LOCUS AAB50261.1 78 aa PRT VRL 21-OCT-2002
DEFINITION Human immunodeficiency virus 1 protein ( Human immunodeficiency
virus type 1 (HXB2), complete genome; HIV1/HTLV-III/LAV
reference genome. ).
ACCESSION K03455-4
PROTEIN_ID AAB50261.1
SOURCE Human immunodeficiency virus 1 (HIV-1)
ORGANISM Human immunodeficiency virus 1
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
REFERENCE 1 (sites)
AUTHORS van Beveren,C.P., Coffin,J. and Hughes,S.
TITLE Appendix B: HTLV-3/LAV genome
JOURNAL (in) Weiss,R.L., Teich,N., Varmus,H. and Coffin,J. (Eds.);
RNA TUMOR VIRUSES, SECOND EDITION, 2, Vol. 2: 1102-1123;
Cold Spring Harbor Laboratory, Cold Spring Harbor (1985)
REFERENCE 2 (bases 493 to 674; 9577 to 9718)
AUTHORS Ratner,L., Haseltine,W., Patarca,R., Livak,K.J., Starcich,B.,
Josephs,S.F., Doran,E.R., Rafalski,J.A., Whitehorn,E.A.,
Baumeister,K., Ivanoff,L., Petteway,S.R. Jr., Pearson,M.L.,
Lautenberger,J.A., Papas,T.S., Ghrayeb,J., Chang,N.T., Gallo,R.C.
and Wong-Staal,F.
TITLE Complete nucleotide sequence of the AIDS virus, HTLV-III
JOURNAL Nature 313 (6000), 277-284 (1985)
PUBMED 2578615
REFERENCE 3 (bases 1 to 653)
AUTHORS Starcich,B., Ratner,L., Josephs,S.F., Okamoto,T., Gallo,R.C. and
Wong-Staal,F.
TITLE Characterization of long terminal repeat sequences of HTLV-III
JOURNAL Science 227 (4686), 538-540 (1985)
PUBMED 2981438
REFERENCE 4 (sites)
AUTHORS Allan,J.S., Coligan,J.E., Barin,F., McLane,M.F., Sodroski,J.G.,
Rosen,C.A., Haseltine,W.A., Lee,T.H. and Essex,M.
TITLE Major glycoprotein antigens that induce antibodies in AIDS patients
are encoded by HTLV-III
JOURNAL Science 228 (4703), 1091-1094 (1985)
PUBMED 2986290
REFERENCE 5 (sites)
AUTHORS Rosen,C.A., Sodroski,J.G. and Haseltine,W.A.
TITLE The location of cis-acting regulatory sequences in the human T cell
lymphotropic virus type III (HTLV-III/LAV) long terminal repeat
JOURNAL Cell 41 (3), 813-823 (1985)
PUBMED 2988790
REFERENCE 6 (sites)
AUTHORS Arya,S.K., Guo,C., Josephs,S.F. and Wong-Staal,F.
TITLE Trans-activator gene of human T-lymphotropic virus type III
(HTLV-III)
JOURNAL Science 229 (4708), 69-73 (1985)
PUBMED 2990040
REFERENCE 7 (sites)
AUTHORS Sodroski,J., Patarca,R., Rosen,C., Wong-Staal,F. and Haseltine,W.
TITLE Location of the trans-activating region on the genome of human
T-cell lymphotropic virus type III
JOURNAL Science 229 (4708), 74-77 (1985)
PUBMED 2990041
REFERENCE 8 (sites)
AUTHORS Rabson,A.B., Daugherty,D.F., Venkatesan,S., Boulukos,K.E.,
Benn,S.I., Folks,T.M., Feorino,P. and Martin,M.A.
TITLE Transcription of novel open reading frames of AIDS retrovirus
during infection of lymphocytes
JOURNAL Science 229 (4720), 1388-1390 (1985)
PUBMED 2994220
REFERENCE 9 (sites)
AUTHORS Allan,J.S., Coligan,J.E., Lee,T.H., McLane,M.F., Kanki,P.J.,
Groopman,J.E. and Essex,M.
TITLE A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS
patients
JOURNAL Science 230 (4727), 810-813 (1985)
PUBMED 2997921
REFERENCE 10 (sites)
AUTHORS Rosen,C.A., Sodroski,J.G., Goh,W.C., Dayton,A.I., Lippke,J. and
Haseltine,W.A.
TITLE Post-transcriptional regulation accounts for the trans-activation
of the human T-lymphotropic virus type III
JOURNAL Nature 319 (6054), 555-559 (1986)
PUBMED 3003584
REFERENCE 11 (sites)
AUTHORS di Marzo Veronese,F., Copeland,T.D., DeVico,A.L., Rahman,R.,
Oroszlan,S., Gallo,R.C. and Sarngadharan,M.G.
TITLE Characterization of highly immunogenic p66/p51 as the reverse
transcriptase of HTLV-III/LAV
JOURNAL Science 231 (4743), 1289-1291 (1986)
PUBMED 2418504
REFERENCE 12 (sites)
AUTHORS Kramer,R.A., Schaber,M.D., Skalka,A.M., Ganguly,K., Wong-Staal,F.
and Reddy,E.P.
TITLE HTLV-III gag protein is processed in yeast cells by the virus
pol-protease
JOURNAL Science 231 (4745), 1580-1584 (1986)
PUBMED 2420008
REFERENCE 13 (sites)
AUTHORS Dayton,A.I., Sodroski,J.G., Rosen,C.A., Goh,W.C. and Haseltine,W.A.
TITLE The trans-activator gene of the human T cell lymphotropic virus
type III is required for replication
JOURNAL Cell 44 (6), 941-947 (1986)
PUBMED 2420471
REFERENCE 14 (sites)
AUTHORS Lee,T.H., Coligan,J.E., Allan,J.S., McLane,M.F., Groopman,J.E. and
Essex,M.
TITLE A new HTLV-III/LAV protein encoded by a gene found in cytopathic
retroviruses
JOURNAL Science 231 (4745), 1546-1549 (1986)
PUBMED 3006243
REFERENCE 15 (sites)
AUTHORS Sodroski,J., Goh,W.C., Rosen,C., Tartar,A., Portetelle,D., Burny,A.
and Haseltine,W.
TITLE Replicative and cytopathic potential of HTLV-III/LAV with sor gene
deletions
JOURNAL Science 231 (4745), 1549-1553 (1986)
PUBMED 3006244
REFERENCE 16 (sites)
AUTHORS Kan,N.C., Franchini,G., Wong-Staal,F., DuBois,G.C., Robey,W.G.,
Lautenberger,J.A. and Papas,T.S.
TITLE Identification of HTLV-III/LAV sor gene product and detection of
antibodies in human sera
JOURNAL Science 231 (4745), 1553-1555 (1986)
PUBMED 3006245
REFERENCE 17 (sites)
AUTHORS Arya,S.K. and Gallo,R.C.
TITLE Three novel genes of human T-lymphotropic virus type III: immune
reactivity of their products with sera from acquired immune
deficiency syndrome patients
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (7), 2209-2213 (1986)
PUBMED 3008154
REFERENCE 18 (sites)
AUTHORS Jones,K.A., Kadonaga,J.T., Luciw,P.A. and Tjian,R.
TITLE Activation of the AIDS retrovirus promoter by the cellular
transcription factor, Sp1
JOURNAL Science 232 (4751), 755-759 (1986)
PUBMED 3008338
REFERENCE 19 (sites)
AUTHORS Sodroski,J., Goh,W.C., Rosen,C., Dayton,A., Terwilliger,E. and
Haseltine,W.
TITLE A second post-transcriptional trans-activator gene required for
HTLV-III replication
JOURNAL Nature 321 (6068), 412-417 (1986)
PUBMED 3012355
REFERENCE 20 (sites)
AUTHORS Starcich,B.R., Hahn,B.H., Shaw,G.M., McNeely,P.D., Modrow,S.,
Wolf,H., Parks,E.S., Parks,W.P., Josephs,S.F., Gallo,R.C. and
Wong-Staal,F.
TITLE Identification and characterization of conserved and variable
regions in the envelope gene of HTLV-III/LAV, the retrovirus of
AIDS
JOURNAL Cell 45 (5), 637-648 (1986)
PUBMED 2423250
REFERENCE 21 (sites)
AUTHORS Willey,R.L., Rutledge,R.A., Dias,S., Folks,T., Theodore,T.,
Buckler,C.E. and Martin,M.A.
