LOCUS       AAB60391.1               278 aa    PRT              HUM 12-JAN-2001
DEFINITION  Homo sapiens unknown protein.
ACCESSION   U07000-4
PROTEIN_ID  AAB60391.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 152141)
  AUTHORS   Chissoe,S.L., Bodenteich,A., Wang,Y.F., Wang,Y.P., Burian,D.,
            Clifton,S.W., Crabtree,J., Freeman,A., Iyer,K., Jian,L., Ma,Y.,
            McLaury,H.-J., Pan,H.-Q., Sarhan,O.H., Toth,S., Wang,Z., Zhang,G.,
            Heisterkamp,N., Groffen,J. and Roe,B.A.
  TITLE     Sequence and analysis of the human ABL gene, the BCR gene, and
            regions involved in the Philadelphia chromosomal translocation
  JOURNAL   Genomics 27 (1), 67-82 (1995)
   PUBMED   7665185
REFERENCE   2  (bases 14590 to 16317; 87877 to 88058; 95028 to 95132; 95433 to
            95618; 102486 to 102593; 105610 to 105670; 107159 to 107211; 107712
            to 107852; 118055 to 118176; 119111 to 119279; 121237 to 121356;
            122175 to 122250; 123595 to 123699; 124417 to 124491; 126619 to
            126716; 129102 to 129233; 143502 to 143561; 144402 to 144511;
            145775 to 145914; 146965 to 147099; 148046 to 148151; 148630 to
            148792; 149511 to 150035)
  AUTHORS   Heisterkamp,N., Stam,K., Groffen,J., de Klein,A. and Grosveld,G.
  TITLE     Structural organization of the bcr gene and its role in the Ph'
            translocation
  JOURNAL   Nature 315 (6022), 758-761 (1985)
   PUBMED   2989703
REFERENCE   3  (sites)
  AUTHORS   Hariharan,I.K. and Adams,J.M.
  TITLE     cDNA sequence for human bcr, the gene that translocates to the abl
            oncogene in chronic myeloid leukaemia
  JOURNAL   EMBO J. 6 (1), 115-119 (1987)
   PUBMED   3107980
REFERENCE   4  (bases 14443 to 16317; 87877 to 88058; 95028 to 95132; 95433 to
            95618; 102486 to 102593; 105610 to 105670; 107159 to 107211; 107712
            to 107852; 118055 to 118176; 119111 to 119279; 121237 to 121356;
            122175 to 122250; 123595 to 123699; 124417 to 124491; 126619 to
            126716; 143502 to 143561; 144402 to 144511; 145775 to 145914;
            146965 to 147099; 148046 to 148151; 148630 to 148792; 149511 to
            150028)
  AUTHORS   Lifshitz,B., Fainstein,E., Marcelle,C., Shtivelman,E., Amson,R.,
            Gale,R.P. and Canaani,E.
  TITLE     bcr genes and transcripts
  JOURNAL   Oncogene 2 (2), 113-117 (1988)
   PUBMED   3285291
REFERENCE   5  (sites)
  AUTHORS   Mount,S.M.
  TITLE     A catalogue of splice junction sequences
  JOURNAL   Nucleic Acids Res. 10 (2), 459-472 (1982)
   PUBMED   7063411
REFERENCE   6  (sites)
  AUTHORS   Romero,P., Beran,M., Shtalrid,M., Andersson,B., Talpaz,M. and
            Blick,M.
  TITLE     Alternative 5' end of the bcr-abl transcript in chronic myelogenous
            leukemia
  JOURNAL   Oncogene 4 (1), 93-98 (1989)
   PUBMED   2915904
REFERENCE   7  (bases 13586 to 15175; 15861 to 16371)
  AUTHORS   Zhu,Q.S., Heisterkamp,N. and Groffen,J.
  TITLE     Unique organization of the human BCR gene promoter
  JOURNAL   Nucleic Acids Res. 18 (23), 7119-7125 (1990)
   PUBMED   2263470
REFERENCE   8  (bases 14288 to 15050)
  AUTHORS   Shah,N.P., Witte,O.N. and Denny,C.T.
  TITLE     Characterization of the BCR promoter in Philadelphia
            chromosome-positive and -negative cell lines
  JOURNAL   Mol. Cell. Biol. 11 (4), 1854-1860 (1991)
   PUBMED   1900918
REFERENCE   9  (bases 29622 to 33758)
  AUTHORS   Romero,P. and Colombatti,A.
  JOURNAL   Unpublished
REFERENCE   10  (bases 68407 to 69776)
  AUTHORS   Denny,C.T., Shah,N.P., Ogden,S., Willman,C., McConnell,T.,
            Crist,W., Carroll,A. and Witte,O.N.
