LOCUS       AAD41494.1               837 aa    PRT              HUM 30-JUN-1999
DEFINITION  Homo sapiens aggrecanase-1 protein.
ACCESSION   AF148213-1
PROTEIN_ID  AAD41494.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4193)
  AUTHORS   Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M.,
            Liu,R., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R.,
            Rockwell,A., Yang,F., Duke,J.L., Solomon,K., George,H.,
            Bruckner,R., Nagase,H., Itoh,Y., Ellis,D.M., Ross,H., Wiswall,B.H.,
            Murphy,K., Hillman,M.C. Jr., Hollis,G.F., Newton,R.C.,
            Magolda,R.L., Trzaskos,J.M. and Arner,E.C.
  TITLE     Purification and cloning of aggrecanase-1: a member of the ADAMTS
            family of proteins
  JOURNAL   Science 284 (5420), 1664-1666 (1999)
   PUBMED   10356395
REFERENCE   2  (bases 1 to 4193)
  AUTHORS   Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M.,
            Liu,R.-Q., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R.,
            Rockewell,A., Yang,F., Duke,J.L., Solomon,K., George,H.J.,
            Bruchner,R., Nagase,H., Ito,Y., Ellis,D.M., Ross,O.H.,
            Wiswall,B.H., Murphy,K., Hillman,M.C. Jr., Hollis,G.F.,
            Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Arner,E.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-1999) Applied Biotechnology, DuPont
            Pharmaceuticals Company, Experimental Station, E336/237B,
            Wilmington, DE 19880, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000071532"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     protein         /note="aggrecan degrading metalloproteinase-1; disintegrin
                     metalloproteinase; ADMP-1; ADAMTS-4"
BEGIN
        1 MSQTGSHPGR GLAGRWLWGA QPCLLLPIVP LSWLVWLLLL LLASLLPSAR LASPLPREEE
       61 IVFPEKLNGS VLPGSGAPAR LLCRLQAFGE TLLLELEQDS GVQVEGLTVQ YLGQAPELLG
      121 GAEPGTYLTG TINGDPESVA SLHWDGGALL GVLQYRGAEL HLQPLEGGTP NSAGGPGAHI
      181 LRRKSPASGQ GPMCNVKAPL GSPSPRPRRA KRFASLSRFV ETLVVADDKM AAFHGAGLKR
      241 YLLTVMAAAA KAFKHPSIRN PVSLVVTRLV ILGSGEEGPQ VGPSAAQTLR SFCAWQRGLN
      301 TPEDSDPDHF DTAILFTRQD LCGVSTCDTL GMADVGTVCD PARSCAIVED DGLQSAFTAA
      361 HELGHVFNML HDNSKPCISL NGPLSTSRHV MAPVMAHVDP EEPWSPCSAR FITDFLDNGY
      421 GHCLLDKPEA PLHLPVTFPG KDYDADRQCQ LTFGPDSRHC PQLPPPCAAL WCSGHLNGHA
      481 MCQTKHSPWA DGTPCGPAQA CMGGRCLHMD QLQDFNIPQA GGWGPWGPWG DCSRTCGGGV
      541 QFSSRDCTRP VPRNGGKYCE GRRTRFRSCN TEDCPTGSAL TFREEQCAAY NHRTDLFKSF
      601 PGPMDWVPRY TGVAPQDQCK LTCQARALGY YYVLEPRVVD GTPCSPDSSS VCVQGRCIHA
      661 GCDRIIGSKK KFDKCMVCGG DGSGCSKQSG SFRKFRYGYN NVVTIPAGAT HILVRQQGNP
      721 GHRSIYLALK LPDGSYALNG EYTLMPSPTD VVLPGAVSLR YSGATAASET LSGHGPLAQP
      781 LTLQVLVAGN PQDTRLRYSF FVPRPTPSTP RPTPQDWLHR RAQILEILRR RPWAGRK
//