LOCUS       AAD40849.2               747 aa    PRT              HUM 14-APR-2000
DEFINITION  Homo sapiens sirtuin type 1 protein.
ACCESSION   AF083106-1
PROTEIN_ID  AAD40849.2
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4086)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem. Biophys. Res. Commun. 260 (1), 273-279 (1999)
   PUBMED   10381378
REFERENCE   2  (bases 1 to 4086)
  AUTHORS   Frye,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-1998) Pathology, VA Med. Cent. (132L), Univ. of
            Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
REFERENCE   3  (bases 1 to 4086)
  AUTHORS   Frye,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-APR-2000) Pathology, VA Med. Cent. (132L), Univ. of
            Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
  REMARK    Sequence update by submitter
COMMENT     On Apr 14, 2000 this sequence version replaced AF083106.1.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000066539"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="testis"
     protein         /gene="SIRT1"
                     /note="yeast silent information regulator 2 (Sir2p)
                     homolog"
BEGIN
        1 MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV
       61 PAAARGCPGA AAAALWREAE AEAAAAGGEQ EAQATAAAGE GDNGPGLQGP SREPPLADNL
      121 YDEDDDDEGE EEEEAAAAAI GYRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP
      181 RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI
      241 NTIEDAVKLL QECKKIIVLT GAGVSVSCGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE
      301 YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII
      361 QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE
      421 QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG
      481 DCDVIINELC HRLGGEYAKL CCNPVKLSEI TEKPPRTQKE LAYLSELPPT PLHVSEDSSS
      541 PERTSPPDSS VIVTLLDQAA KSNDDLDVSE SKGCMEEKPQ EVQTSRNVES IAEQMENPDL
      601 KNVGSSTGEK NERTSVAGTV RKCWPNRVAK EQISRRLDGN QYLFLPPNRY IFHGAEVYSD
      661 SEDDVLSSSS CGSNSDSGTC QSPSLEEPME DESEIEEFYN GLEDEPDVPE RAGGAGFGTD
      721 GDDQEAINEA ISVKQEVTDM NYPSNKS
//