LOCUS       AAF36817.1              1544 aa    PRT              HUM 02-MAR-2000
DEFINITION  Homo sapiens guanine nucleotide exchange factor protein.
ACCESSION   AF180681-1
PROTEIN_ID  AAF36817.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9501)
  AUTHORS   Kourlas,P.J., Strout,M.P., Becknell,B., Veronese,M.L., Croce,C.M.,
            Theil,K.S., Krahe,R., Ruutu,T., Knuutila,S., Bloomfield,C.D. and
            Caligiuri,M.A.
  TITLE     Identification of a gene at 11q23 encoding a guanine nucleotide
            exchange factor: evidence for its fusion with MLL in acute myeloid
            leukemia
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (5), 2145-2150 (2000)
   PUBMED   10681437
REFERENCE   2  (bases 1 to 9501)
  AUTHORS   Kourlas,P.J., Strout,M.P., Becknell,B., Bloomfield,C.B. and
            Caligiuri,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-AUG-1999) Internal Medicine, Division of
            Hematology-Oncology, The Ohio State University, 4th floor
            Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000072800"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
                     /tissue_type="prostate"
     protein         /gene="LARG"
BEGIN
        1 MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTDSS SKKTKSSSEE
       61 SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT
      121 LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG SPQIPLADSE VEPSVIGHMS PIMTSPHSPG
      181 ASGNMERITS PVLMGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ
      241 EAKKHIPQLQ EQLSKATGSA QDGAVVTPSR PLGDTLTVSE AETDPGDVLG RTDCSSGDAS
      301 RPSSDNADSP KSGPKERIYL EENPEKSETI QDTDTQSLVG SPSTRIAPHI IGAEDDDFGT
      361 EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT LLCYLYSDLY KHTNSKETRR
      421 IFLEFHQFFL DRSAHLKVSV PDEMSADLEK RRPELIPEDL HRHYIQTMQE RVHPEVQRHL
      481 EDFRQKRSMG LTLAESELTK LDAERDKDRL TLEKERTCAE QIVAKIEEVL MTAQAVEEDK
      541 SSTMQYVILM YMKHLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDKEGEE KGKRRGFPSI
      601 LGPPRRPSRH DNSAIGRAME LQKARHPKHL STPSSVSPEP QDSAKLRQSG LANEGTDAGY
      661 LPANSMSSVA SGASFSQEGG KENDTGSKQV GETSAPGDTL DGTPRTLNTV FDFPPPPLDQ
      721 VQEEECEVER VTEHGTPKPF RKFDSVAFGE SQSEDEQFEN DLETDPPNWQ QLVSREVLLG
      781 LKPCEIKRQE VINELFYTER AHVRTLKVLD QVFYQRVSRE GILSPSELRK IFSNLEDILQ
      841 LHIGLNEQMK AVRKRNETSV IDQIGEDLLT WFSGPGEEKL KHAAATFCSN QPFALEMIKS
      901 RQKKDSRFQT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY TEWPTEREKV
      961 KKAADHCRQI LNYVNQAVKE AENKQRLEDY QRRLDTSSLK LSEYPNVEEL RNLDLTKRKM
     1021 IHEGPLVWKV NRDKTIDLYT LLLEDILVLL QKQDDRLVLR CHSKILASTA DSKHTFSPVI
     1081 KLSTVLVRQV ATDNKALFVI SMSDNGAQIY ELVAQTVSEK TVWQDLICRM AASVKEQSTK
     1141 PIPLPQSTPG EGDNDEEDPS KLKEEQHGIS VTGLQSPDRD LGLESTLISS KPQSHSLSTS
     1201 GKSEVRDLFV AERQFAKEQH TDGTLKEVGE DYQIAIPDSH LPVSEERWAL DALRNLGLLK
     1261 QLLVQQLGLT EKSVQEDWQH FPRYRTASQG PQTDSVIQNS ENIKAYHSGE GHMPFRTGTG
     1321 DIATCYSPRT STESFAPRDS VGLAPQDSQA SNILVMDHMI MTPEMPTMEP EGGLDDSGEH
     1381 FFDAREAHSD ENPSEGDGAV NKEEKDVNLR ISGNYLILDG YDPVQESSTD EEVASSLTLQ
     1441 PMTGIPAVES THQQQHSPQN THSDGAISPF TPEFLVQQRW GAMEYSCFEI QSPSSCADSQ
     1501 SQIMEYIHKI EADLEHLKKV EESYTILCQR LAGSALTDKH SDKS
//