LOCUS       ACS93407.1               742 aa    PRT              VRL 09-MAY-2013
DEFINITION  Human betaherpesvirus 5 envelope glycoprotein H protein.
ACCESSION   GQ221974-71
PROTEIN_ID  ACS93407.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235154)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235154)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235154)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235154)
  AUTHORS   Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
            Wilkinson,G.W. and Tomasec,P.
  TITLE     Characterization of a highly glycosylated form of the human
            cytomegalovirus HLA class I homologue gpUL18
  JOURNAL   J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
   PUBMED   16227221
REFERENCE   5  (bases 1 to 235154)
  AUTHORS   Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
            Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
            Davison,A.J.
  TITLE     Sequences of complete human cytomegalovirus genomes from infected
            cell cultures and clinical specimens
  JOURNAL   J. Gen. Virol. 91 (PT 3), 605-615 (2010)
   PUBMED   19906940
REFERENCE   6  (bases 1 to 235154)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     On or before Aug 17, 2009 this sequence version replaced
            AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
            AY325311.1, DQ195526.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="3157"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="United Kingdom"
                     /collection_date="2001"
                     /note="sequenced at passage 3 in human fibroblasts; three
                     genes are mutated (RL13, UL40 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="UL75"
                     /note="type 1 membrane protein; putative membrane fusogen;
                     complexed with envelope glycoprotein L; involved in cell
                     entry; involved in cell-to-cell spread"
BEGIN
        1 MRPGLPSYLI VLAVCLLSHL LSSRYGAKAV SEPLDKAFHL LLNTYGRPIR FLRENTTQCT
       61 YNSSLRNSTV VRENAISFNF FQSYNQYYVF HMPRCLFAGP LAEQFLNQVD LTETLEKYQQ
      121 RLNTYALVSK DLASYRSFSQ QLKAQDSLGE QPTTVPPPID LSIPHVWMPP QTTPHGWTES
      181 HTTSGLHRPH FNQTCILFDG HDLLFSTVTP CLHQGFYLID ELRYVKITLT EDFFVVTVSI
      241 DDDTPMLLIF GHLPRVLFKA PYQRDNFILR QTEKHELLVL VKKDQLNRHS YLKDPDFLDA
      301 ALDFNYLDLS ALLRNSFHRY AVDVLKSGRC QMLDRRTVEM AFAYALALFA AARQEEAGAQ
      361 VSVPRALDRQ AALLQIQEFM ITCLSQTPPR TTLLLYPTAV DLAKRALWTP NQITDITSLV
      421 RLVYILSKQN QQHLIPQWAL RQIADFALKL HKTHLASFLS AFARQELYLM GSLVHSMLVH
      481 TTERREIFIV ETGLCSLAEL SHFTQLLAHP HHEYLSDLYT PCSSSGRRDH SLERLTRLFP
      541 DATVPTTVPA ALSILSTMQP STLETFPDLF CLPLGESFSA LTVSEHVSYV VTNQYLIKGI
      601 SYPVSTTVVG QSLIITQTDS QTKCELTRNM HTTHSITAAL NISLENCAFC QSALLEYDDT
      661 QGVINIMYMH DSDDVLFALD PYNEVVVSSP RTHYLMLLKN GTVLEVTDVV VDATDSRLLM
      721 MSVYALSAII GIYLLYRMLK TC
//