSP LTVDGIKITN VEGEGCGTCN IAEALKMSLN TSYYRLMLKL NGGPQAVADA
      421 AHQAGIASSF PGVAHTLSED GKGGPPNNGI VLGQYQTRVI DMASAYATLA ASGIYHPPHF
      481 VQKVVSANGQ VLFDASTADN TGDQRIPKAV ADNVTAAMEP IAGYSRGHNL AGGRDSAAKT
      541 GTTQFGDTTA NKDAWMVGYT PSLSTAVWVG TVKGDEPLVT ASGAAIYGSG LPSDIWKATM
      601 DGALKGTSNE TFPKPTEVGG YAGVPPPPPS EVPPSETVIQ PTVEIAPGIT IPIGPPTTIT
      661 LAPPPPAPPA ATPTPPP
//