LOCUS AAF06360.1 5373 aa PRT HUM 08-NOV-1999
DEFINITION Homo sapiens trabeculin-alpha protein.
ACCESSION AF141968-1
PROTEIN_ID AAF06360.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 17734)
AUTHORS Sun,Y., Zhang,J., Kraeft,S.K., Auclair,D., Chang,M.S., Liu,Y.,
Sutherland,R., Salgia,R., Griffin,J.D., Ferland,L.H. and Chen,L.B.
TITLE Molecular cloning and characterization of human trabeculin-alpha, a
giant protein defining a new family of actin-binding proteins
JOURNAL J. Biol. Chem. 274 (47), 33522-33530 (1999)
PUBMED 10559237
REFERENCE 2 (bases 1 to 17734)
AUTHORS Sun,Y., Zhang,J., Auclair,D. and Chen,L.B.
TITLE Direct Submission
JOURNAL Submitted (10-APR-1999) Cancer Biology, Dana-Farber Cancer
Institute, 44 Binney, Boston, MA 02115, USA
FEATURES Qualifiers
source /db_xref="H-InvDB:HIT000071191"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p33-p34.2"
protein /note="cytoskeletal giant protein; actin-binding protein"
BEGIN
1 MFPVLWAGIP GRDVGSLQPL PPGFKQFCTS ASRVAVIADE RDRVQKKTFT KWVNKHLMKV
61 RKHINDLYED LRDGHNLISL LEVLSGIKLP REKGRMRFHR LQNVQIALDF LKQRQVKLVN
121 IRNDDITDGN PKLTLGLIWT IILHFQISDI YISGESGDMS AKEKLLLWTQ KVTAGYTGIK
181 CTNFSSCWSD GKMFNALIHR YRPDLVDMER VQIQSNRENL EQAFEVAERL GVTRLLDAED
241 VDVPSPDEKS VITYVSSIYD AFPKVPEGGE GISATEVDSR WQEYQSRVDS LIPWIKQHTI
301 LMSDKTFPQN PVELKALYNQ YIHFKETEIL AKEREKGRIE ELYKLLEVWI EFGRIKLPQG
361 YHPNDVEEEW GKLIIEMLER EKSLRPAVER LELLLQIANK IQNGALNCEE KLTLAKNTLQ
421 ADAAHLESGQ PVQCESDVIM YIQECEGLIR QLQVDLQILR DENYYQLEEL AFRVMRLQDE
481 LVTLRLECTN LYRKGHFTSL ELVPPSTLTT THLKAEPLTK ATHSSSTSWF RKPMTRAELV
541 AISSSEDEGN LRFVYELLSW VEEMQMKLER AEWGNDLPSV ELQLETQQHI HTSVEELGSS
601 VKEARLYEGK MSQNFHTSYA ETLGKLETQY CKLKETSSFR MRHLQSLHKF VSRATAELIW
661 LNEKEEEELA YDWSDNNSNI SAKRNYFSEL TMELEEKQDV FRSLQDTAEL LSLENHPAKQ
721 TVEAYSAAVQ SQLQWMKQLC LCVEQHVKEN TAYFQFFSDA RELESFLRNL QDSIKRKYSC
781 DHNTSLSRLE DLLQDSMDEK EQLIQSKSSV ASLVGRSKTI VQLKPRSPDH VLKNTISVKA
841 VCDYRQIEIT ICKNDECVLE DNSQRTKWKV ISPTGNEAMV PSVCFLIPPP NKDAIEMASR
901 VEQSYQKVMA LWHQLHVNTK SLISWNYLRK DLDLVQTWNL EKLRSSAPGE CHQIMKNLQA
961 HYEDFLQDSR DSVLFSVADR LRLEEEVEAC KARFQHLMKS MENEDKEETV AKMYISELKN
1021 IRLRLEEYEQ RVVKRIQSLA SSRTDRDAWQ DNALRIAEQE HTQEDLQQLR SDLDAVSMKC
1081 DSFLHQSPSS SSVPTLRSEL NLLVEKMDHV YGLSTVYLNK LKTVDVIVRS IQDAELLVKG
1141 YEIKLSQEEV VLADLSALEA HWSTLRHWLS DVKDKNSVFS VLDEEIAKAK VVAEQMSRLT
1201 PERNLDLERY QEKGSQLQER WHRVIAQLEI RQSELESIQE VLGDYRACHG TLIKWIEETT
