LOCUS AAR31655.1 956 aa PRT VRL 02-JUL-2013
DEFINITION Human betaherpesvirus 5 helicase-primase helicase subunit protein.
ACCESSION AY446894-100
PROTEIN_ID AAR31655.1
SOURCE Human betaherpesvirus 5 (HHV-5; HCMV)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE The most abundantly transcribed human cytomegalovirus gene (beta
2.7) is non-essential for growth in vitro
JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
PUBMED 12917473
REFERENCE 4 (bases 1 to 235646)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 5 (bases 1 to 235646)
AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
and Davison,A.J.
TITLE High-resolution human cytomegalovirus transcriptome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
PUBMED 22109557
REFERENCE 6 (bases 1 to 235646)
AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
TITLE Direct Submission
JOURNAL Unpublished
REMARK Consensus viral genome sequence in the original urine sample
confirmed from Illumina data as being identical, except for the
mutation at 176311
REFERENCE 7 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 8 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 9 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales
College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
4XX, UK
REFERENCE 10 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 11 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On or before Aug 14, 2009 this sequence version replaced
AY156043.1, AY169797.2, AY325310.1, AY446894.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Merlin"
/isolation_source="urine from a congenitally infected
child"
/host="Homo sapiens"
/culture_collection="ATCC:VR-1590"
/db_xref="taxon:10359"
/country="United Kingdom: Cardiff"
/collection_date="1999"
/collected_by="Gavin W.G. Wilkinson"
/note="originally named strain 742; passaged 3 times in
human fibroblasts; gene UL128 is mutated; populations of
mutants in RL13 predominate, but the consensus sequence of
this gene is not mutated;
acronym: HHV-5; HCMV"
protein /gene="UL105"
/locus_tag="HHV5wtgp097"
/note="involved in DNA replication"
BEGIN
1 MSMTASSSTP RPTPKYDDAL ILNLSSAAKI ERIVDKVKSL SRERFAPEDF SFQWFRSISR
61 VERTTDNNPS AATTAAATAT VHSSVSSSAA AAASSEAGGT RVPCVDRWPF FPFRALLVTG
121 TAGAGKTSSI QVLAANLDCV ITGTTVIAAQ NLSAILNRTR SAQVKTIYRV FGFVSKHVPL
181 ADSAVSHETL ERYRVCEPHE ETTIQRLQIN DLLAYWPVIA DIVDKCLNMW ERKAASASAA
241 AAAAACEDLS ELCESNIIVI DECGLMLRYM LQVVVFFYYF YNALGDTRLY RERRVPCIIC
301 VGSPTQTEAL ESRYDHYTQN KSVRKGVDVL SALIQNEVLI NYCDIADNWV MFIHNKRCTD
361 LDFGDLLKYM EFGIPLKEEH VAYVDRFVRP PSSIRNPSYA AEMTRLFLSH VEVQAYFKRL
421 HEQIRLSERH RLFDLPVYCV VNNRAYQELC ELADPLGDSP QPVELWFRQN LARIINYSQF
481 VDHNLSSEIT KEALRPAADV VATNNPSVQA HGGGGSVIGS TGGNDETAFF QDDDTTTAPD
541 SRETLLTLRI TYIKGSSVGV NSKVRACVIG YQGTVERFVD ILQKDTFIER TPCEQAAYAY
601 SLVSGLLFSA MYYFYVSPYT TEEMLRELAR VELPDVSSLC AAAAATAAAP AWSGGENPIN
661 NHVDADSSQG GQSVPVSQRM EHGQEETHDI PCLSNHHDDS DAITDAELMD HTSLYADPFF
721 LKYVKPPSLA LLSFEETVHM YTTFRDIFLK RYQLMQRLTG GRFATLPLVT YNRRNVVFKA
781 NCQISSQTGS FVGMLSHVSP AQTYTLEGYT SDNVLSLPSD RHRIHPEVVQ RGLSRLVLRD
841 ALGFLFVLDV NVSRFVESAQ GKSLHVCTTV DYGLTSRTAM TIAKSQGLSL EKVAVDFGDH
901 PKNLKMSHIY VAMSRVTDPE HLMMNVNPLR LPYEKNTAIT PYICRALKDK RTTLIF
//