LOCUS       AAB51366.1              1025 aa    PRT              HUM 04-APR-1997
DEFINITION  Homo sapiens dihydropyrimidine dehydrogenase protein.
ACCESSION   U20938-1
PROTEIN_ID  AAB51366.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   Diasio,R.B., Beavers,T.L. and Carpenter,J.T.
  TITLE     Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical
            basis for familial pyrimidinemia and severe 5-fluorouracil-induced
            toxicity
  JOURNAL   J. Clin. Invest. 81 (1), 47-51 (1988)
   PUBMED   3335642
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Lu,Z.H., Zhang,R. and Diasio,R.B.
  TITLE     Purification and characterization of dihydropyrimidine
            dehydrogenase from human liver
  JOURNAL   J. Biol. Chem. 267 (24), 17102-17109 (1992)
   PUBMED   1512248
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Johnson,M.R., Albin,N., Shahinian,H. and Diasio,R.B.
  TITLE     Identification of a frameshift in the DNA coding for
            dihydropyrimidine dehydrogenase (DPD) in a DPD deficient patient
            exhibiting 5-fluorouracil toxicity
  JOURNAL   Unpublished
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Johnson,M.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-1995) Pharmacology, University of Alabama at
            Birmingham, 1670 University Blvd., Birmingham, AL 35294-0019, USA
COMMENT     On Apr 4, 1997 this sequence version replaced gi:693911.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000218575"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_type="lymphocyte"
     protein         /EC_number="1.2.1.2"
                     /note="DPD; dihydrouracil dehydrogenase"
BEGIN
        1 MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD
       61 DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN
      121 PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE
      181 KMSEAYSAKI ALFGAGPASI SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV
      241 VNFEIELMKD LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTQD
      301 QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS ALRCGARRVF
      361 IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG GRIVAMQFVR TEQDETGKWN
      421 EDEDQMVHLK ADVVISAFGS VLSDPKVKEA LSPIKFNRWG LPEVDPETMQ TSEAWVFAGG
      481 DVVGLANTTV ESVNDGKQAS WYIHKYVQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAGL
      541 KFINPFGLAS ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY
      601 GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW TELAKKSEDS
      661 GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVQIPFFAKL TPNVTDIVSI
      721 ARAAKEGGAN GVTATNTVSG LMGLKSDGTP WPAVGIAKRT TYGGVSGTAI RPIALRAVTS
      781 IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL
      841 KSIEELQDWD GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ
      901 NVAFSPLKRN CFIPKRPIPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE EMCINCGKCY
      961 MTCNDSGYQA IQFDPETHLP TITDTCTGCT LCLSVCPIVD CIKMVSRTTP YEPKRGVPLS
     1021 VNPVC
//