LOCUS AAR31614.1 570 aa PRT VRL 02-JUL-2013
DEFINITION Human betaherpesvirus 5 protein UL49 protein.
ACCESSION AY446894-56
PROTEIN_ID AAR31614.1
SOURCE Human betaherpesvirus 5 (HHV-5; HCMV)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE The most abundantly transcribed human cytomegalovirus gene (beta
2.7) is non-essential for growth in vitro
JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
PUBMED 12917473
REFERENCE 4 (bases 1 to 235646)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 5 (bases 1 to 235646)
AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
and Davison,A.J.
TITLE High-resolution human cytomegalovirus transcriptome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
PUBMED 22109557
REFERENCE 6 (bases 1 to 235646)
AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
TITLE Direct Submission
JOURNAL Unpublished
REMARK Consensus viral genome sequence in the original urine sample
confirmed from Illumina data as being identical, except for the
mutation at 176311
REFERENCE 7 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 8 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 9 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales
College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
4XX, UK
REFERENCE 10 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 11 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On or before Aug 14, 2009 this sequence version replaced
AY156043.1, AY169797.2, AY325310.1, AY446894.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Merlin"
/isolation_source="urine from a congenitally infected
child"
/host="Homo sapiens"
/culture_collection="ATCC:VR-1590"
/db_xref="taxon:10359"
/country="United Kingdom: Cardiff"
/collection_date="1999"
/collected_by="Gavin W.G. Wilkinson"
/note="originally named strain 742; passaged 3 times in
human fibroblasts; gene UL128 is mutated; populations of
mutants in RL13 predominate, but the consensus sequence of
this gene is not mutated;
acronym: HHV-5; HCMV"
protein /gene="UL49"
/locus_tag="HHV5wtgp054"
BEGIN
1 MANRRLRHAP HTATDEFHQA LRRLFAPLCV HEDHFHVQLV IGRGALQPEE AAVETSQPPA
61 QFAAQTSAVL QQQLVHHVPR SCVLHLFVTD KRFLNRELGD RLYQRFLREW LVCRQAEREA
121 VTALFQRMVM TKPYFVFLAY VYSMDCLHTV AVRTMAFLRF ERYDTDYLLR RLRLYPPERL
181 HALLDGVTVS LLGDLHRFLF GVDLRLPVLH PTSSPCLALL RAKRFDARAD LAVYHRNQWC
241 HQRQPRSPQL RGLIAALRRH AGKVPCGNPL YVLARQAVQT FCDTCPRYLV PLRALGLHDE
301 TRGGGSTAAA AAVGHAGAGQ QAHHVEPTKI VLFALSAALR GGLIGSVIDL PLWCLCRLKC
361 ERHLDARSLV AVVCRQCGHC LNLGKEKLHC QQNFPLNSMF YYRDRQEKSV IFNTHAELVH
421 CSLCGSQRVV RQRVYELVSE TLFGQRCVRV GWKAVLGLNA ACAVYDHRLA FDVILPCAAR
481 TCDSTVVVRG VTVPRLLRLT SHGHGLLCAR CQTGEYRDSC LESEDGAPLC RGCALVKQTA
541 CHVGGHIVQQ ARGGLAATSS SSSPHGLPHV
//