LOCUS AAB69423.1 1279 aa PRT HUM 03-SEP-1997 DEFINITION Homo sapiens P-glycoprotein protein. ACCESSION AF016535-1 PROTEIN_ID AAB69423.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4192) AUTHORS Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I., Gottesman,M.M. and Roninson,I.B. TITLE Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells JOURNAL Cell 47 (3), 381-389 (1986) PUBMED 2876781 REFERENCE 2 (bases 1 to 4192) AUTHORS Chen,G., Duran,G.E., Steger,K.A., Lacayo,N.J., Jaffrezou,J.P., Dumontet,C. and Sikic,B.I. TITLE Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins JOURNAL J. Biol. Chem. 272 (9), 5974-5982 (1997) PUBMED 9038218 REFERENCE 3 (bases 1 to 4192) AUTHORS Chen,G., Lacayo,N.J., Steger,K.A. and Sikic,B.I. TITLE Direct Submission JOURNAL Submitted (28-JUL-1997) Medicine, Stanford University School of Medicine, Stanford, CA 94306, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000062400" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7q21.1" /clone="8.1" /cell_line="MES-SA/DxP" /cell_type="drug-resistant uterine sarcoma" protein /gene="mdr1" /function="transporter protein" /note="multidrug-resistance" BEGIN 1 MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 61 HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 121 IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 181 KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 241 DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 301 AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFSVLIG AFSVGQASPS IEAFANARGA 361 AYEIFKIIDN KPSIDSYSKS GHKPDNIKGN LEFRNVHFSY PSRKEVKILK GLNLKVQSGQ 421 TVALVGNSGC GKSTTVQLMQ RLYDPTEGMV SVDGQDIRTI NVRFLREIIG VVSQEPVLFA 481 TTIAENIRYG RENVTMDEIE KAVKEANAYD FIMKLPHKFD TLVGERGAQL SGGQKQRIAI 541 ARALVRNPKI LLLDEATSAL DTESEAVVQV ALDKARKGRT TIVIAHRLST VRNADVIAGF 601 DDGVIVEKGN HDELMKEKGI YFKLVTMQTA GNEVELENAA DESKSEIDAL EMSSNDSRSS 661 LIRKRSTRRS VRGSQAQDRK LSTKEALDES IPPVSFWRIM KLNLTEWPYF VVGVFCAIIN 721 GGLQPAFAII FSKIIGVFTR IDDPETKRQN SNLFSLLFLA LGIISFITFF LQGFTFGKAG 781 EILTKRLRYM VFRSMLRQDV SWFDDPKNTT GALTTRLAND AAQVKGAIGS RLAVITQNIA 841 NLGTGIIISF IYGWQLTLLL LAIVPIIAIA GVVEMKMLSG QALKDKKELE GAGKIATEAI 901 ENFRTVVSLT QEQKFEHMYA QSLQVPYRNS LRKAHIFGIT FSFTQAMMYF SYAGCFRFGA 961 YLVAHKLMSF EDVLLVFSAV VFGAMAVGQV SSFAPDYAKA KISAAHIIMI IEKTPLIDSY 1021 STEGLMPNTL EGNVTFGEVV FNYPTRPDIP VLQGLSLEVK KGQTLALVGS SGCGKSTVVQ 1081 LLERFYDPLA GKVLLDGKEI KRLNVQWLRA HLGIVSQEPI LFDCSIAENI AYGDNSRVVS 1141 QEEIVRAAKE ANIHAFIESL PNKYSTKVGD KGTQLSGGQK QRIAIARALV RQPHILLLDE 1201 ATSALDTESE KVVQEALDKA REGRTCIVIA HRLSTIQNAD LIVVFQNGRV KEHGTHQQLL 1261 AQKGIYFSMV SVQAGTKRQ //