  TITLE     Localization of preferential sites of rearrangement within the BCR
            gene in Philadelphia chromosome-positive acute lymphoblastic
            leukemia
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (11), 4254-4258 (1989)
   PUBMED   2567002
REFERENCE   11  (bases 69715 to 69950)
  AUTHORS   van der Feltz,M.J., Shivji,M.K., Allen,P.B., Heisterkamp,N.,
            Groffen,J. and Wiedemann,L.M.
  TITLE     Nucleotide sequence of both reciprocal translocation junction
            regions in a patient with Ph positive acute lymphoblastic
            leukaemia, with a breakpoint within the first intron of the BCR
            gene
  JOURNAL   Nucleic Acids Res. 17 (1), 1-10 (1989)
   PUBMED   2911461
REFERENCE   12  (bases 70497 to 70847)
  AUTHORS   Papadopoulos,P.C., Greenstein,A.M., Gaffney,R.A., Westbrook,C.A.
            and Wiedemann,L.M.
  TITLE     Characterization of the translocation breakpoint sequences in
            Philadelphia-positive acute lymphoblastic leukemia
  JOURNAL   Genes Chromosomes Cancer 1 (3), 233-239 (1990)
   PUBMED   2083218
REFERENCE   13  (bases 73813 to 76835)
  AUTHORS   Chen,S.J., Chen,Z., d'Auriol,L., Le Coniat,M., Grausz,D. and
            Berger,R.
  TITLE     Ph1+bcr- acute leukemias: implication of Alu sequences in a
            chromosomal translocation occurring in the new cluster region
            within the BCR gene
  JOURNAL   Oncogene 4 (2), 195-202 (1989)
   PUBMED   2648256
REFERENCE   14  (bases 121621 to 126622)
  AUTHORS   Sowerby,S.J., Kennedy,M.A., Fitzgerald,P.H. and Morris,C.M.
  TITLE     DNA sequence analysis of the major breakpoint cluster region of the
            BCR gene rearranged in Philadelphia-positive human leukemias
  JOURNAL   Oncogene 8 (6), 1679-1683 (1993)
   PUBMED   8502487
REFERENCE   15  (sites)
  AUTHORS   Uberbacher,E.C. and Mural,R.J.
  TITLE     Locating protein-coding regions in human DNA sequences by a
            multiple sensor-neural network approach
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 88 (24), 11261-11265 (1991)
   PUBMED   1763041
REFERENCE   16  (sites)
  AUTHORS   Takeda,J., Yano,H., Eng,S., Zeng,Y. and Bell,G.I.
  TITLE     A molecular inventory of human pancreatic islets: sequence analysis
            of 1000 cDNA clones
  JOURNAL   Hum. Mol. Genet. 2 (11), 1793-1798 (1993)
   PUBMED   7506601
REFERENCE   17  (sites)
  AUTHORS   Chen,S.J., Chen,Z., Font,M.P., d'Auriol,L., Larsen,C.J. and
            Berger,R.
  TITLE     Structural alterations of the BCR and ABL genes in Ph1 positive
            acute leukemias with rearrangements in the BCR gene first intron:
            further evidence implicating Alu sequences in the chromosome
            translocation
  JOURNAL   Nucleic Acids Res. 17 (19), 7631-7642 (1989)
   PUBMED   2678002
REFERENCE   18  (sites)
  AUTHORS   Groffen,J., Stephenson,J.R., Heisterkamp,N., de Klein,A.,
            Bartram,C.R. and Grosveld,G.
  TITLE     Philadelphia chromosomal breakpoints are clustered within a limited
            region, bcr, on chromosome 22
  JOURNAL   Cell 36 (1), 93-99 (1984)
   PUBMED   6319012
REFERENCE   19  (sites)
  AUTHORS   Chissoe,S.L.
  TITLE     Sequence of the human abl and bcr genes
  JOURNAL   Thesis (1994) University of Oklahoma
REFERENCE   20  (sites)
  AUTHORS   Litz,C.E., McClure,J.S., Copenhaver,C.M. and Brunning,R.D.
  TITLE     Duplication of small segments within the major breakpoint cluster
            region in chronic myelogenous leukemia
  JOURNAL   Blood 81 (6), 1567-1572 (1993)
   PUBMED   8453102
REFERENCE   21  (sites)
  AUTHORS   de Klein,A., van Agthoven,T., Groffen,C., Heisterkamp,N.,
            Groffen,J. and Grosveld,G.
  TITLE     Molecular analysis of both translocation products of a
            Philadelphia-positive CML patient
  JOURNAL   Nucleic Acids Res. 14 (17), 7071-7082 (1986)
   PUBMED   3463934
REFERENCE   22  (sites)
  AUTHORS   Mills,K.I., Sproul,A.M., Ogilvie,D., Elvin,P., Leibowitz,D. and
            Burnett,A.K.
