LOCUS       AAU11326.1               462 aa    PRT              HUM 04-FEB-2005
DEFINITION  Homo sapiens 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase
            4 isoform 1 protein.
ACCESSION   AY707863-1
PROTEIN_ID  AAU11326.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Ogura,T. and
            Esumi,H.
  TITLE     Hypoxia induces transcription of
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via
            hypoxia-inducible factor-1alpha activation
  JOURNAL   FEBS Lett. (2004) In press
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Minchenko,D.O., Kurashima,Y. and
            Esumi,H.
  TITLE     Alternative splicing of human
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 in melanoma
            cells
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Minchenko,O.H., Minchenko,D.O. and Opentanova,I.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2004) Molecular Biology, Institute of
            Biochemistry, Leontovycha 9, Kyiv 01601, Ukraine
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000257319"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="DB-1"
                     /cell_type="melanoma"
     protein         /gene="PFKFB4"
                     /EC_number="2.7.1.105"
                     /EC_number="3.1.3.46"
                     /function="catalyzes the synthesis and degradation of
                     fructose-2,6-biphosphate"
                     /note="alternatively spliced; contains deletion in
                     biphosphatase domain box I; bifunctional; contains both
                     kinase and biphosphatase activities;
                     fructose-6-phosphate-2-kinase/fructose-2,6-biphosphatase;
                     PFK-2; PFK-2/F-2,6-BPase; PFKFB"
BEGIN
        1 MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT
       61 RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE
      121 EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV
      181 NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY
      241 YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW
      301 TSQMKRTIQT AEALGVPYEQ WKGVCEEMTY EEIQDNYPLE FALRDQDKYR YRYPKGESYE
      361 DLVQRLEPVI MELERQENVL VICHQAVMRC LLAYFLDKAA EQLPYLKCPL HTVLKLTPVA
      421 YGCKVESIFL NVAAVNTHRD RPQNVDISRP PEEALVTVPA HQ
//