LOCUS AAR31630.1 431 aa PRT VRL 02-JUL-2013
DEFINITION Human betaherpesvirus 5 envelope protein UL78 protein.
ACCESSION AY446894-75
PROTEIN_ID AAR31630.1
SOURCE Human betaherpesvirus 5 (HHV-5; HCMV)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE The most abundantly transcribed human cytomegalovirus gene (beta
2.7) is non-essential for growth in vitro
JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
PUBMED 12917473
REFERENCE 4 (bases 1 to 235646)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 5 (bases 1 to 235646)
AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
and Davison,A.J.
TITLE High-resolution human cytomegalovirus transcriptome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
PUBMED 22109557
REFERENCE 6 (bases 1 to 235646)
AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
TITLE Direct Submission
JOURNAL Unpublished
REMARK Consensus viral genome sequence in the original urine sample
confirmed from Illumina data as being identical, except for the
mutation at 176311
REFERENCE 7 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 8 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 9 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales
College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
4XX, UK
REFERENCE 10 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 11 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On or before Aug 14, 2009 this sequence version replaced
AY156043.1, AY169797.2, AY325310.1, AY446894.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Merlin"
/isolation_source="urine from a congenitally infected
child"
/host="Homo sapiens"
/culture_collection="ATCC:VR-1590"
/db_xref="taxon:10359"
/country="United Kingdom: Cardiff"
/collection_date="1999"
/collected_by="Gavin W.G. Wilkinson"
/note="originally named strain 742; passaged 3 times in
human fibroblasts; gene UL128 is mutated; populations of
mutants in RL13 predominate, but the consensus sequence of
this gene is not mutated;
acronym: HHV-5; HCMV"
protein /gene="UL78"
/locus_tag="HHV5wtgp072"
/note="type 3 membrane protein; 7 transmembrane domains;
putative chemokine receptor; possibly involved in
intracellular signalling; GPCR family"
BEGIN
1 MSPSVEETTS VTESIMFAIV SFKHMGPFEG YSMSADRAAS DLLIGMFGSV SLVNLLTIIG
61 CLWVLRVTRP PVSVMIFTWN LVLSQFFSIL ATMLSKGIML RGALNLSLCR LVLFVDDVGL
121 YSTALFFLFL ILDRLSAISY GRDLWHHETR ENAGVALYAV AFAWVLSIVA AVPTAATGSL
181 DYRWLGCQIP IQYAAVDLTI KMWFLLGAPM IAVLANVVEL AYSDRRDHVW SYVGRVCTFY
241 VTCLMLFVPY YCFRVLRGVL QPASAAGTGF GIMDYVELAT RTLLTMRLGI LPLFIIAFFS
301 REPTKDLDDS FDYLVERCQQ SCHGHFVRRL VQALKRAMYS VELAVCYFST SVRDVAEAVK
361 KSSSRCYADA TSAAVVVTTT TSEKATLVEH AEGMASEMCP GTTIDVSAES SSVLCTDGEN
421 TVASDATVTA L
//