LOCUS       AAR31505.1               580 aa    PRT              VRL 12-OCT-2016
DEFINITION  Human betaherpesvirus 5 regulatory protein IE2 protein.
ACCESSION   GU937742-109
PROTEIN_ID  AAR31505.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
            Herviviricetes; Herpesvirales; Orthoherpesviridae;
            Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE   1  (bases 1 to 235404)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235404)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235404)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Human cytomegalovirus RL11 gene family: variation, recombination
            and transcription
  JOURNAL   Unpublished
REFERENCE   5  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   6  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
  REMARK    Sequence update by submitter
COMMENT     On Oct 12, 2016 this sequence version replaced GU937742.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="Toledo"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="USA"
                     /collection_date="1984"
                     /note="passaged several times in human fibroblasts;
                     contains inversion of 14336 bp region (genes UL128 to
                     UL133); 3 genes are mutated (RL13, UL9 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="UL122"
                     /note="interacts with basal transcriptional machinery and
                     cellular transcription factors; specific DNA-binding
                     protein; involved in gene regulation"
     intron_pos      24:2 (1/2)
     intron_pos      86:1 (2/2)
BEGIN
        1 MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL GDPLFPELAE
       61 ESLKTFEQVT EDCNENPEKD VLAELGDILA QAVNHAGIDS SSTGPTLTTH SCSVSSAPLN
      121 KPTPTSVAVT NTPLPGASAT PELSPRKKPR KTTRPFKVII KPPVPPAPIM LPLIKQEDIK
      181 PEPDFTIQYR NKIIDTAGCI VISDSEEEQG EEVETRGATA SSPSTGSGTP RVTSPTHPLS
      241 QMNHPPLPDP LARPDEDSSS SSSSSCSSAS DSESESEEMK CSSGGGASVT SSHHGRGGFG
      301 GAASSSLLSC GHQSSGGAST GPRKKKSKRI SELDNEKVRN IMKDKNTPFC TPNVQTRRGR
      361 VKIDEVSRMF RNTNRSLEYK NLPFTIPSMH QVLDEAIKAC KTMQVNNKGI QIIYTRNHEV
      421 KSEVDAVRCR LGTMCNLALS TPFLMEHTMP VTHPPEVAQR TADACNEGVK AAWSLKELHT
      481 HQLCPRSSDY RNMIIHAATP VDLLGALNLC LPLMQKFPKQ VMVRIFSTNQ GGFMLPIYET
      541 AAKAYAVGQF EQPTETPPED LDTLSLAIEA AIQDLRNKSQ
//