LOCUS       AAB50256.1                86 aa    PRT              VRL 21-OCT-2002
DEFINITION  Human immunodeficiency virus 1 protein ( Human immunodeficiency
            virus type 1 (HXB2), complete genome; HIV1/HTLV-III/LAV
            reference genome. ).
ACCESSION   K03455-5
PROTEIN_ID  AAB50256.1
SOURCE      Human immunodeficiency virus 1 (HIV-1)
  ORGANISM  Human immunodeficiency virus 1
            Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
REFERENCE   1  (sites)
  AUTHORS   van Beveren,C.P., Coffin,J. and Hughes,S.
  TITLE     Appendix B: HTLV-3/LAV genome
  JOURNAL   (in) Weiss,R.L., Teich,N., Varmus,H. and Coffin,J. (Eds.);
            RNA TUMOR VIRUSES, SECOND EDITION, 2, Vol. 2: 1102-1123;
            Cold Spring Harbor Laboratory, Cold Spring Harbor (1985)
REFERENCE   2  (bases 493 to 674; 9577 to 9718)
  AUTHORS   Ratner,L., Haseltine,W., Patarca,R., Livak,K.J., Starcich,B.,
            Josephs,S.F., Doran,E.R., Rafalski,J.A., Whitehorn,E.A.,
            Baumeister,K., Ivanoff,L., Petteway,S.R. Jr., Pearson,M.L.,
            Lautenberger,J.A., Papas,T.S., Ghrayeb,J., Chang,N.T., Gallo,R.C.
            and Wong-Staal,F.
  TITLE     Complete nucleotide sequence of the AIDS virus, HTLV-III
  JOURNAL   Nature 313 (6000), 277-284 (1985)
   PUBMED   2578615
REFERENCE   3  (bases 1 to 653)
  AUTHORS   Starcich,B., Ratner,L., Josephs,S.F., Okamoto,T., Gallo,R.C. and
            Wong-Staal,F.
  TITLE     Characterization of long terminal repeat sequences of HTLV-III
  JOURNAL   Science 227 (4686), 538-540 (1985)
   PUBMED   2981438
REFERENCE   4  (sites)
  AUTHORS   Allan,J.S., Coligan,J.E., Barin,F., McLane,M.F., Sodroski,J.G.,
            Rosen,C.A., Haseltine,W.A., Lee,T.H. and Essex,M.
  TITLE     Major glycoprotein antigens that induce antibodies in AIDS patients
            are encoded by HTLV-III
  JOURNAL   Science 228 (4703), 1091-1094 (1985)
   PUBMED   2986290
REFERENCE   5  (sites)
  AUTHORS   Rosen,C.A., Sodroski,J.G. and Haseltine,W.A.
  TITLE     The location of cis-acting regulatory sequences in the human T cell
            lymphotropic virus type III (HTLV-III/LAV) long terminal repeat
  JOURNAL   Cell 41 (3), 813-823 (1985)
   PUBMED   2988790
REFERENCE   6  (sites)
  AUTHORS   Arya,S.K., Guo,C., Josephs,S.F. and Wong-Staal,F.
  TITLE     Trans-activator gene of human T-lymphotropic virus type III
            (HTLV-III)
  JOURNAL   Science 229 (4708), 69-73 (1985)
   PUBMED   2990040
REFERENCE   7  (sites)
  AUTHORS   Sodroski,J., Patarca,R., Rosen,C., Wong-Staal,F. and Haseltine,W.
  TITLE     Location of the trans-activating region on the genome of human
            T-cell lymphotropic virus type III
  JOURNAL   Science 229 (4708), 74-77 (1985)
   PUBMED   2990041
REFERENCE   8  (sites)
  AUTHORS   Rabson,A.B., Daugherty,D.F., Venkatesan,S., Boulukos,K.E.,
            Benn,S.I., Folks,T.M., Feorino,P. and Martin,M.A.
  TITLE     Transcription of novel open reading frames of AIDS retrovirus
            during infection of lymphocytes
  JOURNAL   Science 229 (4720), 1388-1390 (1985)
   PUBMED   2994220
REFERENCE   9  (sites)
  AUTHORS   Allan,J.S., Coligan,J.E., Lee,T.H., McLane,M.F., Kanki,P.J.,
            Groopman,J.E. and Essex,M.
  TITLE     A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS
            patients
  JOURNAL   Science 230 (4727), 810-813 (1985)
   PUBMED   2997921
REFERENCE   10  (sites)
  AUTHORS   Rosen,C.A., Sodroski,J.G., Goh,W.C., Dayton,A.I., Lippke,J. and
            Haseltine,W.A.
