LOCUS AAA60553.1 241 aa PRT HUM 13-JAN-1995 DEFINITION Homo sapiens c-sis/platelet-derived growth factor 2 protein. ACCESSION M12783-1 PROTEIN_ID AAA60553.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3798) AUTHORS Rao,C.D., Igarashi,H., Pech,M.W., Robbins,K.C. and Aaronson,S.A. TITLE Oncogenic potential of the human platelet-derived growth factor transcriptional unit JOURNAL Cold Spring Harb. Symp. Quant. Biol. 51 (Pt 2), 959-966 (1986) PUBMED 3472769 REFERENCE 2 (bases 1 to 3798) AUTHORS Rao,C.D., Igarashi,H., Chiu,I.M., Robbins,K.C. and Aaronson,S.A. TITLE Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (8), 2392-2396 (1986) PUBMED 3517869 COMMENT Original source text: Human placenta, cDNA to mRNA, clone pSD1; DNA, clone pc-sis RH-9. Computer-readable sequence kindly provided by C.D.Rao, 31-JUL-1986. The first 70 and last 355 nucleotides in the sequence presented below were derived from DNA. The normal human SIS/PDGF2 coding sequence has the capacity to efficiently transform cells responsive to its growth-promoting activity. The SIS/PDGF2 mRNA has been detected in tumors such as glioblastomas and fibrosarcomas, whose normal counterparts possess PDGF receptors and are responsive to the growth-promoting action of the SIS/PDGF2 gene product. FEATURES Qualifiers source /db_xref="H-InvDB:HIT000194179" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="22q12.3-q13.1" /tissue_type="placenta" protein /gene="PDGFB" /db_xref="GDB:G00-120-709" BEGIN 1 MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL 61 DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV 121 WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC 181 ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG 241 A //