LOCUS       AAA61293.1               193 aa    PRT              HUM 14-JAN-1995
DEFINITION  Homo sapiens F8VWF protein.
ACCESSION   K03028-1
PROTEIN_ID  AAA61293.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 333 to 714)
  AUTHORS   Lynch,D.C.
  JOURNAL   Unpublished
REFERENCE   2  (bases 333 to 714)
  AUTHORS   Lynch,D.C., Zimmerman,T.S., Collins,C.J., Brown,M., Morin,M.J.,
            Ling,E.H. and Livingston,D.M.
  TITLE     Molecular cloning of cDNA for human von Willebrand factor:
            authentication by a new method
  JOURNAL   Cell 41 (1), 49-56 (1985)
   PUBMED   3873280
REFERENCE   3  (bases 333 to 598)
  AUTHORS   Verweij,C.L., de Vries,C.J., Distel,B., van Zonneveld,A.J., van
            Kessel,A.G., van Mourik,J.A. and Pannekoek,H.
  TITLE     Construction of cDNA coding for human von Willebrand factor using
            antibody probes for colony-screening and mapping of the chromosomal
            gene
  JOURNAL   Nucleic Acids Res. 13 (13), 4699-4717 (1985)
   PUBMED   3875078
REFERENCE   4  (bases 1 to 622)
  AUTHORS   Ginsburg,D., Handin,R.I., Bonthron,D.T., Donlon,T.A., Bruns,G.A.,
            Latt,S.A. and Orkin,S.H.
  TITLE     Human von Willebrand factor (vWF): isolation of complementary DNA
            (cDNA) clones and chromosomal localization
  JOURNAL   Science 228 (4706), 1401-1406 (1985)
   PUBMED   3874428
COMMENT     Original source text: Human umbilical cord endothelial cell, cDNA
            to mRNA, clones pDL34 [2], pvWF1210 [3], pVWd and pVWE6 [4].
            [1]  revises [2].
            Draft entry and clean copy sequence for [2],[1] kindly provided by
            D.Lynch, 17-SEP-1985; for [4] by D.Ginsberg, 09/17/85.  The von
            Willebrand factor is a large adhesive plasma glycoprotein, (the
            MRNA spans about 9 kb and the coding region 6 kb) that is
            instrumental in mediating the attachment of platelets to damaged
            areas of the circulatory system and serves as a carrier for factor
            VIIIC.  Pro-vWF is mainly produced in endothelial cells and
            undergoes a series of amino-terminal post-translational
            modifications, producing two subunits, which combine to form vFW
            multimers.  The vWF gene is large and appears to be interrupted by
            many introns.  The peptide starts with a possible signal peptide.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000191405"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="12pter-p12"
     protein         /gene="F8VWF"
                     /note="von Willebrand factor"
                     /db_xref="GDB:G00-119-125"
BEGIN
        1 KTTCNPCPLG YKEENNTGEC CGRCLPTACT IQLRGGQIMT LKRDETLQDG CDTHFCKVNE
       61 RGEYFWEKRV TGCPPFDEHK CLAEGGKIMK IPGTCCDTCE EPECNDITAR LQYVKVGSCK
      121 SEVEVDIHYC QGKCASKAMY SIDINDVQDQ CSCCSPTRTE PMQVALHCTN GSVVYHEVLN
      181 AMECKCSPRK CSK
//