  TITLE     Post-transcriptional regulation accounts for the trans-activation
            of the human T-lymphotropic virus type III
  JOURNAL   Nature 319 (6054), 555-559 (1986)
   PUBMED   3003584
REFERENCE   11  (sites)
  AUTHORS   di Marzo Veronese,F., Copeland,T.D., DeVico,A.L., Rahman,R.,
            Oroszlan,S., Gallo,R.C. and Sarngadharan,M.G.
  TITLE     Characterization of highly immunogenic p66/p51 as the reverse
            transcriptase of HTLV-III/LAV
  JOURNAL   Science 231 (4743), 1289-1291 (1986)
   PUBMED   2418504
REFERENCE   12  (sites)
  AUTHORS   Kramer,R.A., Schaber,M.D., Skalka,A.M., Ganguly,K., Wong-Staal,F.
            and Reddy,E.P.
  TITLE     HTLV-III gag protein is processed in yeast cells by the virus
            pol-protease
  JOURNAL   Science 231 (4745), 1580-1584 (1986)
   PUBMED   2420008
REFERENCE   13  (sites)
  AUTHORS   Dayton,A.I., Sodroski,J.G., Rosen,C.A., Goh,W.C. and Haseltine,W.A.
  TITLE     The trans-activator gene of the human T cell lymphotropic virus
            type III is required for replication
  JOURNAL   Cell 44 (6), 941-947 (1986)
   PUBMED   2420471
REFERENCE   14  (sites)
  AUTHORS   Lee,T.H., Coligan,J.E., Allan,J.S., McLane,M.F., Groopman,J.E. and
            Essex,M.
  TITLE     A new HTLV-III/LAV protein encoded by a gene found in cytopathic
            retroviruses
  JOURNAL   Science 231 (4745), 1546-1549 (1986)
   PUBMED   3006243
REFERENCE   15  (sites)
  AUTHORS   Sodroski,J., Goh,W.C., Rosen,C., Tartar,A., Portetelle,D., Burny,A.
            and Haseltine,W.
  TITLE     Replicative and cytopathic potential of HTLV-III/LAV with sor gene
            deletions
  JOURNAL   Science 231 (4745), 1549-1553 (1986)
   PUBMED   3006244
REFERENCE   16  (sites)
  AUTHORS   Kan,N.C., Franchini,G., Wong-Staal,F., DuBois,G.C., Robey,W.G.,
            Lautenberger,J.A. and Papas,T.S.
  TITLE     Identification of HTLV-III/LAV sor gene product and detection of
            antibodies in human sera
  JOURNAL   Science 231 (4745), 1553-1555 (1986)
   PUBMED   3006245
REFERENCE   17  (sites)
  AUTHORS   Arya,S.K. and Gallo,R.C.
  TITLE     Three novel genes of human T-lymphotropic virus type III: immune
            reactivity of their products with sera from acquired immune
            deficiency syndrome patients
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (7), 2209-2213 (1986)
   PUBMED   3008154
REFERENCE   18  (sites)
  AUTHORS   Jones,K.A., Kadonaga,J.T., Luciw,P.A. and Tjian,R.
  TITLE     Activation of the AIDS retrovirus promoter by the cellular
            transcription factor, Sp1
  JOURNAL   Science 232 (4751), 755-759 (1986)
   PUBMED   3008338
REFERENCE   19  (sites)
  AUTHORS   Sodroski,J., Goh,W.C., Rosen,C., Dayton,A., Terwilliger,E. and
            Haseltine,W.
  TITLE     A second post-transcriptional trans-activator gene required for
            HTLV-III replication
  JOURNAL   Nature 321 (6068), 412-417 (1986)
   PUBMED   3012355
REFERENCE   20  (sites)
  AUTHORS   Starcich,B.R., Hahn,B.H., Shaw,G.M., McNeely,P.D., Modrow,S.,
            Wolf,H., Parks,E.S., Parks,W.P., Josephs,S.F., Gallo,R.C. and
            Wong-Staal,F.
  TITLE     Identification and characterization of conserved and variable
            regions in the envelope gene of HTLV-III/LAV, the retrovirus of
            AIDS
  JOURNAL   Cell 45 (5), 637-648 (1986)
   PUBMED   2423250
REFERENCE   21  (sites)
  AUTHORS   Willey,R.L., Rutledge,R.A., Dias,S., Folks,T., Theodore,T.,
            Buckler,C.E. and Martin,M.A.
