LOCUS AAR31611.1 983 aa PRT VRL 02-JUL-2013 DEFINITION Human betaherpesvirus 5 tegument protein UL37 protein. ACCESSION AY446894-53 PROTEIN_ID AAR31611.1 SOURCE Human betaherpesvirus 5 (HHV-5; HCMV) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003) PUBMED 12917473 REFERENCE 4 (bases 1 to 235646) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 5 (bases 1 to 235646) AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J., Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W. and Davison,A.J. TITLE High-resolution human cytomegalovirus transcriptome JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011) PUBMED 22109557 REFERENCE 6 (bases 1 to 235646) AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G. TITLE Direct Submission JOURNAL Unpublished REMARK Consensus viral genome sequence in the original urine sample confirmed from Illumina data as being identical, except for the mutation at 176311 REFERENCE 7 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 8 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Direct Submission JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 9 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF14 4XX, UK REFERENCE 10 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 11 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On or before Aug 14, 2009 this sequence version replaced AY156043.1, AY169797.2, AY325310.1, AY446894.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Merlin" /isolation_source="urine from a congenitally infected child" /host="Homo sapiens" /culture_collection="ATCC:VR-1590" /db_xref="taxon:10359" /country="United Kingdom: Cardiff" /collection_date="1999" /collected_by="Gavin W.G. Wilkinson" /note="originally named strain 742; passaged 3 times in human fibroblasts; gene UL128 is mutated; populations of mutants in RL13 predominate, but the consensus sequence of this gene is not mutated; acronym: HHV-5; HCMV" protein /gene="UL47" /locus_tag="HHV5wtgp051" /note="complexed with large tegument protein; involved in virion morphogenesis" BEGIN 1 MMARRTVDFK KLIEQLRARA TDKAEALNTV SQLEIGAVDA QDVTASAVRA FVGALPSSGY 61 HFGFVRQNVV FYLLSHATVQ TARDPLYAAE QLHEQLDRFL RHQHDGGGDE DRLPFYHNGA 121 TLTAFQKLLQ TLREIQTVIA EQSGGTAAAA DLIASNNAST ERRGKKGGSS SGGQQPLVRR 181 VITQLETAAT EARPYVNCRA VAELLDLTYQ RLIYWACTLM PYVLFRRDTD TELDTVLLMH 241 FFYTHYRSVN GDLAVEFQNY VKNSVRHMSS FVSSDIDGDQ KPGAEHMRDV SYKLFVGNLQ 301 ARDASGLMFP IISTRISTVN LYLSPERMFF HPGLISRLLS EEVSPRANLD AYARVCDRVL 361 EDHLHTPRRV QRLLDLTQMV MRLVELGFNH DTCAAYAQMA LIQPASQKSS LFVSEIREKL 421 IQIIYNFYTF FMCLYVYSPT FLFDHRRRLI LEQHRSTLIG SKEELQHVWS NVTLNVNTHF 481 AVQYTEEDFE AHTKGATEAE REYLYRDLHS KWGVHLFTLR PSRGAAGAAS PLPPLDGVTR 541 SDILRECALV NLNEGRVNYA SLLAFSHHPE FPSIFAQLVV VTEFSEIFGI PQGLFQAVGS 601 PRLFALIQLC RVLLPEQVTL YQNLVSIYNL TTFVKHIDAA VFKTVRDCVF DIATTLEHLS 661 GVPVTPNVDL LAELMARSVA HNLYTTVNPL IEDVMRSSAG SLRNYLRHTR LCFGLARGRA 721 RLSEDGVTVY VEVQGQYGLR VPTTRFVEQL RELVRRDRLL AENLRGLNER LLSVRVRVRQ 781 ISSDTEEVSR HAKGHRTVAQ MSKALKKTAS KIKMLETRVT LALEQAQRSN GAVVTAVQRA 841 LAVFDVLSRE NLERRGAQLC LTEATSLLHR HRALAPMTWP AGTGVAAAAE ADGALREFLE 901 APWESAPQPP RLRMTPDTDH EESTAGATSV PEVLGARYEP AHLAASDLLN WYIVPVSQAQ 961 QDILSSIDPP AGSTSVSLPP ASP //