LOCUS       ADD39153.1               858 aa    PRT              VRL 12-OCT-2016
DEFINITION  Human betaherpesvirus 5 tegument protein IRS1 protein.
ACCESSION   GU937742-135
PROTEIN_ID  ADD39153.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
            Herviviricetes; Herpesvirales; Orthoherpesviridae;
            Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE   1  (bases 1 to 235404)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235404)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235404)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Human cytomegalovirus RL11 gene family: variation, recombination
            and transcription
  JOURNAL   Unpublished
REFERENCE   5  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   6  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
  REMARK    Sequence update by submitter
COMMENT     On Oct 12, 2016 this sequence version replaced GU937742.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="Toledo"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="USA"
                     /collection_date="1984"
                     /note="passaged several times in human fibroblasts;
                     contains inversion of 14336 bp region (genes UL128 to
                     UL133); 3 genes are mutated (RL13, UL9 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="IRS1"
                     /note="transcriptional activator; blocks phosphorylation
                     of eIF2alpha and host shutoff of protein synthesis; binds
                     dsRNA; involved in gene regulation; involved in
                     translational regulation; US22 family"
BEGIN
        1 MAQRNGMSPR PPPLGRGRGA GGPSGVGSSP SSSCVPMAAT STAGTGASTA GSATPAHGVH
       61 RVEPRGPPGA PPGSGNNSNF WHGPERLLLS QIPVERQALT ELEYQAMGAV WRAAFLANST
      121 GRAMRKWSQR DAGTLLPLGR PYGFYARVTP RSQMNGVGAT DLRQLSPRDA WIVLVATVVH
      181 EVDPAADPTV GDKAGHPEGL CAQDGLYLAL GAGFRVFVYD LANNTLILAA RDADEWFRHG
      241 AGEVVRLYRC NRLGVGTPRA TLLPQPALRQ TLLRAEEATA LGRELRRRWA GTTVALQTPG
      301 RRLQPMVLLG AWQELAQYEP FASAPHPASL LTAVRRHLNQ RLCCGWLALG AVLPARWLGC
      361 AAGPAGPATG TAAGTTTMTA GTTLPAGASG TETEAAGGDA PCAMAGAVGS AVPVPPQPYG
      421 ASAGGNAVCV PNADAHAVVG ADAAAAVAAP TVLVGPTAMA GPAASGTVPR AMLVVVLDEL
      481 GAVFGYCPLD GHVYPLAAEL SHFLRAGVLG ALALGRESAP AAEAARRLLP ELDREQWERP
      541 RWDALHLHPR AALWAREPHG QWEFMFREQR GDPINDPVAF RVSDARTLGL DLTTVMTERQ
      601 SQLPEKYIGF YQIRKPPWLM EQPPPPSRQT KPDAATMPPP LSAQASVSYA LRYDDESWRP
      661 LSTVDDHKAW LDLDESHWVL GDSRPDDIKQ RRLLKATQRR GAEIDRPMPV VPEECYDQRF
      721 TTEGHQVIPL CASEPEDDDE DPTYDELPSR PPQKHKPPDK PPRLCKTGPG PPPLPPKQRH
      781 GSTDGKVSAP RQSEHHKRQT RPPRPPPPKF GDRTAAHLSQ NMRDMYLDMC TSSGHRPRPP
      841 APPRPKKCQT HAPHHVHH
//