1261 AQQEMMKPGQ AEDSRVLSEQ LSQQTALFAE IERNQTKLDQ CQKFSQQYST IVKDYELQLM
1321 TYKAFVESQQ KSPGKRRRML SSSDAITQEF MDLRTRYTAL VTLTTQHVKY ISDALRRLEE
1381 EEKVVEEEKQ EHVEKVKELL GWVSTLARNT QGKATSSETK ESTDIEKAIL EQQVLSEELT
1441 TKKEQVSEAI KTSQIFLAKH GHKLSEKEKK QISEQLNALN KAYHDLCDGS ANQLQQLQSQ
1501 LAHQTEQKTL QKQQNTCHQQ LEDLCSWVGQ AERALAGHQG RTTQQDLSAL QKNQSDLKDL
1561 QDDIQNRATS FATVVKDIEG FMEENQTKLS PRELTALREK LHQAKEQYEA LQEETRVAQK
1621 ELEEAVTSAL QQETEKSKAA KELAENKKKI DALLDWVTSV GSSGGQLLTN LPGMEQLSGA
1681 SLEKGALDTT DGYMGVNQAP EKLDKQCEMM KARHQELLSQ QQNFILATQS AQAFLDQHGH
1741 NLTPEEQQML QQKLGELKEQ YSTSLAQSEA ELKQVQTLQD ELQKFLQDHK EFESWLERSE
1801 KELENMHKGG SSPETLPSLL KRQGSFSEDV ISHKGDLRFV TISGQKVLDM ENSFKEGKEP
1861 SEIGNLVKDK LKDATERYTA LHSKCTRLGS HLNMLLGQYH QFQNSADSLQ AWMQACEANV
1921 EKLLSDTVAS DPGVLQEQLA TTKQLQEELA EHQVPVEKLQ KVARDIMEIE GEPAPDHRHV
1981 QETTDSILSH FQSLSYSLAE RSSLLQKAIA QSQSVQESLE SLLQSIGEVE QNLEGKQVSS
2041 LSSGVIQKAL ATNMKLKQDI ARQKSSLEAT REMVTRFMET ADSTTAAVLQ GKLAEVSQRF
2101 EQLCLQQQEK ESSLKKLLPQ AEMFEHLSGK LQQFMENKSR MLASGNQPDQ DITHFFQQIQ
2161 ELNLEMEDQQ ENLDTLEHLV TELSSCGFAL DLCQHQDRVQ NLRKDFTELQ KTVKEREKDA
2221 SSCQEQLDEF RKLVRTFQKW LKETEGSIPP TETSVSAKEL EKQIEHLKSL LDDWASKGTL
2281 VEEINCKGTS LENLIMEITA PDSQGKTDLT EIQCDMSDVN LKYEKLGGVL HERQESLQAI
2341 LNRMEEVHKE ANSVLQWLES KEEVLKSMDA MSSPTKTETV KAQAESNKAF LAELEQNSPK
2401 IQKVKEALAG LLVTYPNSQE AENWKKIQEE LNSRWERATE VTVARQRQLE ESASHLACFQ
2461 AAESQLRPWL MEKELMMGVL GPLSIDPNML NAQKQQVQFM LKEFEARRQQ HEQLNEAAQG
2521 ILTGPGDVSL STSQVQKELQ SINQKWVELT DKLNSRSSQI DQAIVKSTQY QELLQDLSEK
2581 VRAVGQRLSV QSAISTQPEA VKQQLEETSE IRSDLEQLDH EVKEAQTLCD ELSVLIGEQY
2641 LKDELKKRLE TVALPLQGLE DLAADRINRL QAALASTQQF QQMFDELRTW LDDKQSQQAK
2701 NCPISAKLER LQSQLQENEE FQKSLNQHSG SYEVIVAEGE SLLLSVPPGE EKRTLQNQLV
2761 ELKNHWEELS KKTADRQSRL KDCMQKAQKY QWHVEDLVPW IEDCKAKMSE LRVTLDPVQL
2821 ESSLLRSKAM LNEVEKRRSL LEILNSAADI LINSSEADED GIRDEKAGIN QNMDAVTEEL
2881 QAKTGSLEEM TQRLREFQES FKNIEKKVEG AKHQLEIFDA LGSQACSNKN LEKLRAQQEV
2941 LQALEPQVDY LRNFTQGLVE DAPDGSDASQ LLHQAEVAQQ EFLEVKQRVN SGCVMMENKL
3001 EGIGQFHCRV REMFSQLADL DDELDGMGAI GRDTDSLQSQ IEDVRLFLNK IHVLKLDIEA
3061 SEAECRHMLE EEGTLDLLGL KRELEALNKQ CGKLTERGKA RQEQLELTLG RVEDFYRKLK
3121 GLNDATTAAE EAEALQWVVG TEVEIINQQL ADFKMFQKEQ VDPLQMKLQQ VNGLGQGLIQ
3181 SAGKDCDVQG LEHDMEEINA RWNTLNKKVA QRIAQLQEAL LHCGKFQDAL EPLLSWLADT
3241 EELIANQKPP SAEYKVVKAQ IQEQKLLQRL LDDRKATVDM LQAEGGRIAQ SAELADREKI
3301 TGQLESLESR WTELLSKAAA RQKQLEDILV LAKQFHETAE PISDFLSVTE KKLANSEPVG
