LOCUS       ACS93397.1              1242 aa    PRT              VRL 09-MAY-2013
DEFINITION  Human betaherpesvirus 5 DNA polymerase catalytic subunit protein.
ACCESSION   GQ221974-60
PROTEIN_ID  ACS93397.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235154)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235154)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235154)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235154)
  AUTHORS   Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
            Wilkinson,G.W. and Tomasec,P.
  TITLE     Characterization of a highly glycosylated form of the human
            cytomegalovirus HLA class I homologue gpUL18
  JOURNAL   J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
   PUBMED   16227221
REFERENCE   5  (bases 1 to 235154)
  AUTHORS   Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
            Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
            Davison,A.J.
  TITLE     Sequences of complete human cytomegalovirus genomes from infected
            cell cultures and clinical specimens
  JOURNAL   J. Gen. Virol. 91 (PT 3), 605-615 (2010)
   PUBMED   19906940
REFERENCE   6  (bases 1 to 235154)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     On or before Aug 17, 2009 this sequence version replaced
            AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
            AY325311.1, DQ195526.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="3157"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="United Kingdom"
                     /collection_date="2001"
                     /note="sequenced at passage 3 in human fibroblasts; three
                     genes are mutated (RL13, UL40 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="UL54"
                     /EC_number="2.7.7.7"
                     /note="involved in DNA replication"
BEGIN
        1 MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH
       61 KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS
      121 PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE
      181 PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP
      241 LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF
      301 DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS
      361 GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR
      421 LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG
      481 SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL
      541 QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH
      601 YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS
      661 NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS
      721 LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW
      781 VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI
      841 GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSTLPEGL ETSSGGLNER
      901 RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI
      961 CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL
     1021 DEVKKYGVPR GFWRILRRLV QARDDLYLHR VCVEDLVLSS VLSKDISLYR QSNLPHIAVI
     1081 KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TTGVVSRSDA IDGTDDDADG
     1141 GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV
     1201 LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC
//