  TITLE     Amplification and sequencing of genomic breakpoints located within
            the M-bcr region by Vectorette-mediated polymerase chain reaction
  JOURNAL   Leukemia 6 (5), 481-483 (1992)
   PUBMED   1317490
REFERENCE   23  (sites)
  AUTHORS   Groffen,J., Heisterkamp,N., Grosveld,F., Van de Ven,W. and
            Stephenson,J.R.
  TITLE     Isolation of human oncogene sequences (v-fes homolog) from a cosmid
            library
  JOURNAL   Science 216 (4550), 1136-1138 (1982)
   PUBMED   6281890
REFERENCE   24  (sites)
  AUTHORS   Soekarman,D., van Denderen,J., Hoefsloot,L., Moret,M., Meeuwsen,T.,
            van Baal,J., Hagemeijer,A. and Grosveld,G.
  TITLE     A novel variant of the bcr-abl fusion product in Philadelphia
            chromosome-positive acute lymphoblastic leukemia
  JOURNAL   Leukemia 4 (6), 397-403 (1990)
   PUBMED   2193202
REFERENCE   25  (sites)
  AUTHORS   Heisterkamp,N., Stephenson,J.R., Groffen,J., Hansen,P.F., de
            Klein,A., Bartram,C.R. and Grosveld,G.
  TITLE     Localization of the c-ab1 oncogene adjacent to a translocation
            break point in chronic myelocytic leukaemia
  JOURNAL   Nature 306 (5940), 239-242 (1983)
   PUBMED   6316147
REFERENCE   26  (sites)
  AUTHORS   Grosveld,G., Verwoerd,T., van Agthoven,T., de Klein,A.,
            Ramachandran,K.L., Heisterkamp,N., Stam,K. and Groffen,J.
  TITLE     The chronic myelocytic cell line K562 contains a breakpoint in bcr
            and produces a chimeric bcr/c-abl transcript
  JOURNAL   Mol. Cell. Biol. 6 (2), 607-616 (1986)
   PUBMED   3023859
REFERENCE   27  (sites)
  AUTHORS   Morris,C.M., Heisterkamp,N., Groffen,J. and Fitzgerald,P.H.
  TITLE     Entire ABL gene is joined with 5'-BCR in some patients with
            Philadelphia-positive leukemia
  JOURNAL   Blood 78 (4), 1078-1084 (1991)
   PUBMED   1868241
REFERENCE   28  (sites)
  AUTHORS   Heisterkamp,N., Knoppel,E. and Groffen,J.
  TITLE     The first BCR gene intron contains breakpoints in Philadelphia
            chromosome positive leukemia
  JOURNAL   Nucleic Acids Res. 16 (21), 10069-10081 (1988)
   PUBMED   3194194
REFERENCE   29  (sites)
  AUTHORS   Tatusov,R. and Lipman,D.J.
  TITLE     Using local similarities for pattern detection in
            nucleotide/protein sequences
  JOURNAL   Unpublished
REFERENCE   30  (bases 1 to 152141)
  AUTHORS   Roe,B.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-FEB-1994) Bruce A. Roe, Dept. of Chemistry and
            Biochemistry, University of Oklahoma, 620 Parrington Oval, Room
            208, Norman, OK 73019, USA
FEATURES             Qualifiers
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11"
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="22q11"
                     /clone="cos 7-1"
                     /cell_line="K562 CML"
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="Bridge-2"
                     /cell_line="K562 CML"
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="RK2-2"
                     /cell_line="K562 CML"
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /clone="KBP5"
                     /cell_line="K562 CML"
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="22q11"
                     /clone="CA-22"
                     /cell_line="human lung carcinoma tissue"
     protein         /gene="BCR"
                     /note="ORF in intron 4, is within a GRAIL predicted
                     excellent exon and has homology with GenBank Accession
                     Numbers T10559, T11065 and T11428"
                     /citation=[15]
                     /citation=[16]
BEGIN
        1 RGGSEGRGRG REKRARGARR KRKQGGREAR AADGEGGSGP GAEAGARTRP REEAEGGGSV
       61 EEGARGIIKG DEGSVGAGKE AQGRKYGKEE WRVRARRREG ARPGRVQGQG GQVWAYIPGT
      121 GAAMAAAARE EEEEAARESA ACPAAGPALW RLPEVLLLHM CSYLDMRALG RLAQVYRWLW
      181 HFTNCDLLRR QIAWASLNSG FTRLGTNLMT SVPVKVSQNW IVGCCREGIL LKWRCSQMPW
      241 MQLEDDALYI SQANFILAYQ FRPDGASLNR QPLGVCWA
//