LOCUS AAR31609.1 906 aa PRT VRL 02-JUL-2013 DEFINITION Human betaherpesvirus 5 ribonucleotide reductase subunit 1 protein. ACCESSION AY446894-51 PROTEIN_ID AAR31609.1 SOURCE Human betaherpesvirus 5 (HHV-5; HCMV) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003) PUBMED 12917473 REFERENCE 4 (bases 1 to 235646) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 5 (bases 1 to 235646) AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J., Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W. and Davison,A.J. TITLE High-resolution human cytomegalovirus transcriptome JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011) PUBMED 22109557 REFERENCE 6 (bases 1 to 235646) AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G. TITLE Direct Submission JOURNAL Unpublished REMARK Consensus viral genome sequence in the original urine sample confirmed from Illumina data as being identical, except for the mutation at 176311 REFERENCE 7 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 8 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Direct Submission JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 9 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF14 4XX, UK REFERENCE 10 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 11 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On or before Aug 14, 2009 this sequence version replaced AY156043.1, AY169797.2, AY325310.1, AY446894.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Merlin" /isolation_source="urine from a congenitally infected child" /host="Homo sapiens" /culture_collection="ATCC:VR-1590" /db_xref="taxon:10359" /country="United Kingdom: Cardiff" /collection_date="1999" /collected_by="Gavin W.G. Wilkinson" /note="originally named strain 742; passaged 3 times in human fibroblasts; gene UL128 is mutated; populations of mutants in RL13 predominate, but the consensus sequence of this gene is not mutated; acronym: HHV-5; HCMV" protein /gene="UL45" /locus_tag="HHV5wtgp049" /note="enzymatically inactive; tegument protein" BEGIN 1 MNPADADEEQ RVSSVPAHRC RPGRIPSRSA ETETEESSAE VAADTIGGDD SELEEGPLPG 61 GDKEASAGNT NVSSGVACVA GFTSGGGVVS WRPESPSPDG TPSVLSLTRD SGPAVPSRGG 121 RVSSGLSTFN PAGATRMELD SVEEEDDFGA SLCKVSPPIQ AMRMLMGKKC HCHGYWGKFR 181 FCGVQEPARE LPSDRNALWR EMDTVSRHSA GLGSFRLFQL IMRHGPCLIR HSPRCDLLLG 241 RFYFKANWAR ESRTPLCYAS ELCDESVRRF VLRHMEDLPK LAEETARFVE LAGCWGLYAA 301 ILCLDKVCRQ LHGQDESPGG VFLRIAVALT AAIENSRHSR IYRFHLDARF EGEVLESVLK 361 RCRDGQLSLS TFTMSTVGFD RVPQYDFLIS ADPFSRDASW AAMCKWMSTL SCGVSVSVNV 421 TRLNADVNSV IRCLGGYCDL IREKEVHRPV VRVFVDMWDV AAIRVINFIL KESTSELTGV 481 CYAFNVPSVL MKRYRAREQR YSLFGRPVSR RLSDLGQESA FEKEYSRCEQ SCPKVVVNTD 541 DFLKKMLLCA LKGRASVVFV HHVVKYSIMA DSVCLPPCLS PDMASCHFGE CDMPVQRLTV 601 NVARCVFARS DEQKLHLPDV VLGNTRRYFD LSVLRELVTE AVVWGNARLD ALMSASEWWV 661 ESALEKLRPL HIGVAGLHTA LMRLGFTYFA SWDLIERIFE HMYFAAVRAS VDLCKSGLPR 721 CEWFERTIYQ EGKFIFELYR LPRLSIASAR WEALRADMLE FGLRNCQFLA VGPDDEVAHL 781 WGVTPSVWAS RGTVFEEETV WSLCPPNREC YFPTVVRRPL RVPVVNYAWL EQHQEEGKAT 841 QCLFQAAPAI QNDVEMAAVN LSVFVDQCVA LVFYYDSGMT PDVLLARMLK WYHWRFKVGV 901 YKYCAS //