LOCUS       AAC51668.1               760 aa    PRT              HUM 14-AUG-1997
DEFINITION  Homo sapiens integral membrane serine protease Seprase protein.
ACCESSION   U76833-1
PROTEIN_ID  AAC51668.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M.,
            Yeh,Y., Flessate,D. and Chen,W.T.
  TITLE     Molecular cloning of seprase: a serine integral membrane protease
            from human melanoma
  JOURNAL   Biochim. Biophys. Acta 1361 (1), 11-19 (1997)
   PUBMED   9247085
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M.,
            Yeh,Y., Flessate,D. and Chen,W.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-1996) Cell Biology, Georgetown University Medical
            School, 3970 Reservoir Road N.W., Washington, DC 20007, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000221322"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="amelanotic melanoma; LOX"
     protein         /note="170 kDa homodimeric gelatinase; member of the
                     nonclassical serine hydrolase family; synthesized by
                     RT-PCR using Fibroblast Activation Protein alpha (FAP
                     alpha) primers"
BEGIN
        1 MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN
       61 WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK
      121 LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP
      181 FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG
      241 DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT
      301 DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD
      361 AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG
      421 RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR
      481 TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV
      541 YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ
      601 ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY
      661 TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA
      721 QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD
//