TITLE Identification of conserved and divergent domains within the
envelope gene of the acquired immunodeficiency syndrome retrovirus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (14), 5038-5042 (1986)
PUBMED 3014529
REFERENCE 22 (bases 8761 to 9060)
AUTHORS Fisher,A.G., Ratner,L., Mitsuya,H., Marselle,L.M., Harper,M.E.,
Broder,S., Gallo,R.C. and Wong-Staal,F.
TITLE Infectious mutants of HTLV-III with changes in the 3' region and
markedly reduced cytopathic effects
JOURNAL Science 233 (4764), 655-659 (1986)
PUBMED 3014663
REFERENCE 23 (sites)
AUTHORS Feinberg,M.B., Jarrett,R.F., Aldovini,A., Gallo,R.C. and
Wong-Staal,F.
TITLE HTLV-III expression and production involve complex regulation at
the levels of splicing and translation of viral RNA
JOURNAL Cell 46 (6), 807-817 (1986)
PUBMED 3638988
REFERENCE 24 (sites)
AUTHORS Lightfoote,M.M., Coligan,J.E., Folks,T.M., Fauci,A.S., Martin,M.A.
and Venkatesan,S.
TITLE Structural characterization of reverse transcriptase and
endonuclease polypeptides of the acquired immunodeficiency syndrome
retrovirus
JOURNAL J. Virol. 60 (2), 771-775 (1986)
PUBMED 2430111
REFERENCE 25 (sites)
AUTHORS Terwilliger,E., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A.
TITLE Effects of mutations within the 3' orf open reading frame region of
human T-cell lymphotropic virus type III (HTLV-III/LAV) on
replication and cytopathogenicity
JOURNAL J. Virol. 60 (2), 754-760 (1986)
PUBMED 3490583
REFERENCE 26 (sites)
AUTHORS Wright,C.M., Felber,B.K., Paskalis,H. and Pavlakis,G.N.
TITLE Expression and characterization of the trans-activator of
HTLV-III/LAV virus
JOURNAL Science 234 (4779), 988-992 (1986)
PUBMED 3490693
REFERENCE 27 (sites)
AUTHORS Patarca,R., Heath,C., Goldenberg,G.J., Rosen,C.A., Sodroski,J.G.,
Haseltine,W.A. and Hansen,U.M.
TITLE Transcription directed by the HIV long terminal repeat in vitro
JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 41-55 (1987)
PUBMED 3040054
REFERENCE 28 (bases 1 to 9635)
AUTHORS Ratner,L., Fisher,A., Jagodzinski,L.L., Mitsuya,H., Liou,R.S.,
Gallo,R.C. and Wong-Staal,F.
TITLE Complete nucleotide sequences of functional clones of the AIDS
virus
JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 57-69 (1987)
PUBMED 3040055
REFERENCE 29 (sites)
AUTHORS Wong-Staal,F., Chanda,P.K. and Ghrayeb,J.
TITLE Human immunodeficiency virus: the eighth gene
JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 33-39 (1987)
PUBMED 3476127
REFERENCE 30 (sites)
AUTHORS Modrow,S., Hahn,B.H., Shaw,G.M., Gallo,R.C., Wong-Staal,F. and
Wolf,H.
TITLE Computer-assisted analysis of envelope protein sequences of seven
human immunodeficiency virus isolates: prediction of antigenic
epitopes in conserved and variable regions
JOURNAL J. Virol. 61 (2), 570-578 (1987)
PUBMED 2433466
REFERENCE 31 (sites)
AUTHORS Goh,W.C., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A.
TITLE Expression of the art gene protein of human T-lymphotropic virus
type III (HTLV-III/LAV) in bacteria
JOURNAL J. Virol. 61 (2), 633-637 (1987)
PUBMED 3543401
REFERENCE 32 (sites)
AUTHORS Muesing,M.A., Smith,D.H. and Capon,D.J.
TITLE Regulation of mRNA accumulation by a human immunodeficiency virus
trans-activator protein
JOURNAL Cell 48 (4), 691-701 (1987)
PUBMED 3643816
REFERENCE 33 (sites)
AUTHORS Nabel,G. and Baltimore,D.
