LOCUS AAR31613.1 2241 aa PRT VRL 02-JUL-2013
DEFINITION Human betaherpesvirus 5 large tegument protein protein.
ACCESSION AY446894-54
PROTEIN_ID AAR31613.1
SOURCE Human betaherpesvirus 5 (HHV-5; HCMV)
ORGANISM Human betaherpesvirus 5
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
Herviviricetes; Herpesvirales; Orthoherpesviridae;
Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE 1 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Homology between the human cytomegalovirus RL11 gene family and
human adenovirus E3 genes
JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003)
PUBMED 12604818
REFERENCE 2 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Two novel spliced genes in human cytomegalovirus
JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
PUBMED 12692276
REFERENCE 3 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE The most abundantly transcribed human cytomegalovirus gene (beta
2.7) is non-essential for growth in vitro
JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
PUBMED 12917473
REFERENCE 4 (bases 1 to 235646)
AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
Davison,A.J.
TITLE Genetic content of wild-type human cytomegalovirus
JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
PUBMED 15105547
REFERENCE 5 (bases 1 to 235646)
AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
and Davison,A.J.
TITLE High-resolution human cytomegalovirus transcriptome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
PUBMED 22109557
REFERENCE 6 (bases 1 to 235646)
AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
TITLE Direct Submission
JOURNAL Unpublished
REMARK Consensus viral genome sequence in the original urine sample
confirmed from Illumina data as being identical, except for the
mutation at 176311
REFERENCE 7 (bases 1 to 235646)
AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 8 (bases 1 to 235646)
AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
Wilkinson,G.W. and Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 9 (bases 1 to 235646)
AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales
College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
4XX, UK
REFERENCE 10 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REFERENCE 11 (bases 1 to 235646)
AUTHORS Davison,A.J.
TITLE Direct Submission
JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
G11 5JR, UK
REMARK Sequence update by submitter
COMMENT On or before Aug 14, 2009 this sequence version replaced
AY156043.1, AY169797.2, AY325310.1, AY446894.1.
The original gene nomenclature has been retained. Genes presumably
inherited from the common ancestor of alpha-, beta- and
gammaherpesviruses (core genes), from the common ancestor of beta-
and gammaherpesviruses (betagamma genes), or from the common
ancestor of betaherpesviruses (beta genes) are indicated. A
standard protein nomenclature has been applied so that orthologs
have the same name in all herpesviruses.
FEATURES Qualifiers
source /organism="Human betaherpesvirus 5"
/mol_type="genomic DNA"
/strain="Merlin"
/isolation_source="urine from a congenitally infected
child"
/host="Homo sapiens"
/culture_collection="ATCC:VR-1590"
/db_xref="taxon:10359"
/country="United Kingdom: Cardiff"
