LOCUS       AAB69423.1              1279 aa    PRT              HUM 03-SEP-1997
DEFINITION  Homo sapiens P-glycoprotein protein.
ACCESSION   AF016535-1
PROTEIN_ID  AAB69423.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I.,
            Gottesman,M.M. and Roninson,I.B.
  TITLE     Internal duplication and homology with bacterial transport proteins
            in the mdr1 (P-glycoprotein) gene from multidrug-resistant human
            cells
  JOURNAL   Cell 47 (3), 381-389 (1986)
   PUBMED   2876781
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Chen,G., Duran,G.E., Steger,K.A., Lacayo,N.J., Jaffrezou,J.P.,
            Dumontet,C. and Sikic,B.I.
  TITLE     Multidrug-resistant human sarcoma cells with a mutant
            P-glycoprotein, altered phenotype, and resistance to cyclosporins
  JOURNAL   J. Biol. Chem. 272 (9), 5974-5982 (1997)
   PUBMED   9038218
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Chen,G., Lacayo,N.J., Steger,K.A. and Sikic,B.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-1997) Medicine, Stanford University School of
            Medicine, Stanford, CA 94306, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000062400"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.1"
                     /clone="8.1"
                     /cell_line="MES-SA/DxP"
                     /cell_type="drug-resistant uterine sarcoma"
     protein         /gene="mdr1"
                     /function="transporter protein"
                     /note="multidrug-resistance"
BEGIN
        1 MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII
       61 HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG
      121 IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS
      181 KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT
      241 DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
      301 AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFSVLIG AFSVGQASPS IEAFANARGA
      361 AYEIFKIIDN KPSIDSYSKS GHKPDNIKGN LEFRNVHFSY PSRKEVKILK GLNLKVQSGQ
      421 TVALVGNSGC GKSTTVQLMQ RLYDPTEGMV SVDGQDIRTI NVRFLREIIG VVSQEPVLFA
      481 TTIAENIRYG RENVTMDEIE KAVKEANAYD FIMKLPHKFD TLVGERGAQL SGGQKQRIAI
      541 ARALVRNPKI LLLDEATSAL DTESEAVVQV ALDKARKGRT TIVIAHRLST VRNADVIAGF
      601 DDGVIVEKGN HDELMKEKGI YFKLVTMQTA GNEVELENAA DESKSEIDAL EMSSNDSRSS
      661 LIRKRSTRRS VRGSQAQDRK LSTKEALDES IPPVSFWRIM KLNLTEWPYF VVGVFCAIIN
      721 GGLQPAFAII FSKIIGVFTR IDDPETKRQN SNLFSLLFLA LGIISFITFF LQGFTFGKAG
      781 EILTKRLRYM VFRSMLRQDV SWFDDPKNTT GALTTRLAND AAQVKGAIGS RLAVITQNIA
      841 NLGTGIIISF IYGWQLTLLL LAIVPIIAIA GVVEMKMLSG QALKDKKELE GAGKIATEAI
      901 ENFRTVVSLT QEQKFEHMYA QSLQVPYRNS LRKAHIFGIT FSFTQAMMYF SYAGCFRFGA
      961 YLVAHKLMSF EDVLLVFSAV VFGAMAVGQV SSFAPDYAKA KISAAHIIMI IEKTPLIDSY
     1021 STEGLMPNTL EGNVTFGEVV FNYPTRPDIP VLQGLSLEVK KGQTLALVGS SGCGKSTVVQ
     1081 LLERFYDPLA GKVLLDGKEI KRLNVQWLRA HLGIVSQEPI LFDCSIAENI AYGDNSRVVS
     1141 QEEIVRAAKE ANIHAFIESL PNKYSTKVGD KGTQLSGGQK QRIAIARALV RQPHILLLDE
     1201 ATSALDTESE KVVQEALDKA REGRTCIVIA HRLSTIQNAD LIVVFQNGRV KEHGTHQQLL
     1261 AQKGIYFSMV SVQAGTKRQ
//