LOCUS       ACS93439.1               847 aa    PRT              VRL 09-MAY-2013
DEFINITION  Human betaherpesvirus 5 tegument protein IRS1 protein.
ACCESSION   GQ221974-136
PROTEIN_ID  ACS93439.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235154)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235154)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235154)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235154)
  AUTHORS   Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
            Wilkinson,G.W. and Tomasec,P.
  TITLE     Characterization of a highly glycosylated form of the human
            cytomegalovirus HLA class I homologue gpUL18
  JOURNAL   J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
   PUBMED   16227221
REFERENCE   5  (bases 1 to 235154)
  AUTHORS   Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
            Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
            Davison,A.J.
  TITLE     Sequences of complete human cytomegalovirus genomes from infected
            cell cultures and clinical specimens
  JOURNAL   J. Gen. Virol. 91 (PT 3), 605-615 (2010)
   PUBMED   19906940
REFERENCE   6  (bases 1 to 235154)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     On or before Aug 17, 2009 this sequence version replaced
            AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
            AY325311.1, DQ195526.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="3157"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="United Kingdom"
                     /collection_date="2001"
                     /note="sequenced at passage 3 in human fibroblasts; three
                     genes are mutated (RL13, UL40 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="IRS1"
                     /note="transcriptional activator; blocks phosphorylation
                     of eIF2alpha and host shutoff of protein synthesis; binds
                     dsRNA; involved in gene regulation; involved in
                     translational regulation; US22 family"
BEGIN
        1 MAQRNGMSPR PPPLGRGRGA GGPSGVGSCS SSVPSTAGTS TSTAGTATPG HGVHRVEPRG
       61 PPGAPPGSGN NSNFWHGPER LLLSQIPVER QALTELEYQA MGAVWRAAFL ANSTARAMRK
      121 WSQRDAGTLL PLGRPYGFYA RVTPRSQMNG VGATDLRQLS PRDAWIVLVA TVVHEVDPAA
      181 DPTVGDKAGH PEGLCAQDGL YLALGAGFRV FVYDLANNTL ILAARDADEW FRHGAGEVVR
      241 LYRCNRLGVG TPRATLLPQP ALRQTLLRAE EATALGRELR RRWAGTTVAL QTPGRRLQPM
      301 VLLGAWQELA QYEPFASAPH PASLLTAVRR HLNQRLCCGW LALGAVLPAR WLGCAAGPAT
      361 GTAAGTTSPT AGTTAMATGT TLLAGASGTE TEAAGGDAPC AMAGAVGSAV PVPPQPYGTS
      421 AGGHAVCVPN AEAHTVVGAD AAAAPTVMVG PAASDTVPRA MLVVVLDELG AVFGYCPLDG
      481 HVYPLAAELS HFLRAGVLGA LALGRESAPA AEAARRLLPE LDREQWERPR WDALHLHPRA
      541 ALWAREPHGQ WEFMFREQRG DPISDPVAFR VSDARTLGLD LTTVMTERQS QLPEKYIGFY
      601 QIRKPPWLME QPPPPSRHTK PDAATMPPPL SAQASVSHAL RYDDESWRPL STVHDHKAWL
      661 DLDESHWVLG DSRPDDIKQR RLLKATQRRG AEIDRPMPVV PEECYDQRFT TEGHQVIPLC
      721 ASEPEDDDED PTYDELPSRP PQKHKPPDKP PRLCKTGPGP PPLPPKQRHG STDGKVSAPR
      781 QSEHHKRQTR PPRPPPPKFG DRTAAHLSQN MRDMYLDMCT SSGHRPRPPA PPRPKKCQTH
      841 APHHVHH
//