LOCUS AAR31620.1 907 aa PRT VRL 02-JUL-2013
DEFINITION Human betaherpesvirus 5 envelope glycoprotein B protein.
ACCESSION AY446894-62
PROTEIN_ID AAR31620.1
SOURCE Human betaherpesvirus 5 (HHV-5; HCMV)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE The most abundantly transcribed human cytomegalovirus gene (beta
2.7) is non-essential for growth in vitro
JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
PUBMED 12917473
REFERENCE 4 (bases 1 to 235646)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 5 (bases 1 to 235646)
AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
and Davison,A.J.
TITLE High-resolution human cytomegalovirus transcriptome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
PUBMED 22109557
REFERENCE 6 (bases 1 to 235646)
AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
TITLE Direct Submission
JOURNAL Unpublished
REMARK Consensus viral genome sequence in the original urine sample
confirmed from Illumina data as being identical, except for the
mutation at 176311
REFERENCE 7 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 8 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 9 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales
College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
4XX, UK
REFERENCE 10 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 11 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On or before Aug 14, 2009 this sequence version replaced
AY156043.1, AY169797.2, AY325310.1, AY446894.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Merlin"
/isolation_source="urine from a congenitally infected
child"
/host="Homo sapiens"
/culture_collection="ATCC:VR-1590"
/db_xref="taxon:10359"
/country="United Kingdom: Cardiff"
/collection_date="1999"
/collected_by="Gavin W.G. Wilkinson"
/note="originally named strain 742; passaged 3 times in
human fibroblasts; gene UL128 is mutated; populations of
mutants in RL13 predominate, but the consensus sequence of
this gene is not mutated;
acronym: HHV-5; HCMV"
protein /gene="UL55"
/locus_tag="HHV5wtgp060"
/note="type 1 membrane protein; possible membrane fusogen;
binds cell surface heparan sulphate; involved in cell
entry; involved in cell-to-cell spread"
BEGIN
1 MESRIWCLVV CVNLCIVCLG AAVSSSSTRG TSATHSHHSS HTTSAAHSRS GSVSQRVTSS
61 QTVSHGVNET IYNTTLKYGD VVGVNTTKYP YRVCSMAQGT DLIRFERNIV CTSMKPINED
121 LDEGIMVVYK RNIVAHTFKV RVYQKVLTFR RSYAYIHTTY LLGSNTEYVA PPMWEIHHIN
181 SHSQCYSSYS RVIAGTVFVA YHRDSYENKT MQLMPDDYSN THSTRYVTVK DQWHSRGSTW
241 LYRETCNLNC MVTITTARSK YPYHFFATST GDVVDISPFY NGTNRNASYF GENADKFFIF
301 PNYTIVSDFG RPNSALETHR LVAFLERADS VISWDIQDEK NVTCQLTFWE ASERTIRSEA
361 EDSYHFSSAK MTATFLSKKQ EVNMSDSALD CVRDEAINKL QQIFNTSYNQ TYEKYGNVSV
421 FETTGGLVVF WQGIKQKSLV ELERLANRSS LNLTHNRTKR STDGNNATHL SNMESVHNLV
481 YAQLQFTYDT LRGYINRALA QIAEAWCVDQ RRTLEVFKEL SKINPSAILS AIYNKPIAAR
541 FMGDVLGLAS CVTINQTSVK VLRDMNVKES PGRCYSRPVV IFNFANSSYV QYGQLGEDNE
601 ILLGNHRTEE CQLPSLKIFI AGNSAYEYVD YLFKRMIDLS SISTVDSMIA LDIDPLENTD
661 FRVLELYSQK ELRSSNVFDL EEIMREFNSY KQRVKYVEDK VVDPLPPYLK GLDDLMSGLG
721 AAGKAVGVAI GAVGGAVASV VEGVATFLKN PFGAFTIILV AIAVVIITYL IYTRQRRLCT
781 QPLQNLFPYL VSADGTTVTS GSTKDTSLQA PPSYEESVYN SGRKGPGPPS SDASTAAPPY
841 TNEQAYQMLL ALARLDAEQR AQQNGTDSLD GRTGTQDKGQ KPNLLDRLRH RKNGYRHLKD
901 SDEEENV
//