LOCUS ADD39119.1 739 aa PRT VRL 12-OCT-2016 DEFINITION Human betaherpesvirus 5 multifunctional expression regulator protein. ACCESSION GU937742-64 PROTEIN_ID ADD39119.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235404) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235404) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235404) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Human cytomegalovirus RL11 gene family: variation, recombination and transcription JOURNAL Unpublished REFERENCE 5 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 6 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On Oct 12, 2016 this sequence version replaced GU937742.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Toledo" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="USA" /collection_date="1984" /note="passaged several times in human fibroblasts; contains inversion of 14336 bp region (genes UL128 to UL133); 3 genes are mutated (RL13, UL9 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL69" /note="RNA-binding protein; shuttles between nucleus and cytoplasm; inhibits pre-mRNA splicing; exports virus mRNA from nucleus; exerts most effects post-transcriptionally; involved in gene regulation; involved in RNA metabolism and transport" BEGIN 1 MELHSRGRHD APSLSSLSER ERRARRARRF CLDYEPVPRK FRRERSPTSP STRNGAAASE 61 YHLAEDTVGA ASHHHRPCVP ARRPRYSKDD DTEGDPDHYP PPLPPSSRHA LGGTGGHIIM 121 GTAGFRGGHR ASSSFKRRVA ASASVPLNPH YGKSYDNDDG EPHHHGGDST HLRRRVPSCP 181 TTFGSSHPSS ANNHHGSSAG PQQQQMLALI DDELDAMDED ELQQLSRLIE KKKRARLQRG 241 AASSGTSPSS TSPVYDLQRY TAESLRLAPY PADLKVPTAF PQDHQPRGRI LLSHDELMHT 301 DYLLHIRQQF DWLEEPLLRK LVVEKIFAVY NAPNLHTLLA IIDETLSYMK YHHLHGLPVN 361 PHDPYLETVG GMRQLLFNKL NNLDLGCILD HQDGWGDHCS TLKRLVKKPG QMSAWLRDDV 421 CDLQKRPPET FSQPMHRAMA YVCSFSRVAV SLRRRALQVT GTPQFFDQFD TNNAMGTYRC 481 GAVSDLILGA LQCHECQNEM CELRIQRALA PYRFMIAYCP FDEQSLLDLT VFAGTTTTTA 541 SNHATAGGQQ RGGDQIHPTD EQCANMESRT DPATLTAYDK KDREGSHRHP SPMIAAAPPA 601 QPPSQPQQHY SEGELEEDED SDDASSQDLV RATDRHGDTV VYKTTAVPPS PPAPLAGVRS 661 HRGELNLMTP SPSHGGSPPQ VPHKQPIIPV QSANGNHSTT ATQQQPPPPP VPQEDDSVVM 721 RCQTPDYEDM LCYSDDMDD //