LOCUS AAC41772.1 1487 aa PRT HUM 03-AUG-1995
DEFINITION Homo sapiens alpha-1 type II collagen protein.
ACCESSION L10347-1
PROTEIN_ID AAC41772.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Cheah,K.S., Stoker,N.G., Griffin,J.R., Grosveld,F.G. and Solomon,E.
TITLE Identification and characterization of the human type II collagen
gene (COL2A1)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (9), 2555-2559 (1985)
PUBMED 3857598
REFERENCE 2 (sites)
AUTHORS Baldwin,C.T., Reginato,A.M., Smith,C., Jimenez,S.A. and
Prockop,D.J.
TITLE Structure of cDNA clones coding for human type II procollagen. The
alpha 1(II) chain is more similar to the alpha 1(I) chain than two
other alpha chains of fibrillar collagens
JOURNAL Biochem. J. 262 (2), 521-528 (1989)
PUBMED 2803268
REFERENCE 3 (sites)
AUTHORS Vikkula,M. and Peltonen,L.
TITLE Structural analyses of the polymorphic area in type II collagen
gene
JOURNAL FEBS Lett. 250 (2), 171-174 (1989)
PUBMED 2753125
REFERENCE 4 (sites)
AUTHORS Ryan,M.C., Sieraski,M. and Sandell,L.J.
TITLE The human type II procollagen gene: identification of an additional
protein-coding domain and location of potential regulatory
sequences in the promoter and first intron
JOURNAL Genomics 8 (1), 41-48 (1990)
PUBMED 2081599
REFERENCE 5 (sites)
AUTHORS Huang,M.C., Seyer,J.M., Thompson,J.P., Spinella,D.G., Cheah,K.S.
and Kang,A.H.
TITLE Genomic organization of the human procollagen alpha 1(II) collagen
gene
JOURNAL Eur. J. Biochem. 195 (3), 593-600 (1991)
PUBMED 1999183
REFERENCE 6 (sites)
AUTHORS Vikkula,M., Metsaranta,M., Syvanen,A.C., Ala-Kokko,L., Vuorio,E.
and Peltonen,L.
TITLE Structural analysis of the regulatory elements of the type-II
procollagen gene. Conservation of promoter and first intron
sequences between human and mouse
JOURNAL Biochem. J. 285 (Pt 1), 287-294 (1992)
PUBMED 1637314
REFERENCE 7 (sites)
AUTHORS Ala-Kokko,L., Kvist,A.P., Metsaranta,M., Kivirikko,K.I., de
Crombrugghe,B., Prockop,D.J. and Vuorio,E.
TITLE Conservation of the sizes of 53 introns and over 100 intronic
sequences for the binding of common transcription factors in the
human and mouse genes for type II procollagen (COL2A1)
JOURNAL Biochem. J. 308 (Pt 3), 923-929 (1995)
PUBMED 8948452
COMMENT Original source text: Homo sapiens male adult blood DNA.
Bases Reported in References
REFERENCE 1 (bases 26401-26754,26809-26980,27089-27253,
27308-27488,
27597-27840,27895-28337,28446-31001)
AUTHORS Cheah, Kathryn S E, Stoker, Neil G, Griffin, Jane R,
Grosveld, Frank G, and Solomon Ellen
TITLE Identification and Characterization of the Human Type II
Collagen Gene (COL2A1)
JOURNAL Proc. Natl. Acad. Sci, USA 82, 2555-2559 (1985) REFERENCE
2 (bases 1-85,5892-5908,6122-6154,6259-6291,6397-6450,
6614-6715,7694-7771,8399-8443,8555-8608,9009-9062, 9838-9891,
10266-10319,10451-10504,10811-10855, 11391-11444,14507-14551,
15031-15084,16598-16696, 16993-17037,17130-17228,17418-17471,
17996-18103, 18469-18522,18607-18705,18846-18899,19340-19438,
