LOCUS AAC50152.1 826 aa PRT HUM 28-JUN-1995 DEFINITION Homo sapiens hypoxia-inducible factor 1 alpha protein. ACCESSION U22431-1 PROTEIN_ID AAC50152.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3678) AUTHORS Wang,G.L., Jiang,B.H., Rue,E.A. and Semenza,G.L. TITLE Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5510-5514 (1995) PUBMED 7539918 REFERENCE 2 (bases 1 to 3678) AUTHORS Wang,G.L., Jiang,B.-H., Rue,E.A. and Semenza,G.L. TITLE Direct Submission JOURNAL Submitted (09-MAR-1995) Gregg L. Semenza, Center for Medical Genetics, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287-3914, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000218685" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="Hep3B" /cell_type="hepatoblastoma" protein /gene="HIF-1 alpha" /standard_name="hypoxia-inducible factor 1, alpha subunit" /note="basic helix-loop-helix transcription factor" BEGIN 1 MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM 61 RLTISYLRVR KLLDAGDLDI EDDMKAQMNC FYLKALDGFV MVLTDDGDMI YISDNVNKYM 121 GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGLVKKGKE QNTQRSFFLR MKCTLTSRGR 181 TMNIKSATWK VLHCTGHIHV YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK 241 TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 301 TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL IFSLQQTECV 361 LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL APAAGDTIIS LDFGSNDTET 421 DDQQLEEVPL YNDVMLPSPN EKLQNINLAM SPLPTAETPK PLRSSADPAL NQEVALKLEP 481 NPESLELSFT MPQIQDQTPS PSDGSTRQSS PEPNSPSEYC FYVDSDMVNE FKLELVEKLF 541 AEDTEAKNPF STQDTDLDLE MLAPYIPMDD DFQLRSFDQL SPLESSSASP ESASPQSTVT 601 VFQQTQIQEP TANATTTTAT TDELKTVTKD RMEDIKILIA SPSPTHIHKE TTSATSSPYR 661 DTQSRTASPN RAGKGVIEQT EKSHPRSPNV LSVALSQRTT VPEEELNPKI LALQNAQRKR 721 KMEHDGSLFQ AVGIGTLLQQ PDDHAATTSL SWKRVKGCKS SEQNGMEQKT IILIPSDLAC 781 RLLGQSMDES GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN //