LOCUS ACS93397.1 1242 aa PRT VRL 09-MAY-2013
DEFINITION Human betaherpesvirus 5 DNA polymerase catalytic subunit protein.
ACCESSION GQ221974-60
PROTEIN_ID ACS93397.1
SOURCE Human betaherpesvirus 5 (HHV-5)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235154)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235154)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235154)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 4 (bases 1 to 235154)
AUTHORS Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
Wilkinson,G.W. and Tomasec,P.
TITLE Characterization of a highly glycosylated form of the human
cytomegalovirus HLA class I homologue gpUL18
JOURNAL J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
PUBMED 16227221
REFERENCE 5 (bases 1 to 235154)
AUTHORS Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
Davison,A.J.
TITLE Sequences of complete human cytomegalovirus genomes from infected
cell cultures and clinical specimens
JOURNAL J. Gen. Virol. 91 (PT 3), 605-615 (2010)
PUBMED 19906940
REFERENCE 6 (bases 1 to 235154)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
COMMENT On or before Aug 17, 2009 this sequence version replaced
AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
AY325311.1, DQ195526.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="3157"
/isolation_source="urine from a congenitally infected
infant"
/host="Homo sapiens"
/db_xref="taxon:10359"
/country="United Kingdom"
/collection_date="2001"
/note="sequenced at passage 3 in human fibroblasts; three
genes are mutated (RL13, UL40 and UL128);
acronym: HCMV; acronym: HHV-5"
protein /gene="UL54"
/EC_number="2.7.7.7"
/note="involved in DNA replication"
BEGIN
1 MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH
61 KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS
121 PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE
181 PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP
241 LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF
301 DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS
361 GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR
421 LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG
481 SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL
541 QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH
601 YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS
661 NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS
721 LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW
781 VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI
841 GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSTLPEGL ETSSGGLNER
901 RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI
961 CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL
1021 DEVKKYGVPR GFWRILRRLV QARDDLYLHR VCVEDLVLSS VLSKDISLYR QSNLPHIAVI
1081 KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TTGVVSRSDA IDGTDDDADG
1141 GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV
1201 LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC
//