LOCUS AAB04947.2 2710 aa PRT HUM 02-APR-2004
DEFINITION Homo sapiens inositol 1,4,5-trisphosphate receptor type 1 protein.
ACCESSION L38019-1
PROTEIN_ID AAB04947.2
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8662)
AUTHORS Harnick,D.J., Jayaraman,T., Ma,Y., Mulieri,P., Go,L.O. and
Marks,A.R.
TITLE The human type 1 inositol 1,4,5-trisphosphate receptor from T
lymphocytes. Structure, localization, and tyrosine phosphorylation
JOURNAL J. Biol. Chem. 270 (6), 2833-2840 (1995)
PUBMED 7852357
REFERENCE 2 (bases 1 to 8662)
AUTHORS Marks,A.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-1994) Physiology, Columbia University, 630 W
168th Street, New York, NY 10032, USA
REFERENCE 3 (bases 1 to 8662)
AUTHORS Marks,A.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2004) Physiology, Columbia University, 630 W
168th Street, New York, NY 10032, USA
REMARK Sequence update by submitter
COMMENT On Apr 2, 2004 this sequence version replaced L38019.1.
FEATURES Qualifiers
source /db_xref="H-InvDB:HIT000193359"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3p"
/clone="HUM-IP3R1"
/cell_line="Jurkat"
/cell_type="T lymphocyte"
/tissue_type="T lymphocyte"
/dev_stage="adult"
protein /gene="ITPR1"
/db_xref="GDB:G00-127-552"
BEGIN
1 MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL
61 CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
121 IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
181 KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
241 RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
301 SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE
361 GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
421 SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
481 VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE
541 LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
601 NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT
661 NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA
721 KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA
781 SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF
841 VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH
901 VTTIFPISKM AKGEENKGSN VMRSIHGVGE LMTQVVLRGG GFLPMTPMAA APEGNVKQAE
961 PEKEDIMVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR EFDESNSQTS ETSSGNSSQE
1021 GPSNVPGALD FEHIEEQAEG IFGGSEENTP LDLDDHGGRT FLRVLLHLTM HDYPPLVSGA
1081 LQLLFRHFSQ RQEVLQAFKQ VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGQGP
1141 DETMDGASGE NEHKKTEEGN NKPQKHESTS SYNYRVVKEI LIRLSKLCVQ ESASVRKSRK
1201 QQQRLLRNMG AHAVVLELLQ IPYEKAEDTK MQEIMRLAHE FLQNFCAGNQ QNQALLHKHI
1261 NLFLNPGILE AVTMQHIFMN NFQLCSEINE RVVQHFVHCI ETHGRNVQYI KFLQTIVKAE
1321 GKFIKKCQDM VMAELVNSGE DVLVFYNDRA SFQTLIQMMR SERDRMDENS PLMYHIHLVE
1381 LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE
1441 IYTSNHMWKL FENFLVDICR ACNNTXDRKH ADSILEKYVT EIVMSIVTTF FSSPFSDQST
1501 TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN
1561 NLFLKSHSIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ
1621 AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR
1681 EMMTKDRGYG EKGEALRQVL VNRYYGNVRP SGRRESLTSF GNGPLSAGGP GKPGGGGGGS
1741 GSSSMSRGEM SLAEVQCHLD KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ
1801 HSFFCRLTED KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK
1861 AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QPGEGTQATA DKAKDDLEMS
1921 AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDCI CGSTTGGLGL
1981 LGLYINEKNV ALINQTLESL TEYCQGPCHE NQNCIATHES NGIDIITALI LNDINPLGKK
2041 RMDLVLELKN NASKLLLAIM ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE
2101 NGEDGAASPR NVGHNIYILA HQLARHNKEL QSMLKPGGQV DGDEALEFYA KHTAQIEIVR
2161 LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL FNEMNWQKKL
2221 RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFLYPLKGV RGGTLEPHWS GLLWTAMLIS
2281 LAIVIALPKP HGIRALIAST ILRLIFSVGL QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT
2341 RGYRAMVLDV EFLYHLLYLV ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRS
2401 IILTAVLALI LVYLFSIVGY LFFKDDFILE VDRLPNETAV PETGESLASE FLFSDVCRVE
2461 SGENCSSPAP REELVPAEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG DVLRKPSKEE
2521 PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK QKKEEILKTT CFICGLERXK
2581 FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV KDSTEYTGPE SYVAEMIKER NLDWFPRMRA
2641 MSLVSSDSEG EQNELRNLQE KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP
2701 HMNVNPQQPA
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