LOCUS AAC99767.1 233 aa PRT HUM 11-MAY-1999 DEFINITION Homo sapiens CARD-containing apoptotic signaling protein protein. ACCESSION AF082283-1 PROTEIN_ID AAC99767.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2810) AUTHORS Zhang,Q., Siebert,R., Yan,M., Hinzmann,B., Cui,X., Xue,L., Rakestraw,K.M., Naeve,C.W., Beckmann,G., Weisenburger,D.D., Sanger,W.G., Nowotny,H., Vesely,M., Callet-Bauchu,E., Salles,G., Dixit,V.M., Rosenthal,A., Schlegelberger,B. and Morris,S.W. TITLE Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) JOURNAL Nat. Genet. 22 (1), 63-68 (1999) PUBMED 10319863 REFERENCE 2 (bases 1 to 2810) AUTHORS Morris,S.W., Cui,X., Zhang,Q., Rakestraw,K. and Naeve,C. TITLE Direct Submission JOURNAL Submitted (04-AUG-1998) Experimental Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale Ave., Memphis, TN 38105, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000066514" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1p22" /tissue_type="spleen" protein /gene="BCL10" /note="B-cell CLL/lymphoma 10; similar to equine herpesvirus-2 ORF E10; overexpressed due to juxtaposition to the IgH enhancer in the t(1;14)(p22;q32) in MALT lymphomas; wild-type BCL10 gene promotes apoptotic cell death and induces NF-kappaB activation; a variety of mutations that inactivate the pro-apoptotic function of the gene, but in many cases leave NF-kappaB activation intact, occur in MALT lymphomas and other tumors of various types" BEGIN 1 MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 61 SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS 121 SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG 181 RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ //