LOCUS AAD40849.2 747 aa PRT HUM 14-APR-2000 DEFINITION Homo sapiens sirtuin type 1 protein. ACCESSION AF083106-1 PROTEIN_ID AAD40849.2 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4086) AUTHORS Frye,R.A. TITLE Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity JOURNAL Biochem. Biophys. Res. Commun. 260 (1), 273-279 (1999) PUBMED 10381378 REFERENCE 2 (bases 1 to 4086) AUTHORS Frye,R.A. TITLE Direct Submission JOURNAL Submitted (10-AUG-1998) Pathology, VA Med. Cent. (132L), Univ. of Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA REFERENCE 3 (bases 1 to 4086) AUTHORS Frye,R.A. TITLE Direct Submission JOURNAL Submitted (14-APR-2000) Pathology, VA Med. Cent. (132L), Univ. of Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA REMARK Sequence update by submitter COMMENT On Apr 14, 2000 this sequence version replaced AF083106.1. FEATURES Qualifiers source /db_xref="H-InvDB:HIT000066539" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="testis" protein /gene="SIRT1" /note="yeast silent information regulator 2 (Sir2p) homolog" BEGIN 1 MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV 61 PAAARGCPGA AAAALWREAE AEAAAAGGEQ EAQATAAAGE GDNGPGLQGP SREPPLADNL 121 YDEDDDDEGE EEEEAAAAAI GYRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP 181 RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI 241 NTIEDAVKLL QECKKIIVLT GAGVSVSCGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE 301 YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII 361 QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE 421 QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG 481 DCDVIINELC HRLGGEYAKL CCNPVKLSEI TEKPPRTQKE LAYLSELPPT PLHVSEDSSS 541 PERTSPPDSS VIVTLLDQAA KSNDDLDVSE SKGCMEEKPQ EVQTSRNVES IAEQMENPDL 601 KNVGSSTGEK NERTSVAGTV RKCWPNRVAK EQISRRLDGN QYLFLPPNRY IFHGAEVYSD 661 SEDDVLSSSS CGSNSDSGTC QSPSLEEPME DESEIEEFYN GLEDEPDVPE RAGGAGFGTD 721 GDDQEAINEA ISVKQEVTDM NYPSNKS //