LOCUS       AAG08358.1               627 aa    PRT              BCT 31-JAN-2014
DEFINITION  Pseudomonas aeruginosa PAO1 thiamin biosynthesis protein
            ThiC protein.
ACCESSION   AE004091-4973
PROTEIN_ID  AAG08358.1
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (bases 1 to 6264404)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   2  (bases 1 to 6264404)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic Acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   3  (bases 1 to 6264404)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic Acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   4  (bases 1 to 6264404)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
REFERENCE   5  (bases 1 to 6264404)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   6  (bases 1 to 6264404)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 6264404)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 6264404)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Protein update by submitter
COMMENT     On or before Jul 7, 2006 this sequence version replaced AE004440.1,
            AE004441.1, AE004442.1, AE004443.1, AE004444.1, AE004445.1,
            AE004446.1, AE004447.1, AE004448.1, AE004449.1, AE004450.1,
            AE004451.1, AE004452.1, AE004453.1, AE004454.1, AE004455.1,
            AE004456.1, AE004457.1, AE004458.1, AE004459.1, AE004460.1,
            AE004461.1, AE004462.1, AE004463.1, AE004464.1, AE004465.1,
            AE004466.1, AE004467.1, AE004468.1, AE004469.1, AE004470.1,
            AE004471.1, AE004472.1, AE004473.1, AE004474.1, AE004475.1,
            AE004476.1, AE004477.1, AE004478.1, AE004479.1, AE004480.1,
            AE004481.1, AE004482.1, AE004483.1, AE004484.1, AE004485.1,
            AE004486.1, AE004487.1, AE004488.1, AE004489.1, AE004490.1,
            AE004491.1, AE004492.1, AE004493.1, AE004494.1, AE004495.1,
            AE004496.1, AE004497.1, AE004498.1, AE004499.1, AE004500.1,
            AE004501.1, AE004502.1, AE004503.1, AE004504.1, AE004505.1,
            AE004506.1, AE004507.1, AE004508.1, AE004509.1, AE004510.1,
            AE004511.1, AE004512.1, AE004513.1, AE004514.1, AE004515.1,
            AE004516.1, AE004517.1, AE004518.1, AE004519.1, AE004520.1,
            AE004521.1, AE004522.1, AE004523.1, AE004524.1, AE004525.1,
            AE004526.1, AE004527.1, AE004528.1, AE004529.1, AE004530.1,
            AE004531.1, AE004532.1, AE004533.1, AE004534.1, AE004535.1,
            AE004536.1, AE004537.1, AE004538.1, AE004539.1, AE004540.1,
            AE004541.1, AE004542.1, AE004543.1, AE004544.1, AE004545.1,
            AE004546.1, AE004547.1, AE004548.1, AE004549.1, AE004550.1,
            AE004551.1, AE004552.1, AE004553.1, AE004554.1, AE004555.1,
            AE004556.1, AE004557.1, AE004558.1, AE004559.1, AE004560.1,
            AE004561.1, AE004562.1, AE004563.1, AE004564.1, AE004565.1,
            AE004566.1, AE004567.1, AE004568.1, AE004569.1, AE004570.1,
            AE004571.1, AE004572.1, AE004573.1, AE004574.1, AE004575.1,
            AE004576.1, AE004577.1, AE004578.1, AE004579.1, AE004580.1,
            AE004581.1, AE004582.1, AE004583.1, AE004584.1, AE004585.1,
            AE004586.1, AE004587.1, AE004588.1, AE004589.1, AE004590.1,
            AE004591.1, AE004592.1, AE004593.1, AE004594.1, AE004595.1,
            AE004596.1, AE004597.1, AE004598.1, AE004599.1, AE004600.1,
            AE004601.1, AE004602.1, AE004603.1, AE004604.1, AE004605.1,
            AE004606.1, AE004607.1, AE004608.1, AE004609.1, AE004610.1,
            AE004611.1, AE004612.1, AE004613.1, AE004614.1, AE004615.1,
            AE004616.1, AE004617.1, AE004618.1, AE004619.1, AE004620.1,
            AE004621.1, AE004622.1, AE004623.1, AE004624.1, AE004625.1,
            AE004626.1, AE004627.1, AE004628.1, AE004629.1, AE004630.1,