  TITLE     Identification of conserved and divergent domains within the
            envelope gene of the acquired immunodeficiency syndrome retrovirus
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (14), 5038-5042 (1986)
   PUBMED   3014529
REFERENCE   22  (bases 8761 to 9060)
  AUTHORS   Fisher,A.G., Ratner,L., Mitsuya,H., Marselle,L.M., Harper,M.E.,
            Broder,S., Gallo,R.C. and Wong-Staal,F.
  TITLE     Infectious mutants of HTLV-III with changes in the 3' region and
            markedly reduced cytopathic effects
  JOURNAL   Science 233 (4764), 655-659 (1986)
   PUBMED   3014663
REFERENCE   23  (sites)
  AUTHORS   Feinberg,M.B., Jarrett,R.F., Aldovini,A., Gallo,R.C. and
            Wong-Staal,F.
  TITLE     HTLV-III expression and production involve complex regulation at
            the levels of splicing and translation of viral RNA
  JOURNAL   Cell 46 (6), 807-817 (1986)
   PUBMED   3638988
REFERENCE   24  (sites)
  AUTHORS   Lightfoote,M.M., Coligan,J.E., Folks,T.M., Fauci,A.S., Martin,M.A.
            and Venkatesan,S.
  TITLE     Structural characterization of reverse transcriptase and
            endonuclease polypeptides of the acquired immunodeficiency syndrome
            retrovirus
  JOURNAL   J. Virol. 60 (2), 771-775 (1986)
   PUBMED   2430111
REFERENCE   25  (sites)
  AUTHORS   Terwilliger,E., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A.
  TITLE     Effects of mutations within the 3' orf open reading frame region of
            human T-cell lymphotropic virus type III (HTLV-III/LAV) on
            replication and cytopathogenicity
  JOURNAL   J. Virol. 60 (2), 754-760 (1986)
   PUBMED   3490583
REFERENCE   26  (sites)
  AUTHORS   Wright,C.M., Felber,B.K., Paskalis,H. and Pavlakis,G.N.
  TITLE     Expression and characterization of the trans-activator of
            HTLV-III/LAV virus
  JOURNAL   Science 234 (4779), 988-992 (1986)
   PUBMED   3490693
REFERENCE   27  (sites)
  AUTHORS   Patarca,R., Heath,C., Goldenberg,G.J., Rosen,C.A., Sodroski,J.G.,
            Haseltine,W.A. and Hansen,U.M.
  TITLE     Transcription directed by the HIV long terminal repeat in vitro
  JOURNAL   AIDS Res. Hum. Retroviruses 3 (1), 41-55 (1987)
   PUBMED   3040054
REFERENCE   28  (bases 1 to 9635)
  AUTHORS   Ratner,L., Fisher,A., Jagodzinski,L.L., Mitsuya,H., Liou,R.S.,
            Gallo,R.C. and Wong-Staal,F.
  TITLE     Complete nucleotide sequences of functional clones of the AIDS
            virus
  JOURNAL   AIDS Res. Hum. Retroviruses 3 (1), 57-69 (1987)
   PUBMED   3040055
REFERENCE   29  (sites)
  AUTHORS   Wong-Staal,F., Chanda,P.K. and Ghrayeb,J.
  TITLE     Human immunodeficiency virus: the eighth gene
  JOURNAL   AIDS Res. Hum. Retroviruses 3 (1), 33-39 (1987)
   PUBMED   3476127
REFERENCE   30  (sites)
  AUTHORS   Modrow,S., Hahn,B.H., Shaw,G.M., Gallo,R.C., Wong-Staal,F. and
            Wolf,H.
  TITLE     Computer-assisted analysis of envelope protein sequences of seven
            human immunodeficiency virus isolates: prediction of antigenic
            epitopes in conserved and variable regions
  JOURNAL   J. Virol. 61 (2), 570-578 (1987)
   PUBMED   2433466
REFERENCE   31  (sites)
  AUTHORS   Goh,W.C., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A.
  TITLE     Expression of the art gene protein of human T-lymphotropic virus
            type III (HTLV-III/LAV) in bacteria
  JOURNAL   J. Virol. 61 (2), 633-637 (1987)
   PUBMED   3543401
REFERENCE   32  (sites)
  AUTHORS   Muesing,M.A., Smith,D.H. and Capon,D.J.
  TITLE     Regulation of mRNA accumulation by a human immunodeficiency virus
            trans-activator protein
  JOURNAL   Cell 48 (4), 691-701 (1987)
   PUBMED   3643816
REFERENCE   33  (sites)
  AUTHORS   Nabel,G. and Baltimore,D.
