LOCUS       ACS93401.1               746 aa    PRT              VRL 09-MAY-2013
DEFINITION  Human betaherpesvirus 5 multifunctional expression regulator
            protein.
ACCESSION   GQ221974-64
PROTEIN_ID  ACS93401.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235154)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235154)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235154)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235154)
  AUTHORS   Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
            Wilkinson,G.W. and Tomasec,P.
  TITLE     Characterization of a highly glycosylated form of the human
            cytomegalovirus HLA class I homologue gpUL18
  JOURNAL   J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
   PUBMED   16227221
REFERENCE   5  (bases 1 to 235154)
  AUTHORS   Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
            Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
            Davison,A.J.
  TITLE     Sequences of complete human cytomegalovirus genomes from infected
            cell cultures and clinical specimens
  JOURNAL   J. Gen. Virol. 91 (PT 3), 605-615 (2010)
   PUBMED   19906940
REFERENCE   6  (bases 1 to 235154)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     On or before Aug 17, 2009 this sequence version replaced
            AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
            AY325311.1, DQ195526.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="3157"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="United Kingdom"
                     /collection_date="2001"
                     /note="sequenced at passage 3 in human fibroblasts; three
                     genes are mutated (RL13, UL40 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="UL69"
                     /note="RNA-binding protein; shuttles between nucleus and
                     cytoplasm; inhibits pre-mRNA splicing; exports virus mRNA
                     from nucleus; exerts most effects post-transcriptionally;
                     involved in gene regulation; involved in RNA metabolism
                     and transport"
BEGIN
        1 MELHSRGRHD APSLSSLSER ERRARRARRF CLDYEPVPRK FRRERSPTSP STRNGAAASE
       61 YHLAENTVGA ASHHHRPCVP ARRPRYSKDD DTEGDPDHYP PPLPPSSRHA LGGTGGHIIM
      121 GTAGFRGGHR ASSSFKRRVA ASASVPLNPH YGKSHDNDDG EPHHHGGDST HLRRRVPSCP
      181 TTFGSSHPSS ANNHHGSSAG PQQQQMLALI DDELDAMDED ELQQLSRLIE KKKRARLQRG
      241 AASSGTSPSS TSPVYDLQRY TAESLRLAPY PADLKVPTAF PQDHQPRGRI LLSHDELMHT
      301 DYLLHIRQQF DWLEEPLLRK LVVEKIFAVY NAPNLHTLLA IIDETLSYMK YHHLHGLPVN
      361 PHDPYLETVG GMRQLLFNKL NNLDLGCILD HQDGWGDHCS TLKRLVKKPG QMSAWLRDDV
      421 CDLQKRPPET FSQPMHRAMA YVCSFSRVAV SLRRRALQVT GTPQFFDQFD TNNAMGTYRC
      481 GAVSDLILGA LQCHECQNEM CELRIQRALA PYRFMIAYCP FDEQSLLDLT VFAGTTTTTA
      541 SNHATAGGQQ RGGDQIHPTD EQCANMESRT DPATLTAYDK KDREGSHRHP SPMIAAAPST
      601 QPPSQPQQHY SEGELEEDED SDDASSQDLV RATDRHGDTV VYKTTAVPPS PPAPLAGVRS
      661 HRGELNLMTP SPSHGGSPPQ VPHKQPIIPV QSANGNHSTT AIQQQQPPPP PPPPPPPVPQ
      721 EDDSVVMRCQ TPDYEDMLCY SDDMDD
//