            AE004631.1, AE004632.1, AE004633.1, AE004634.1, AE004635.1,
            AE004636.1, AE004637.1, AE004638.1, AE004639.1, AE004640.1,
            AE004641.1, AE004642.1, AE004643.1, AE004644.1, AE004645.1,
            AE004646.1, AE004647.1, AE004648.1, AE004649.1, AE004650.1,
            AE004651.1, AE004652.1, AE004653.1, AE004654.1, AE004655.1,
            AE004656.1, AE004657.1, AE004658.1, AE004659.1, AE004660.1,
            AE004661.1, AE004662.1, AE004663.1, AE004664.1, AE004665.1,
            AE004666.1, AE004667.1, AE004668.1, AE004669.1, AE004670.1,
            AE004671.1, AE004672.1, AE004673.1, AE004674.1, AE004675.1,
            AE004676.1, AE004677.1, AE004678.1, AE004679.1, AE004680.1,
            AE004681.1, AE004682.1, AE004683.1, AE004684.1, AE004685.1,
            AE004686.1, AE004687.1, AE004688.1, AE004689.1, AE004690.1,
            AE004691.1, AE004692.1, AE004693.1, AE004694.1, AE004695.1,
            AE004696.1, AE004697.1, AE004698.1, AE004699.1, AE004700.1,
            AE004701.1, AE004702.1, AE004703.1, AE004704.1, AE004705.1,
            AE004706.1, AE004707.1, AE004708.1, AE004709.1, AE004710.1,
            AE004711.1, AE004712.1, AE004713.1, AE004714.1, AE004715.1,
            AE004716.1, AE004717.1, AE004718.1, AE004719.1, AE004720.1,
            AE004721.1, AE004722.1, AE004723.1, AE004724.1, AE004725.1,
            AE004726.1, AE004727.1, AE004728.1, AE004729.1, AE004730.1,
            AE004731.1, AE004732.1, AE004733.1, AE004734.1, AE004735.1,
            AE004736.1, AE004737.1, AE004738.1, AE004739.1, AE004740.1,
            AE004741.1, AE004742.1, AE004743.1, AE004744.1, AE004745.1,
            AE004746.1, AE004747.1, AE004748.1, AE004749.1, AE004750.1,
            AE004751.1, AE004752.1, AE004753.1, AE004754.1, AE004755.1,
            AE004756.1, AE004757.1, AE004758.1, AE004759.1, AE004760.1,
            AE004761.1, AE004762.1, AE004763.1, AE004764.1, AE004765.1,
            AE004766.1, AE004767.1, AE004768.1, AE004769.1, AE004770.1,
            AE004771.1, AE004772.1, AE004773.1, AE004774.1, AE004775.1,
            AE004776.1, AE004777.1, AE004778.1, AE004779.1, AE004780.1,
            AE004781.1, AE004782.1, AE004783.1, AE004784.1, AE004785.1,
            AE004786.1, AE004787.1, AE004788.1, AE004789.1, AE004790.1,
            AE004791.1, AE004792.1, AE004793.1, AE004794.1, AE004795.1,
            AE004796.1, AE004797.1, AE004798.1, AE004799.1, AE004800.1,
            AE004801.1, AE004802.1, AE004803.1, AE004804.1, AE004805.1,
            AE004806.1, AE004807.1, AE004808.1, AE004809.1, AE004810.1,
            AE004811.1, AE004812.1, AE004813.1, AE004814.1, AE004815.1,
            AE004816.1, AE004817.1, AE004818.1, AE004819.1, AE004820.1,
            AE004821.1, AE004822.1, AE004823.1, AE004824.1, AE004825.1,
            AE004826.1, AE004827.1, AE004828.1, AE004829.1, AE004830.1,
            AE004831.1, AE004832.1, AE004833.1, AE004834.1, AE004835.1,
            AE004836.1, AE004837.1, AE004838.1, AE004839.1, AE004840.1,
            AE004841.1, AE004842.1, AE004843.1, AE004844.1, AE004845.1,
            AE004846.1, AE004847.1, AE004848.1, AE004849.1, AE004850.1,
            AE004851.1, AE004852.1, AE004853.1, AE004854.1, AE004855.1,
            AE004856.1, AE004857.1, AE004858.1, AE004859.1, AE004860.1,
            AE004861.1, AE004862.1, AE004863.1, AE004864.1, AE004865.1,
            AE004866.1, AE004867.1, AE004868.1, AE004869.1, AE004870.1,
            AE004871.1, AE004872.1, AE004873.1, AE004874.1, AE004875.1,
            AE004876.1, AE004877.1, AE004878.1, AE004879.1, AE004880.1,
            AE004881.1, AE004882.1, AE004883.1, AE004884.1, AE004885.1,
            AE004886.1, AE004887.1, AE004888.1, AE004889.1, AE004890.1,
            AE004891.1, AE004892.1, AE004893.1, AE004894.1, AE004895.1,
            AE004896.1, AE004897.1, AE004898.1, AE004899.1, AE004900.1,
