LOCUS       AAA60553.1               241 aa    PRT              HUM 13-JAN-1995
DEFINITION  Homo sapiens c-sis/platelet-derived growth factor 2 protein.
ACCESSION   M12783-1
PROTEIN_ID  AAA60553.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Rao,C.D., Igarashi,H., Pech,M.W., Robbins,K.C. and Aaronson,S.A.
  TITLE     Oncogenic potential of the human platelet-derived growth factor
            transcriptional unit
  JOURNAL   Cold Spring Harb. Symp. Quant. Biol. 51 (Pt 2), 959-966 (1986)
   PUBMED   3472769
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Rao,C.D., Igarashi,H., Chiu,I.M., Robbins,K.C. and Aaronson,S.A.
  TITLE     Structure and sequence of the human c-sis/platelet-derived growth
            factor 2 (SIS/PDGF2) transcriptional unit
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (8), 2392-2396 (1986)
   PUBMED   3517869
COMMENT     Original source text: Human placenta, cDNA to mRNA, clone pSD1;
            DNA, clone pc-sis RH-9.
            Computer-readable sequence kindly provided by C.D.Rao, 31-JUL-1986.
            The first 70 and last 355 nucleotides in the sequence presented
            below were derived from DNA.  The normal human SIS/PDGF2 coding
            sequence has the capacity to efficiently transform cells responsive
            to its growth-promoting activity.  The SIS/PDGF2 mRNA has been
            detected in tumors such as glioblastomas and fibrosarcomas, whose
            normal counterparts possess PDGF receptors and are responsive to
            the growth-promoting action of the SIS/PDGF2 gene product.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000194179"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="22q12.3-q13.1"
                     /tissue_type="placenta"
     protein         /gene="PDGFB"
                     /db_xref="GDB:G00-120-709"
BEGIN
        1 MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL
       61 DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV
      121 WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC
      181 ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG
      241 A
//