3361 TQTAKIQQQI IRHKALEEDI ENHATDVHQA VKIGQSLSSL TSPAEQGVLS EKIDSLQARY
3421 SEIQDRCCRK AALLDQALSN ARLFGEDEVE VLNWLAEVED KLSSVFVKDF KQDVLHRQHA
3481 DHLALNEEIV NRKKNVDQAI KNGQALLKQT TGEEVLLIQE KLDGIKTRYA DITVTSSKAL
3541 RTLEQARQLA TKFQSTYEEL TGWLREVEEE LATSGGQSPT GEQIPQFQQR QKELKKEVME
3601 HRLVLDTVNE VSRALLELVP WRAREGLDKL VSDANEQYKL VSDTIGQRVD EIDAAIQRSQ
3661 QYEQAADAEL AWVAETKRKL MALGPIRLEQ DQTTAQLQVQ KAFSIDIIRH KDSMDELFSH
3721 RSEIFGTCGE EQKTVLQEKT ESLIQQYEAI SLLNSERYAR LERAQVLVNQ FWETYEELSP
3781 WIEETRALIA QLPSPAIDHE QLRQQQEEMR QLRESIAEHK PHIDKLLKIG PQLKELNPEE
3841 GEMVEEKYQK AENMYAQIKE EVRQRALALD EAVSQSTQIT EFHDKIEPML ETLENLSSRL
3901 RMPPLIPAEV DKIRECISDN KSATVELEKL QPSFEALKRR GEELIGRSQG ADKDLAAKEI
3961 QDKLDQMVFF WEDIKARAEE REIKFLDVLE LAEKFWYDMA ALLTTIKDTQ DIVHDLESPG
4021 IDPSIIKQQV EAAETIKEET DGLHEELEFI RILGADLIFA CGETEKPEVR KSIDEMNNAW
4081 ENLNKTWKER LEKLEDAMQA AVQYQDTLQA MFDWLDNTVI KLCTMPPVGT DLNTVKDQLN
4141 EMKEFKVEVY QQQIEMEKLN HQGELMLKKA TDETDRDIIR EPLTELKHLW ENLGEKIAHR
4201 QHKLEGALLA LGQFQHALEE LMSWLTHTEE LLDAQRPISG DPKVIEVELA KHHVLKNDVL
4261 AHQATVETVN KAGNELLESS AGDDASSLRS RLEAMNQCWE SVLQKTEERE QQLQSTLQQA
4321 QGFHSEIEDF LLELTRMESQ LSASKPTGGL PETAREQLDT HMELYSQLKA KEETYNQLLD
4381 KGRLMLLSRD DSGSGSKTEQ SVALLEQKWH VVSSKMEERK SKLEEALNLA TEFQNSLQEF
4441 INWLTLAEQS LNIASPPSLI LNTVLSQIEE HKVFANEVNA HRDQIIELDQ TGNQLKFLSQ
4501 KQDVVLIKNL LVSVQSRWEK VVQRSIERGR SLDDARKRAK QFHEAWKKLI DWLEDAESHL
4561 DSELEISNDP DKIKLQLSKH KEFQKTLGGK QPVYDTTIRT GRALKEKTLL PEDTQKLDNF
4621 LGEVRDKWDT VCGKSVERQH KLEEALLFSG QFMDALQALV DWLYKVEPQL AEDQPVHGDL
4681 DLVMNLMDAH KVFQKELGKR TGTVQVLKRS GRELIENSRD DTTWVKGQLQ ELSTRWDTVC
4741 KLSVSKQSRL EQALKQAEVF RDTVHMLLEW LSEAEQLRFR GALPDDTEAL QSLIDTHKEF
4801 MKKVEEKRVD VNSAVAMGEV ILAVCHPDCI TTIKHWITII RARFEEVLTW AKQHQQRLET
4861 ALSELVANAE LLEELLAWIQ WAETTLIQRD QEPIPQNIDR VKALIAEHQT FMEEMTRKQP
4921 DVDRVTKTYK RKNIEPTHAP FIEKSRSGGR KSLSQPTPPP MPILSQSEAK NPRINQLSAR
4981 WQQVWLLALE RQRKLNDALD RLEELKEFAN FDFDVWRKKY MRWMNHKKSR VMDFFRRIDK
5041 DQDGKITRQE FIDGILASKF PTTKLEMTAV ADIFDRDGDG YIDYYEFVAA LHPNKDAYRP
5101 TTDADKIEDE VTRQVAQCKC AKRFQVEQIG ENKYRFGDSQ QLRLVRILRS TVMVRVGGGW
5161 MALDEFLVKN DPCRARGRTN IELREKFILP EGASQGMTPF RSRGRRSKPS SRAASPTRSS
5221 SSASQSNHSC TSMPSSPATP ASGTKVIPSS GSKLKRPTPT FHSSRTSLAG DTSNSSSPAS
5281 TGAKTNRADP KKSASRPGSR AGSRAGSRAS SRRGSDASDF DLLETQSACS DTSESSAAGG
5341 QGNSRRGLNK PSKIPTMSKK TTTASPRTPG PKR
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