LOCUS ADD39098.1 487 aa PRT VRL 12-OCT-2016 DEFINITION Human betaherpesvirus 5 envelope glycoprotein UL37 protein. ACCESSION GU937742-43 PROTEIN_ID ADD39098.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235404) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235404) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235404) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Human cytomegalovirus RL11 gene family: variation, recombination and transcription JOURNAL Unpublished REFERENCE 5 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 6 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On Oct 12, 2016 this sequence version replaced GU937742.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Toledo" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="USA" /collection_date="1984" /note="passaged several times in human fibroblasts; contains inversion of 14336 bp region (genes UL128 to UL133); 3 genes are mutated (RL13, UL9 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL37" /note="type 1 membrane protein; involved in apoptosis; involved in gene regulation; major isoform (mitochondrial inhibitor of apoptosis, vMIA) encoded by unspliced mRNA" intron_pos 163:2 (1/2) intron_pos 178:0 (2/2) BEGIN 1 MSPVYVNLLG SVGLLAFWYF SYRWIQRKRL EDPLPPWLRR KKACALTRRS RHRLRRQHGV 61 IDGENSETER SVDLVAALLA EAGEESVTED TEREDTEEER EDEEEENEAR TPEVNPIDAE 121 GLSGLAREAC EALKKALRRH RFLWQRRRRA QLLQHNGPQQ SHHAAVFCRV HGLRGFQVSV 181 WLLLTLFWST GYGVSVRCTY HGTDINVTSN ATSMNCLLNC TCNHTQIYNG PCAGAESKLP 241 LNVTFRQSRR QWHSVMLTFG FQYHLEGWFP LRILNESRDI NVTEVYGEVA CFTNDTNITM 301 GQLTLNLTGR SYVLRALART SPFESSVNWE ETNVTDNVTS SENNTVTVMS ILTVYAESDY 361 IFLQDMCPRF LKRSVKLTKN NKKNTTFTGT NMTSLPMWTS ECEGWRYWTT LSIMWKNRRS 421 ALLRAKSRAL GHWALLSICT VAAGSIALLS LFCILLIGLR RDLLEDFRYI CRDEGSSSTK 481 NDVHRIV //