/collection_date="1999"
/collected_by="Gavin W.G. Wilkinson"
/note="originally named strain 742; passaged 3 times in
human fibroblasts; gene UL128 is mutated; populations of
mutants in RL13 predominate, but the consensus sequence of
this gene is not mutated;
acronym: HHV-5; HCMV"
protein /gene="UL48"
/locus_tag="HHV5wtgp052"
/note="complexed with tegument protein UL37;
ubiquitin-specific protease (N-terminal region); involved
in capsid transport"
BEGIN
1 MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD AIMEEGARLD
61 ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA LSRPFNGTTE TCDLDGYMCP
121 GIFDFLRYAH AKPRPTYVLV TVNSLARAVV FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ
181 VLMVLTGFGV QLSPAFYYEA LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESAD
241 TAATTTTAAP SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK
301 KKPPSTTSKT LATASSSPSA IAAASSSSAV PPSYSCGEGA LPALGRYQQL VDEVEQELKA
361 LTLPPLPANT SAWTLHAAGT ESGANAATAT APSFDEAFLT DRLQQLIIHA VNQRSCLRRP
421 CGPQSAAQQA VRAYLGLSKK LDAFLLNWLH HGLDLQRMHD YLSHKTTKGT YSTLDRALLE
481 KMQVVFDPYG RQHGPALIAW VEEMLRYVES KPTNELSQRL QRFVTKRPMP VSDSFVCLRP
541 VDFQRLTQVI EQRRRVLQRQ REEYHGVYEH LAGLITSIDI HDLDASDLNR REILKALQPL
601 DDNAKQELFR LGNAKMLELQ MDLDRLSTQL LTRVHNHILN GFLPVEDLKQ MERVVEQVLR
661 LFYDLRDLKL CDGSYEEGFV VIREQLSYLM TGTVRDNVPL LQEILQLRHA YQQATQQNEG
721 RLTQIHDLLH VIETLVRDPG SRGSALTLAL VQEQLAQLEA LGGLQLPEVQ QRLQNAQLAL
781 SRLYEEEEET QRFLDGLSYD DPPTEQTIKR HPQLREMLRR DEQTRLRLIN AVLSMFHTLV
841 MRLARDESPR PTFFDAVSLL LQQLPPDSHE REDLRAANAT YAQMVKKLEQ IEKAGTGASE
901 KRFQALRELV YFFRNHEYFF QHMVGRLGVG PQVTELYERY QHEMEEQHLE RLEREWQEEA
961 GKLTVTSVED VQRVLARAPS HRVMHQMQQT LTTKMQDFLD KEKRKQEEQQ RQLLDGYQKK
1021 VQQDLQRVVD AVKGEMLSTI PHQPLEATLE LLLGLDQRAQ PLLDKFNQDL LSALQQLSKK
1081 LDGRINECLH GVLTGDVERR CHPHREAAMQ TQASLNHLDQ ILGPQLLIHE TQQALQHAVH
1141 QAQFIEKCQQ GDPTTAITGS EFESDFARYR SSQQKMEGQL QETRQQMTET SERLDRSLRQ
1201 DPGSSSVTRV PEKPFKGQEL AGRITPPPAD FQRPVFKTLL DQQADAARKA LSDEADLLNQ
1261 KVQTQLRQRD EQLSTAQNLW TDLVTRHKMS GGLDVTTPDA KALMEKPLET LRELLGKATQ
1321 QLPYLSAERT VRWMLAFLEE ALAQITADPT HPHHGSRTHY RNLQQQAVES AVTLAHQIEQ
1381 NAACENFIAQ HQEATANGAS TPRVDMVQAV EAVWQRLEPG RVAGGAARHQ KVQELLQRLG
1441 QTLGDLELQE TLATEYFALL HGIQTFSYGL DFRSQLEKIR DLRTRFAELA KRCGTRLSNE
1501 GALPNPRKPQ ATTSLGAFTR GLNALERHVQ LGHQYLLNKL NGSSLVYRLE DIPSVLPPTH
1561 ETDPALIMRD RLRRLCFARH HDTFLEVVDV FGMRQIVTQA GEPIYLVTDY GNVAFKYLAL
1621 RDDGRPLAWR RRCSGGGLKN VVTTRYKAIT VAVAVCQTLR TFWPQISQYD LRPYLTQHQS
1681 HTHPAETHTL HNLKLFCYLV STAWHQRIDT QQELTAADRV GSGEGGDVGE QRPGRGTVLR
1741 LSLQEFCVLI AALYPEYIYT VLKYPVQMSL PSLTAHLHQD VIHAVVNNTH KMPPDHLPEQ
1801 VKAFCITPTQ WPAMQLNKLF WENKLVQQLC QVGPQKSTPS LGKLWLYAMA TLVFPQDMLQ
1861 CLWLELKPQY AETYASVSEL VQTLFQIFTQ QCEMVTEGYT QPQLPTGEPV LQMIRVRRQD
1921 TTTTDTNTTT EPGLLDVFIQ TETALDYALG SWLFGIPVCL GVHVADLLKG QRVLVARHLE
1981 YTSRDRDFLR IQRSRDLNLS QLLQDTWTET PLEHCWLQAQ IRRLRDYLRF PTRLEFIPLV
2041 IYNAQDHTVV RVLRPPSTFE QDHSRLVLDE AFPTFPLYDQ DDNTSADNVA ASGAAPTPPV
2101 PFNRVPVNIQ FLRENPPPIA RVQQPPRRHR HRAAAAADDD GQIDHAQDDT SRTADSALVS
2161 TAFGGSVFQE NRLGETPLCR DELVAVAPGA ASTSFASPPI TVLTQNVLSA LEILRLVRLD
2221 LRQLAQSVQD TIQHMRFLYL L
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