LOCUS       ACS93390.1              2240 aa    PRT              VRL 09-MAY-2013
DEFINITION  Human betaherpesvirus 5 large tegument protein protein.
ACCESSION   GQ221974-53
PROTEIN_ID  ACS93390.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
            Betaherpesvirinae; Cytomegalovirus.
REFERENCE   1  (bases 1 to 235154)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235154)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235154)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235154)
  AUTHORS   Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H.,
            Wilkinson,G.W. and Tomasec,P.
  TITLE     Characterization of a highly glycosylated form of the human
            cytomegalovirus HLA class I homologue gpUL18
  JOURNAL   J. Gen. Virol. 86 (PT 11), 2999-3008 (2005)
   PUBMED   16227221
REFERENCE   5  (bases 1 to 235154)
  AUTHORS   Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J.,
            Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and
            Davison,A.J.
  TITLE     Sequences of complete human cytomegalovirus genomes from infected
            cell cultures and clinical specimens
  JOURNAL   J. Gen. Virol. 91 (PT 3), 605-615 (2010)
   PUBMED   19906940
REFERENCE   6  (bases 1 to 235154)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
COMMENT     On or before Aug 17, 2009 this sequence version replaced
            AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1,
            AY325311.1, DQ195526.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="3157"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="United Kingdom"
                     /collection_date="2001"
                     /note="sequenced at passage 3 in human fibroblasts; three
                     genes are mutated (RL13, UL40 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="UL48"
                     /note="complexed with tegument protein UL37;
                     ubiquitin-specific protease (N-terminal region); involved
                     in capsid transport"
BEGIN
        1 MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD AIMEEGARLD
       61 ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA LSRPFNGTTE TCDLDGYMCP
      121 GIFDFLRYAH AKPRPTYVLV TVNSLARAVV FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ
      181 VLMVLTGFGV QLSPAFYYEA LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESAD
      241 TAATTTTAAP SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK
      301 KKPPSTTSKT LATASSSSAI AAASSSSAVP PSYSCGEGAL PALGRYQQLV DEVEQELKAL
      361 TLPPLPANTS AWTLHAAGTE SGANAATATA PSFDEAFLTD RLQQLIIHAV NQRSCLRRPC
      421 GPQSAAQQAV RAYLGLSKKL DAFLLNWLHH GLDLRRMHDY LSHKTTKGTY STLDRALLEK
      481 MQVVFDPYGR QHGPALIAWV EEMLRYVESK PTNELSQRLQ RFVTKRPMPV SDSFVCLRPV
      541 DFQRLTQVIE QRRRVLQRQR EEYHGVYEHL AGLITSIDIH DLDASDLNRR EILKALQPLD
      601 DNAKQELFRL GNAKMLELQM DLDRLSTQLL TRVHNHILNG FLPVEDLKQM ERVVEQVLRL
      661 FYDLRDLKLC DGSYEEGFVV IREQLSYLMT GTVRDNVPLL QEILQLRHAY QQATQQNEGR
      721 LTQIHDLLHV IETLVRDPGS RGSALTLALV QEQLAQLEAL GGLQLPEVQQ RLQNAQLALS
      781 RLYEEEEETQ RFLDGLSYDD PPTEQTIKRH PQLREMLRRD EQTRLRLINA VLSMFHTLVM
      841 RLARDESPRP TFFDAVSLLL QQLPPDSHER EDLRAANATY AQMVKKLEQI EKAGTGASEK
      901 RFQALRELVY FFRNHEYFFQ HMVGRLGVGP QVTELYERYQ HEMEEQHLER LEREWQEEAG
      961 KLTVTSVEDV QRVLARAPSH RVMHQMQQTL TTKMQDFLDK EKRKQEEQQR QLLDGYQKKV
     1021 QQDLQRVVDA VKGEMLSTIP HQPLEATLEL LLGLDQRAQP LLDKFNQDLL SALQQLSKKL
     1081 DGRINECLHG VLTGDVERRC HPHREAAMQT QASLNHLDQI LGPQLLIHET QQALQHAVHQ
     1141 AQFIEKCQQG DPTTAIMGSE FEGDFARYRS SQQKMEGQLQ ETRQQMTETS ERLDRSLRQD
     1201 PGSSSVTRVP EKPFKGQELA GRITPPPADF QRPVFKTLLD QQADAARKAL SDEADLLNQK
     1261 VQTQLRQRDE QLSTAQNLWT DLVTRHKMSG GLDVTTPDAK ALMEKPLETL RELLGKATQQ
     1321 LPYLSAERTV RWMLAFLEEA LAQITADPTH PHHGSRTHYR NLQQQAVESA VTLAHQIEQN
     1381 AACENFIAQH QEATANGAST PRVDMVQAVE AVWQRLEPGR VAGGAARHQK VQELLQRLGQ
     1441 TLGDLELQET LATEYFALLH GIQTFSYGLD FRSQLEKIRD LRTRFAELAK RRGTRLSNEG
     1501 ALPNPRKPQA TTSLGAFTRG LNALERHVQL GHQYLLNKLN GSSLVYRLED IPSVLPPTHE
     1561 TDPALIMRDR LRRLCFARHH DTFLEVVDVF GMRQIVTQAG EPIHLVTDYG NVAFKYLALR
     1621 DDGRPLAWRR RCSGGGLKNV VTTRYKAITV AVAVCQTLRT FWPQISQYDL RPYLTQHQSH
     1681 THPAETHTLH NLKLFCYLVS TAWHQRIDTQ QELTAADRVG SGEGGDVGEQ RPGRGTVLRL
     1741 SLQEFCVLIA ALYPEYIYTV LKYPVQMSLP SLTAHLHQDV IHAVVNNTHK MPPDHLPEQV
     1801 KAFCITPTQW PAMQLNKLFW ENKLVQQLCQ VGPQKSTPPL GKLWLYAMAT LVFPQDMLQC
     1861 LWLELKPQYA ETYASVSELV QTLFQIFTQQ CEMVTEGYTQ PQLPTGEPVL QMIRVRRQDT
     1921 TTTDTNTTTE PGLLDVFIQT ETALDYALGS WLFGIPVCLG VHVADLLKGQ RVLVARHLEY
     1981 TSRDRDFLRI QRSRDLNLSQ LLQDTWTETP LEHCWLQAQI RRLRDYLRFP TRLEFIPLVI
     2041 YNAQDHTVVR VLRPPSTFEQ DHSRLVLDEA FPTFPLYDQD DNTSADNVAA SGAALTPPVP
     2101 FNRVPVNIQF LRENPPPIAR VQQPPRRHRH RAAAAADDDG QIDHVQDDTS RTADSALVST
     2161 AFGGSVFQEN RLGETPLCRD ELVAVAPGAA STSFASPPIT VLTQNVLSAL EILRLVRLDL
     2221 RQLAQSVQDT IQHMRFLYLL
//