            AE004901.1, AE004902.1, AE004903.1, AE004904.1, AE004905.1,
            AE004906.1, AE004907.1, AE004908.1, AE004909.1, AE004910.1,
            AE004911.1, AE004912.1, AE004913.1, AE004914.1, AE004915.1,
            AE004916.1, AE004917.1, AE004918.1, AE004919.1, AE004920.1,
            AE004921.1, AE004922.1, AE004923.1, AE004924.1, AE004925.1,
            AE004926.1, AE004927.1, AE004928.1, AE004929.1, AE004930.1,
            AE004931.1, AE004932.1, AE004933.1, AE004934.1, AE004935.1,
            AE004936.1, AE004937.1, AE004938.1, AE004939.1, AE004940.1,
            AE004941.1, AE004942.1, AE004943.1, AE004944.1, AE004945.1,
            AE004946.1, AE004947.1, AE004948.1, AE004949.1, AE004950.1,
            AE004951.1, AE004952.1, AE004953.1, AE004954.1, AE004955.1,
            AE004956.1, AE004957.1, AE004958.1, AE004959.1, AE004960.1,
            AE004961.1, AE004962.1, AE004963.1, AE004964.1, AE004965.1,
            AE004966.1, AE004967.1, AE004968.1, AE004091.1.
            -----------------------------------------------------------------
            This represents the Sept 08, 2010 version of the continually
            updated, reviewed, Pseudomonas aeruginosa PAO1 genome annotation
            from PseudoCap (see http://www.pseudomonas.com for the latest
            updates and links to alternate annotations). This update includes
            updated base pair coordinates and new features. PseudoCap is
            coordinated by Fiona S.L. Brinkman (Simon Fraser University,
            Canada) and Robert E.W. Hancock (University of British Columbia,
            Canada) with database development by Geoff Winsor (Simon Fraser
            University). We welcome submission through
            www.pseudomonas.com of any proposed changes.
            'Protein name confidence' is used to rate our confidence of the
            accuracy of the protein name.
            Class 1: Function experimentally demonstrated in P. aeruginosa.
            Class 2: Function of highly similar gene experimentally
            demonstrated in another organism (and gene context consistent in
            terms of pathways its involved in, if known).
            Class 3: Function proposed based on presence of conserved amino
            acid motif, structural feature or limited sequence similarity to an
            experimentally studied gene.
            Class 4: Homologs of previously reported genes of unknown function,
            or no similarity to any previously reported sequences.
            ------------------------------------------------------------------.
FEATURES             Qualifiers
     source          /organism="Pseudomonas aeruginosa PAO1"
                     /mol_type="genomic DNA"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     protein         /gene="thiC"
                     /locus_tag="PA4973"
                     /note="Product name confidence: Class 2 (High similarity
                     to functionally studied protein)"
                     /transl_table=11
BEGIN
        1 MSATQKNNIT RLEQLDRQST QPFPNSRKVY LTGSRPDIRV PVREISLADT PTAFGGEKNP
       61 PVFVYDTSGP YTDPEVRIDL RKGLPDVRSR WIDERGDTEI LPGLTSEFGQ ARLADASLDA
      121 LRFAHVRTPR RAKPGANVSQ MHYAKKGIIT PEMEYIAIRE NMKLQEARAA GLLDQQHPGH
      181 SFGANIPKEI TPEFVREEVA RGRAIIPANI NHTELEPMII GRNFLVKING NIGNSALGSS
      241 IEEEVEKLTW GIRWGADTVM DLSTGKHIHE TREWILRNSP VPIGTVPIYQ ALEKVNGVAE
      301 DLTWEIFRDT LIEQAEQGVD YFTIHAGVLL RYVPLTAKRV TGIVSRGGSI MAKWCLAHHQ
      361 ENFLYTHFEE ICEIMKAYDV SFSLGDGLRP GSVADANDAA QFGELETLGE LTKIAWKHDV
      421 QVMIEGPGHV PMQLIKENMD KQLECCDEAP FYTLGPLTTD IAPGYDHITS GIGAAMIGWF
      481 GCAMLCYVTP KEHLGLPNKD DVKTGIITYK IAAHAADLAK GHPGAQIRDN ALSKARFEFR
      541 WEDQFNLGLD PDTARAFHDE TLPKDSAKVA HFCSMCGPKF CSMKITQEVR DYAKENGLSD
      601 ESKAIEAGFQ EQAARFKDEG SVIYRQV
//