LOCUS       AAC99767.1               233 aa    PRT              HUM 11-MAY-1999
DEFINITION  Homo sapiens CARD-containing apoptotic signaling protein protein.
ACCESSION   AF082283-1
PROTEIN_ID  AAC99767.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Zhang,Q., Siebert,R., Yan,M., Hinzmann,B., Cui,X., Xue,L.,
            Rakestraw,K.M., Naeve,C.W., Beckmann,G., Weisenburger,D.D.,
            Sanger,W.G., Nowotny,H., Vesely,M., Callet-Bauchu,E., Salles,G.,
            Dixit,V.M., Rosenthal,A., Schlegelberger,B. and Morris,S.W.
  TITLE     Inactivating mutations and overexpression of BCL10, a caspase
            recruitment domain-containing gene, in MALT lymphoma with
            t(1;14)(p22;q32)
  JOURNAL   Nat. Genet. 22 (1), 63-68 (1999)
   PUBMED   10319863
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Morris,S.W., Cui,X., Zhang,Q., Rakestraw,K. and Naeve,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-1998) Experimental Oncology, St. Jude Children's
            Research Hospital, 332 N. Lauderdale Ave., Memphis, TN 38105, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000066514"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22"
                     /tissue_type="spleen"
     protein         /gene="BCL10"
                     /note="B-cell CLL/lymphoma 10; similar to equine
                     herpesvirus-2 ORF E10; overexpressed due to juxtaposition
                     to the IgH enhancer in the t(1;14)(p22;q32) in MALT
                     lymphomas; wild-type BCL10 gene promotes apoptotic cell
                     death and induces NF-kappaB activation; a variety of
                     mutations that inactivate the pro-apoptotic function of
                     the gene, but in many cases leave NF-kappaB activation
                     intact, occur in MALT lymphomas and other tumors of
                     various types"
BEGIN
        1 MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS
       61 SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS
      121 SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG
      181 RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
//