LOCUS ACS93387.1 906 aa PRT VRL 09-MAY-2013 DEFINITION Human betaherpesvirus 5 ribonucleotide reductase subunit 1 protein. ACCESSION GQ221974-50 PROTEIN_ID ACS93387.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235154) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235154) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235154) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235154) AUTHORS Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H., Wilkinson,G.W. and Tomasec,P. TITLE Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18 JOURNAL J. Gen. Virol. 86 (PT 11), 2999-3008 (2005) PUBMED 16227221 REFERENCE 5 (bases 1 to 235154) AUTHORS Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J., Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and Davison,A.J. TITLE Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens JOURNAL J. Gen. Virol. 91 (PT 3), 605-615 (2010) PUBMED 19906940 REFERENCE 6 (bases 1 to 235154) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK COMMENT On or before Aug 17, 2009 this sequence version replaced AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1, AY325311.1, DQ195526.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="3157" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="United Kingdom" /collection_date="2001" /note="sequenced at passage 3 in human fibroblasts; three genes are mutated (RL13, UL40 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL45" /note="enzymatically inactive; tegument protein" BEGIN 1 MTPADADEEQ RVSSVPVYRC RPGRIPSRGA ETETEESSAE AVADTTGGDD SELEEGPLPG 61 GDKEASAENT NVSSGVACVA GFTSGGGVVS WRPESPSPDG TPSVLSLTRD SGPAVPSRGG 121 RVSSGLSTFN PTGATRMELD SVEEEDDFGA SLCKVSPPIQ ATRMLMGKKC HCHGYWGKFR 181 FCGVQEPARE LPSDRNALWR EMDTVSRHSA GLGSFRLFQL IMRHGPCLIR HSPRCDLLLG 241 RFYFKANWAR ESRTPLCYAS ELCDESVRRF VLRHMEDLPK LAEETARFVE LAGCWGLYAA 301 ILCLDKVCRQ LHGQDESPGG VFLRIAVALT AAIENSRHSR IYRFHLDARF EGEVLESVLK 361 RCRDGQLSLS TFTMSTVGFD RVPQYDFLIS ADPFSRDASW AAMCKWMSTL SCGVSVSVNV 421 TRLNADVNSV IRCLGGYCDL IREKEVHRPV VRVFVDMWDV AAIRVINFIL KESTSELTGV 481 CYAFNVPSVL MKRYRAREQR YSLFGRPVSR RLSDLGQESA FEKEYSRCEQ SCPKVVVNTD 541 DFLKKMLLCA LKGRASVVFV HHVVKYSIMA DSVCLPPCLS PDMASCHFGE CDMPVQRLTV 601 NVARCVFARS DEQKLHLPDV VLGNTRRYFD LSVLRELVTE AVVWGNARLD ALMSASEWWV 661 ESALEKLRPL HIGVAGLHTA LMRLGFTYFA SWDLIERIFE HMYFAAVRAS VDLCKSGLPR 721 CEWFERTIYQ EGKFIFELYR LPRLSIASAR WEALRADMLE FGLRNCQFLA VGPDDEVAHL 781 WGVTPSVWAS RGTVFEEETV WSLCPPNREC YFPTVVRRPL RVPVVNYAWL EQHQEEGKAT 841 QCLFQAAPAI QNDVEMAAVN LSVFVDQCVA LVFYYDSGMT PDVLLARMLK WYHWRFKVGV 901 YKYCAS //