19832-19885,20292-20345,20696-20749,20993-21046, 21289-21333,
21480-21578,21813-21920,22263-22316, 22595-22648,23025-23078,
23451-23504,23759-23866, 24358-24411,24856-24909,25656-25817,
26015-26122, 26293-26400,26755-26808,26981-27088,27254-27307,
27489-27596,27841-27894,28338-28445)
AUTHORS Baldwin, Clinton T, Reginato, Anthony M, Smith, Carol,
Jiminez, Sergio A, and Prockop, Darwin J
TITLE Structure of cDNA clones coding for human type II
procollagen. The alpha1(II) chain is more similar to the alpha1(I)
chain two other alpha chains of fibrillar collagen JOURNAL
Biochemical Journal 262, 521-528 (1989)
REFERENCE 3 (bases 86-4190)
AUTHORS Vikkula, Miikka, Metsaranta, Marjo, Syvanen,
Ann-Cristine, Ala-Kokko, Leena, Vuorio, Eero, and Peltonen, Leena
TITLE Structural analysis of the regulatory elements of the
type-II procollagen gene
JOURNAL Biochemical Journal 285, 287-294 (1992)
REFERENCE 4 (bases 4191-5891)
AUTHORS Ryan, Maureen C, Sieraski, Madelyn, and Sandell, Linda J
TITLE The Human Type II Procollagen Gene: Identification of an
Additional Protein-Coding Domain and Location of Potential
Regulatory Sequences in the Promoter and First Intron JOURNAL
Genomics 8, 41-48 (1990)
REFERENCE 5 (bases 20346-20695,20750-20992,21047-21288,
21334-21479, 21579-21812,21921-22262)
AUTHORS Vikkula, Miikka and Peltonen, Leena
TITLE Structural Analyses of the Polymorphic Area in Type II
Collagen Gene
JOURNAL FEBS LETTERS 250, 2:171-174 (1989)
REFERENCE 6 (bases 5909-6121, 6155-6258, 6292-6396,6451-6613,
6716-7693,7772-8398,8444-85541-30997)
AUTHORS Huang, Min-Chi, Seyer, Jerome M, Thompson, James P,
Spinella, Dominic G, Ceah, Kathy S E, Kang, Andrew H TITLE
Genomic Organization of the Human Procollagen a1(II) Collagen Gene
JOURNAL FEBS LETTERS 195, 593-600 (1991)
REFERENCE 7 (bases 8609-9008,9063-9837,9892-10265,10320-10450,
10505-10810,10856-11390,11445-14506,14552-15030,
15085-16597,16697-16992,17038-17129,17229-17417,
17472-17995,18104-18468,18523-18606,18706-18845, 18900-19339,
19439-19831,19886-20291,22317-22594, 22649-23024,23079-23450,
23505-23758,23867-24357, 24412-24855,24910-25655,25818-26014,
26123-26292)
AUTHORS Leena Ala-Kokko, Ari-Pekka Kvist, Marjo Metsaranta, Kari
Kivirikko,Benoit de Crombrugghe, Darwin J. Prockop, and Eero
Vuorio.
TITLE Comparison of the Human and Mouse Genes for Type II
Procollagen (COL2A1). conservation of the relative Sizes of 54
Introns, about 70% of 25,000 Base Sequences of the Introns and Over
One Hundred Sites Throughout the Gene for Binding of Common
Transcription Factors
JOURNAL Manuscript, in preparation.
FEATURES Qualifiers
source /organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="12q13"
/sex="male"
/cell_type="leukocyte"
/tissue_type="blood"
/dev_stage="adult"
protein /gene="COL2A1"
/db_xref="GDB:G00-119-063"
intron_pos 29:1 (1/53)
intron_pos 98:1 (2/53)
intron_pos 104:0 (3/53)
intron_pos 115:0 (4/53)
intron_pos 126:0 (5/53)
