LOCUS AAD41494.1 837 aa PRT HUM 30-JUN-1999 DEFINITION Homo sapiens aggrecanase-1 protein. ACCESSION AF148213-1 PROTEIN_ID AAD41494.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4193) AUTHORS Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M., Liu,R., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R., Rockwell,A., Yang,F., Duke,J.L., Solomon,K., George,H., Bruckner,R., Nagase,H., Itoh,Y., Ellis,D.M., Ross,H., Wiswall,B.H., Murphy,K., Hillman,M.C. Jr., Hollis,G.F., Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Arner,E.C. TITLE Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins JOURNAL Science 284 (5420), 1664-1666 (1999) PUBMED 10356395 REFERENCE 2 (bases 1 to 4193) AUTHORS Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M., Liu,R.-Q., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R., Rockewell,A., Yang,F., Duke,J.L., Solomon,K., George,H.J., Bruchner,R., Nagase,H., Ito,Y., Ellis,D.M., Ross,O.H., Wiswall,B.H., Murphy,K., Hillman,M.C. Jr., Hollis,G.F., Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Arner,E.C. TITLE Direct Submission JOURNAL Submitted (03-MAY-1999) Applied Biotechnology, DuPont Pharmaceuticals Company, Experimental Station, E336/237B, Wilmington, DE 19880, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000071532" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" protein /note="aggrecan degrading metalloproteinase-1; disintegrin metalloproteinase; ADMP-1; ADAMTS-4" BEGIN 1 MSQTGSHPGR GLAGRWLWGA QPCLLLPIVP LSWLVWLLLL LLASLLPSAR LASPLPREEE 61 IVFPEKLNGS VLPGSGAPAR LLCRLQAFGE TLLLELEQDS GVQVEGLTVQ YLGQAPELLG 121 GAEPGTYLTG TINGDPESVA SLHWDGGALL GVLQYRGAEL HLQPLEGGTP NSAGGPGAHI 181 LRRKSPASGQ GPMCNVKAPL GSPSPRPRRA KRFASLSRFV ETLVVADDKM AAFHGAGLKR 241 YLLTVMAAAA KAFKHPSIRN PVSLVVTRLV ILGSGEEGPQ VGPSAAQTLR SFCAWQRGLN 301 TPEDSDPDHF DTAILFTRQD LCGVSTCDTL GMADVGTVCD PARSCAIVED DGLQSAFTAA 361 HELGHVFNML HDNSKPCISL NGPLSTSRHV MAPVMAHVDP EEPWSPCSAR FITDFLDNGY 421 GHCLLDKPEA PLHLPVTFPG KDYDADRQCQ LTFGPDSRHC PQLPPPCAAL WCSGHLNGHA 481 MCQTKHSPWA DGTPCGPAQA CMGGRCLHMD QLQDFNIPQA GGWGPWGPWG DCSRTCGGGV 541 QFSSRDCTRP VPRNGGKYCE GRRTRFRSCN TEDCPTGSAL TFREEQCAAY NHRTDLFKSF 601 PGPMDWVPRY TGVAPQDQCK LTCQARALGY YYVLEPRVVD GTPCSPDSSS VCVQGRCIHA 661 GCDRIIGSKK KFDKCMVCGG DGSGCSKQSG SFRKFRYGYN NVVTIPAGAT HILVRQQGNP 721 GHRSIYLALK LPDGSYALNG EYTLMPSPTD VVLPGAVSLR YSGATAASET LSGHGPLAQP 781 LTLQVLVAGN PQDTRLRYSF FVPRPTPSTP RPTPQDWLHR RAQILEILRR RPWAGRK //