LOCUS ACS93432.1 875 aa PRT VRL 09-MAY-2013 DEFINITION Human betaherpesvirus 5 helicase-primase subunit protein. ACCESSION GQ221974-96 PROTEIN_ID ACS93432.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235154) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235154) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235154) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235154) AUTHORS Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H., Wilkinson,G.W. and Tomasec,P. TITLE Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18 JOURNAL J. Gen. Virol. 86 (PT 11), 2999-3008 (2005) PUBMED 16227221 REFERENCE 5 (bases 1 to 235154) AUTHORS Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J., Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and Davison,A.J. TITLE Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens JOURNAL J. Gen. Virol. 91 (PT 3), 605-615 (2010) PUBMED 19906940 REFERENCE 6 (bases 1 to 235154) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK COMMENT On or before Aug 17, 2009 this sequence version replaced AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1, AY325311.1, DQ195526.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="3157" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="United Kingdom" /collection_date="2001" /note="sequenced at passage 3 in human fibroblasts; three genes are mutated (RL13, UL40 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL102" /note="involved in DNA replication" BEGIN 1 MTAQPPLHHR HHPYTLFGTS CHLSWYGLLE ASVPIVQCLF LDLGGGRAEP RLHTFVVRGD 61 RLPPAEVRVV HRASYAALAS AVTTDADERR RGLEQRSAVL ARVLLEGSAL IRVLARTFTP 121 VQIQTDASGV EILEAAPALG VETAALSNAL SLFHVAKLVV IGSYPEVHEP RVVTHAAERV 181 SEEYGTHAHK KLRRGYYAYD LAMSFRVGTH KYVLERDDEA VLARLFEVRE VCFLRTCLRL 241 VTPVGFVAVA VTDEQCCLLL QSAWTHLYDV LFRGFAGQPP LRDYLGPDLF ETGAARSFFF 301 PGFPPVPVYA VHGLHTLMRE TALDAAAEVL SWCGLPDIVG SAGKLEVEPC ALSLGVPEDE 361 WQVFGTEAGG GAVRLNATAF RERPAGGDRR WLLPPLPRDD GDGENNVVEV SSSTGGAHPP 421 SDDATFTVHV RDATLHRVLI VDLVERVLAK CVRARDFNPY VRYSHRLHTY AVCEKFIENL 481 RFRSRRAFWQ IQSLLGYISE HVTSACASAG LLWVLSRGHR EFYVYDGYSG HGPVSAEVCV 541 RTVVDCYWRK LFGGDDPGPT CRVQESAPGV LLVWGDERLV GPFNFFYGNG GAGGSPLHGV 601 VGGFAAGHCG GACCAGCVVT HRHSSGGGGG GSGVGDADHA SGGGLDAAAG SGHNGGSDRV 661 SPSTPPAALG GCCCAAGGDW LSAVGHVLGR LPALLRERVS VSELEAVYRE ILFRFVARRN 721 DVDFWLLRFQ PGENEVRPHA GVIDCAPFHG VWAEQGQIIV QSRDTALAAD IGYGVYVDKA 781 FAMLTACVEV WARELLSSST ASTTTCSSSS VLSSALPSVT SSSSGTATVS PPSCSSSSAT 841 WLEERDEWVR SLAVDAQHAA KRVASEGLRF FRLNA //