intron_pos 144:0 (6/53)
intron_pos 178:0 (7/53)
intron_pos 204:0 (8/53)
intron_pos 219:0 (9/53)
intron_pos 237:0 (10/53)
intron_pos 255:0 (11/53)
intron_pos 273:0 (12/53)
intron_pos 291:0 (13/53)
intron_pos 309:0 (14/53)
intron_pos 324:0 (15/53)
intron_pos 342:0 (16/53)
intron_pos 357:0 (17/53)
intron_pos 375:0 (18/53)
intron_pos 408:0 (19/53)
intron_pos 423:0 (20/53)
intron_pos 456:0 (21/53)
intron_pos 474:0 (22/53)
intron_pos 510:0 (23/53)
intron_pos 528:0 (24/53)
intron_pos 561:0 (25/53)
intron_pos 579:0 (26/53)
intron_pos 612:0 (27/53)
intron_pos 630:0 (28/53)
intron_pos 648:0 (29/53)
intron_pos 666:0 (30/53)
intron_pos 684:0 (31/53)
intron_pos 699:0 (32/53)
intron_pos 732:0 (33/53)
intron_pos 768:0 (34/53)
intron_pos 786:0 (35/53)
intron_pos 804:0 (36/53)
intron_pos 822:0 (37/53)
intron_pos 840:0 (38/53)
intron_pos 876:0 (39/53)
intron_pos 894:0 (40/53)
intron_pos 912:0 (41/53)
intron_pos 966:0 (42/53)
intron_pos 1002:0 (43/53)
intron_pos 1038:0 (44/53)
intron_pos 1056:0 (45/53)
intron_pos 1092:0 (46/53)
intron_pos 1110:0 (47/53)
intron_pos 1146:0 (48/53)
intron_pos 1164:0 (49/53)
intron_pos 1200:0 (50/53)
intron_pos 1296:1 (51/53)
intron_pos 1359:0 (52/53)
intron_pos 1440:0 (53/53)
BEGIN
1 MIRLGAPQSL VLLTLLVAAV LRCQGQDVQE AGSCVQDGQR YNDKDVWKPE PCRICVCDTG
61 TVLCDDIICE DVKDCLSPEI PFGECCPICP TDLATASGQP GPKGQKGEPG DIKDIVGPKG
121 PPGPQGPAGE QGPRGDRGDK GEKGAPGPRG RDGEPGTPGN PGPPGPPGPP GPPGLGGNFA
181 AQMAGGFDEK AGGAQLGVMQ GPMGPMGPRG PPGPAGAPGP QGFQGNPGEP GEPGVSGPMG
241 PRGPPGPPGK PGDDGEAGKP GKAGERGPPG PQGARGFPGT PGLPGVKGHR GYPGLDGAKG
301 EAGAPGVKGE SGSPGENGSP GPMGPRGLPG ERGRTGPAGA AGARGNDGQP GPAGPPGPVG
361 PAGGPGFPGA PGAKGEAGPT GARGPEGAQG PRGEPGTPGS PGPAGASGNP GTDGIPGAKG
421 SAGAPGIAGA PGFPGPRGPP GPQGATGPLG PKGQTGEPGI AGFKGEQGPK GEPGPAGPQG
481 APGPAGEEGK RGARGEPGGV GPIGPPGERG APGNRGFPGQ DGLAGPKGAP GERGPSGLAG
541 PKGANGDPGR PGEPGLPGAR GLTGRPGDAG PQGKVGPSGA PGEDGRPGPP GPQGARGQPG
601 VMGFPGPKGA NGEPGKAGEK GLPGAPGLRG LPGKDGETGA AGPPGPAGPA GERGEQGAPG
661 PSGFQGLPGP PGPPGEGGKP GDQGVPGEAG APGLVGPRGE RGFPGERGSP GAQGLQGPRG
721 LPGTPGTDGP KGASGPAGPP GAQGPPGLQG MPGERGAAGI AGPKGDRGDV GEKGPEGAPG
781 KDGGRGLTGP IGPPGPAGAN GEKGEVGPPG PAGSAGARGA PGERGETGPP GPAGFAGPPG
841 ADGQPGAKGE QGEAGQKGDA GAPGPQGPSG APGPQGPTGV TGPKGARGAQ GPPGATGFPG
901 AAGRVGPPGS NGNPGPPGPP GPSGKDGPKG ARGDSGPPGR AGEPGLQGPA GPPGEKGEPG
961 DDGPSGAEGP PGPQGLAGQR GIVGLPGQRG ERGFPGLPGP SGEPGKQGAP GASGDRGPPG
1021 PVGPPGLTGP AGEPGREGSP GADGPPGRDG AAGVKGDRGE TGAVGAPGAP GPPGSPGPAG
1081 PTGKQGDRGE AGAQGPMGPS GPAGARGIQG PQGPRGDKGE AGEPGERGLK GHRGFTGLQG
1141 LPGPPGPSGD QGASGPAGPS GPRGPPGPVG PSGKDGANGI PGPIGPPGPR GRSGETGPAG
1201 PPGNPGPPGP PGPPGPGIDM SAFAGLGPRE KGPDPLQYMR ADQAAGGLRQ HDAEVDATLK
1261 SLNNQIESIR SPEGSRKNPA RTCRDLKLCH PEWKSGDYWI DPNQGCTLDA MKVFCNMETG
1321 ETCVYPNPAN VPKKNWWSSK SKEKKHIWFG ETINGGFHFS YGDDNLAPNT ANVQMTFLRL
1381 LSTEGSQNIT YHCKNSIAYL DEAAGNLKKA LLIQGSNDVE IRAEGNSRFT YTALKDGCTK
1441 HTGKWGKTVI EYRSQKTSRL PIIDIAPMDI GGPEQEFGVD IGPVCFL
//