  TITLE     An inducible transcription factor activates expression of human
            immunodeficiency virus in T cells
  JOURNAL   Nature 326 (6114), 711-713 (1987)
   PUBMED   3031512
  REMARK    Erratum:[Nature 1990 Mar 8;344(6262):178]
REFERENCE   34  (sites)
  AUTHORS   Fisher,A.G., Ensoli,B., Ivanoff,L., Chamberlain,M., Petteway,S.,
            Ratner,L., Gallo,R.C. and Wong-Staal,F.
  TITLE     The sor gene of HIV-1 is required for efficient virus transmission
            in vitro
  JOURNAL   Science 237 (4817), 888-893 (1987)
   PUBMED   3497453
REFERENCE   35  (bases 6225 to 8795)
  AUTHORS   Reitz,M.S. Jr., Wilson,C., Naugle,C., Gallo,R.C. and
            Robert-Guroff,M.
  TITLE     Generation of a neutralization-resistant variant of HIV-1 is due to
            selection for a point mutation in the envelope gene
  JOURNAL   Cell 54 (1), 57-63 (1988)
   PUBMED   2838179
REFERENCE   36  (bases 790 to 2292)
  AUTHORS   Pal,R., Reitz,M.S. Jr., Tschachler,E., Gallo,R.C.,
            Sarngadharan,M.G. and Veronese,F.D.
  TITLE     Myristoylation of gag proteins of HIV-1 plays an important role in
            virus assembly
  JOURNAL   AIDS Res. Hum. Retroviruses 6 (6), 721-730 (1990)
   PUBMED   2194551
REFERENCE   37  (sites)
  AUTHORS   Ido,E., Han,H.P., Kezdy,F.J. and Tang,J.
  TITLE     Kinetic studies of human immunodeficiency virus type 1 protease and
            its active-site hydrogen bond mutant A28S
  JOURNAL   J. Biol. Chem. 266 (36), 24359-24366 (1991)
   PUBMED   1761538
COMMENT     On Mar 25, 1997 this sequence version replaced gi:327742.
            [6]  sites; tat mRNA and other transcript boundaries. [7]  sites;
            tat mRNA.
            [8]  sites; mRNA splice sites.
            [9]  sites; 27K antigen cds.
            [5]  sites; gp160 and gp120 coding sequences.
            [1]  sites; regulatory sequences in the LTR.
            [(in) Weiss,R., Teich,N., Varmus,H. and Coffin,J. (Eds.);RNA Tumor
            Viruses, Secon]  review; bases 1 to 9718.
            [15]  sites; trans-activator function and TAR sequence. [19]
            sites; pol coding sequence.
            [22]  sites; 23K sor gene product.
            [23]  sites; pol NH2-terminal region.
            [20]  sites; sor 23K protein.
            [21]  sites; sor 23K protein.
            [24]  sites; Sp1 binding sites in the promoter region. [17]  sites;
            acceptor and donor splice sites for tat and 27K. [10]  sites;
            deletion mutants in the tat gene.
            [18]  sites; env gene conserved/varable regions; separate entries.
            [16]  sites; trs cds boundaries.
            [12]  sites; trs cds boundaries.
            [11]  sites; env gene conserved/variable regions; separate entries.
            [26]  sites; tar or transactivator target.
            [13]  sites; 3' orf mutations.
            [14]  sites; pol p34 terminus.
            [31]  sites; promoter, TAR, tat-III mutants.
            [32]  sites; envelope protein epitopes.
            [33]  sites; trs/art protein.
            [34]  sites; inducible enhancer element.
            [27]  revises [30].
            [29]  sites; long terminal repeat.
            [28]  sites; R orf.
            [35]  sites; sor.
            Sequence for [25] kindly provided in computer-readable form by
            L.Ratner, 19-AUG-1986.
            The HXB2 sequence is being used as a reference genome for all the
            HIV entries because it has been derived from a demonstrably
            infectious clone.  Hence not all of the 'sites' references above
            were concerned with this isolate.
FEATURES             Qualifiers
     source          /organism="Human immunodeficiency virus 1"
                     /proviral
                     /mol_type="genomic RNA"
                     /isolate="HXB2"
                     /db_xref="taxon:11676"
                     /note="HTLV-III/LAV"
     protein         /note="tat protein"
     intron_pos      72:2 (1/1)
BEGIN
        1 MEPVDPRLEP WKHPGSQPKT ACTNCYCKKC CFHCQVCFIT KALGISYGRK KRRQRRRAHQ
       61 NSQTHQASLS KQPTSQPRGD PTGPKE
//