LOCUS ACS93335.2 743 aa PRT VRL 12-OCT-2016
DEFINITION Human betaherpesvirus 5 envelope glycoprotein H protein.
ACCESSION GU937742-71
PROTEIN_ID ACS93335.2
SOURCE Human betaherpesvirus 5 (HHV-5)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235404)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235404)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235404)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 4 (bases 1 to 235404)
AUTHORS Davison,A.J.
TITLE Human cytomegalovirus RL11 gene family: variation, recombination
and transcription
JOURNAL Unpublished
REFERENCE 5 (bases 1 to 235404)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 6 (bases 1 to 235404)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On Oct 12, 2016 this sequence version replaced GU937742.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Toledo"
/isolation_source="urine from a congenitally infected
infant"
/host="Homo sapiens"
/db_xref="taxon:10359"
/country="USA"
/collection_date="1984"
/note="passaged several times in human fibroblasts;
contains inversion of 14336 bp region (genes UL128 to
UL133); 3 genes are mutated (RL13, UL9 and UL128);
acronym: HCMV; acronym: HHV-5"
protein /gene="UL75"
/note="type 1 membrane protein; putative membrane fusogen;
complexed with envelope glycoprotein L; involved in cell
entry; involved in cell-to-cell spread"
BEGIN
1 MRPGLPPYLT VFAVYLLSHL PSQRYGADAA SEALDPHAFH LLLNTYGRPI RFLRENTTQC
61 TYNSSLRNST VVRENAISFN FFQSYNQYYV FHMPRCLFAG PLAEQFLNQV DLTETLERYQ
121 QRLNTYALVS KDLASYRSFS QQLKAQDSLG QQPTTVPPPI DLSIPHVWMP PQTTPHDWKG
181 SHTTSGLHRP HFNQTCILFD GHDLLFSTVT PCLHQGFYLM DELRYVKITL TEDFFVVTVS
241 IDDDTPMLLI FGHLPRVLFK APYQRDNFIL RQTEKHELLV LVKKAQLNRH SYLKDSDFLD
301 AALDFNYLDL SALLRNSFHR YAVDVLKSGR CQMLDRRTVE MAFAYALALF AAARQEETGT
361 EISIPRALDR QAALLQIQEF MITCLSQTPP RTTLLLYPTA VDLAKRALWT PDQITDITSL
421 VRLVYILSKQ NQQHLIPQWA LRQIADFALQ LHKTHLASFL SAFARQELYL MGSLVHSMLV
481 HTTERREIFI VETGLCSLAE LSHFTQLLAH PHHEYLSDLY TPCSSSGRRD HSLERLTRLF
541 PDATVPATVP AALSILSTMQ PSTLETFPDL FCLPLGESFS ALTVSEHVSY VVTNQYLIKG
601 ISYPVSTTVV GQSLIITQTD SQTKCELTRN MHTTHSITAA LNISLENCAF CQSALLEYDD
661 TQGVINIMYM HDSDDVLFAL DPYNEVVVSS PRTHYLMLLK NGTVLEVTDV VVDATDSRLL
721 MMSVYALSAI IGIYLLYRML KTC
//