TITLE An inducible transcription factor activates expression of human
immunodeficiency virus in T cells
JOURNAL Nature 326 (6114), 711-713 (1987)
PUBMED 3031512
REMARK Erratum:[Nature 1990 Mar 8;344(6262):178]
REFERENCE 34 (sites)
AUTHORS Fisher,A.G., Ensoli,B., Ivanoff,L., Chamberlain,M., Petteway,S.,
Ratner,L., Gallo,R.C. and Wong-Staal,F.
TITLE The sor gene of HIV-1 is required for efficient virus transmission
in vitro
JOURNAL Science 237 (4817), 888-893 (1987)
PUBMED 3497453
REFERENCE 35 (bases 6225 to 8795)
AUTHORS Reitz,M.S. Jr., Wilson,C., Naugle,C., Gallo,R.C. and
Robert-Guroff,M.
TITLE Generation of a neutralization-resistant variant of HIV-1 is due to
selection for a point mutation in the envelope gene
JOURNAL Cell 54 (1), 57-63 (1988)
PUBMED 2838179
REFERENCE 36 (bases 790 to 2292)
AUTHORS Pal,R., Reitz,M.S. Jr., Tschachler,E., Gallo,R.C.,
Sarngadharan,M.G. and Veronese,F.D.
TITLE Myristoylation of gag proteins of HIV-1 plays an important role in
virus assembly
JOURNAL AIDS Res. Hum. Retroviruses 6 (6), 721-730 (1990)
PUBMED 2194551
REFERENCE 37 (sites)
AUTHORS Ido,E., Han,H.P., Kezdy,F.J. and Tang,J.
TITLE Kinetic studies of human immunodeficiency virus type 1 protease and
its active-site hydrogen bond mutant A28S
JOURNAL J. Biol. Chem. 266 (36), 24359-24366 (1991)
PUBMED 1761538
COMMENT On Mar 25, 1997 this sequence version replaced gi:327742.
[6] sites; tat mRNA and other transcript boundaries. [7] sites;
tat mRNA.
[8] sites; mRNA splice sites.
[9] sites; 27K antigen cds.
[5] sites; gp160 and gp120 coding sequences.
[1] sites; regulatory sequences in the LTR.
[(in) Weiss,R., Teich,N., Varmus,H. and Coffin,J. (Eds.);RNA Tumor
Viruses, Secon] review; bases 1 to 9718.
[15] sites; trans-activator function and TAR sequence. [19]
sites; pol coding sequence.
[22] sites; 23K sor gene product.
[23] sites; pol NH2-terminal region.
[20] sites; sor 23K protein.
[21] sites; sor 23K protein.
[24] sites; Sp1 binding sites in the promoter region. [17] sites;
acceptor and donor splice sites for tat and 27K. [10] sites;
deletion mutants in the tat gene.
[18] sites; env gene conserved/varable regions; separate entries.
[16] sites; trs cds boundaries.
[12] sites; trs cds boundaries.
[11] sites; env gene conserved/variable regions; separate entries.
[26] sites; tar or transactivator target.
[13] sites; 3' orf mutations.
[14] sites; pol p34 terminus.
[31] sites; promoter, TAR, tat-III mutants.
[32] sites; envelope protein epitopes.
[33] sites; trs/art protein.
[34] sites; inducible enhancer element.
[27] revises [30].
[29] sites; long terminal repeat.
[28] sites; R orf.
[35] sites; sor.
Sequence for [25] kindly provided in computer-readable form by
L.Ratner, 19-AUG-1986.
The HXB2 sequence is being used as a reference genome for all the
HIV entries because it has been derived from a demonstrably
infectious clone. Hence not all of the 'sites' references above
were concerned with this isolate.
FEATURES Qualifiers
source /organism="Human immunodeficiency virus 1"
/proviral
/mol_type="genomic RNA"
/isolate="HXB2"
/db_xref="taxon:11676"
/note="HTLV-III/LAV"
protein /note="R (ORF) protein"
BEGIN
1 MEQAPEDQGP QREPHNEWTL ELLEELKNEA VRHFPRIWLH GLGQHIYETY GDTWAGVEAI
61 IRILQQLLFI HFQNWVST
//