LOCUS AAA60294.1 5032 aa PRT HUM 09-JAN-1995
DEFINITION Homo sapiens RYR1 protein.
ACCESSION J05200-1
PROTEIN_ID AAA60294.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 15346)
AUTHORS Zorzato,F., Fujii,J., Otsu,K., Phillips,M., Green,N.M., Lai,F.A.,
Meissner,G. and MacLennan,D.H.
TITLE Molecular cloning of cDNA encoding human and rabbit forms of the
Ca2+ release channel (ryanodine receptor) of skeletal muscle
sarcoplasmic reticulum
JOURNAL J. Biol. Chem. 265 (4), 2244-2256 (1990)
PUBMED 2298749
COMMENT Original source text: Human (adult) muscle, cDNA to mRNA, and DNA.
Draft entry and printed sequence for [1] kindly submitted by
D.H.MacLennan, 30-NOV-1989.
FEATURES Qualifiers
source /db_xref="H-InvDB:HIT000191318"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.1"
protein /gene="RYR1"
/note="ryanodine receptor"
/db_xref="GDB:G00-120-359"
BEGIN
1 MGDAEGEDEV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
61 LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSRMYLSCL
121 TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
181 LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
241 RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGQYL ALTEDQGLVV
301 VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
361 PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF
421 SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE
481 GMLSMVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS
541 TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
601 VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG RAEGTTQYSK
661 WYFEVMVDEV TPFLTAQATH LRVGWALTEG YTPYPGAGEG WGGNGVGDDL YSYGFDGLHL
721 WTGHVARPVT SPGQHLLAPE DVISCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV
781 SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG
841 PSRCLSHTDF VPCPVDTVQI VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPVRDDNK
901 RLHPCLVDFH SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEDNLK KTKLPKTYMM
961 SNGYKPAPLD LSHVRLTPAQ TTLVDRLAEN GHNVWARDRV GQGWSYSAVQ DIPARRNPRL
1021 VPYRLLDEAT KRSNRDSLCQ AVRTLLGYGY NIEPPDQEPS QVENQSRCDR VRIFRAEKSY
1081 TVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR WHLGSEPFGR
1141 PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDGFLPV CSLGPGQVGH
1201 LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKG LPQFEPVPLE HPHYEVSRVD
1261 GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFHQHF RCTAGATPLA PPGLQPPAED
1321 EARAAEPDPD YENLRRSAGG WSEAENGKEG TAKEGAPGGT PQAGRGAPAR AENEKDATTE
1381 KNKKRGFLFK AKKVAMMTQP PATPTLPRLP HDVVPADNRD DPEIILNTTT YYYSVRVFAG
1441 QEPSCVWAGW VTPDYHQHDM SFDLSKVRVV TVTMGDEQGN VHSSLKCSNC YMVWGGDFVS
1501 PGQQGRISHT DLVIGCLVDL ATGLMTFTAN GKESNTFFQV EPNTKLFPAV FVLPTHQNVI
1561 QFELGKQKNI MPLSAAMFQS ERKNPAPQCP PRLEMQMLMP VSWSRMPNHF LQVETRRAGE
1621 RLGWAVQCQE PLTMMALHIP EENRCMDILE LSERLDLQRF HSHTLRLYRA VCALGNNRVA
1681 HALCSHVDQA QLLHALEDAH LPGPLRAGYY DLLISIHLES ACRSRRSMLS EYIVPLTPET
1741 RAITLFPPGR STENGHPRHG LPGVGVTTSL RPPHHFSPPC FVAALPAAGA AEAPARLSPA
1801 IPLEALRDKA LRMLGEAVRD GGQHARDPVG ASVEFQFVPV LKLVSTLLVM GIFGDEDVKQ
1861 ILKMIEPEVF TEEEEEEDEE EEGEEEDEEE KEEDEEETAQ EKEDEEKEEE EAAEGEKEEG
1921 LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQA NQRSRYGLLI
1981 KAFSMTAAET ARRTREFRSP PQEQINMLLQ FKDGTDEEDC PLPEEIRQDL LDFHQDLLAH
2041 CGIQLDGEEE EPEEETTLGS RLMSLLEKVR LVKKKEEKPE EERSAEESKP RSLQELVSHM
2101 VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISPSSVED TMSLLECLGQ
2161 IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
2221 EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI
2281 DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLVAKGYPDI GWKPCGGERY LDFLRFAVFV
2341 NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGIRRDR
2401 RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV
2461 PLEDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS MVLFLDRVYG IENQDFLLHV
2521 LDVGFLPDMR AAASLDTATF STTEMALAVN RYLCLAVLPL ITKCAPLFAG TEHRAIMVDS
2581 MLHTVYRLSR GRSLTKAQRD VIEDCLMSLC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL
2641 KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DPELYRMAMP
2701 CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE TLNVIIPEKL DSFINKFAEY
2761 THEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD KEIYRWPIKE SLKAMIAWEW
2821 TIEKAREGEE EKTEKKKTAK ISQSAQTYDP REGYNPQPPD LSAVTLSREL QAMAEQLAEN
2881 YHNTWGRKKK QELEAKGGGT HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRGL
2941 KDMELDSSSI EKRFAFGFLQ QLLRWMDISQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI
3001 LLPLINQYFT NHCLYFLSTP AKVLGSGGHA SNKEKEMITS LFCKLAALVR HRVSLFGTDA
3061 PAVVNCLHIL ARSLDARTVM KSGPEIVKAG LRSFFESASE DIEKMVENLR LGKVSQARTQ
3121 VKGVGQNLTY TTVALLPVLT TLFQHIAQHQ FGDDVILDDV QVSCYRTLCS IYSLGTTKNT
3181 YVEKLRPALG ECLARLAAAM PVAFLEPQLN EYNACSVYTT KSPRERAILG LPNSVEEMCP
3241 DIPVLERLMA DIGGLAESGA RYTEMPHVIE ITLPMLCSYL PRWWERGPEA PPSALPAGAP
3301 PPCTAVTSDH LNSLLGNILR IIVNNLGIDE ASWMKRLAVF AQPIVSRARP ELLQSHFIPT
3361 IGRLRKRAGK VVSEEEQLAL EAKAEAQEGE LLVRDEFSVL CRDLYALYPL LIRYVDNNRA
3421 QWLTEPNPSA EELFRMVGEI FIYWSKSHNF KREEQNFVVQ NEINNMSFLT ADNKSKMAKS
3481 GGSDQERTKK KRRGDRYSVQ TSLIVATLKK MLPIGLNMCA PTDQDLITLA KTRYALKDTD
3541 EEVREFLHNN LHLQGKVEGS PSLRWQMALY RGVPGREEDA DDPEKIVRRV QEVSAVLYYL
3601 DQTEHPYKSK KAVWHKLLSK QRRRAVVACF RMTPLYNLPT HRACNMFLES YKAAWILTED
3661 HSFEDRMIDD LSKAGEQEEE EEEVEEKKPD PLHQLVLHFS RTALTEKSKL DEDYLYMAYA
3721 DIMAKSCHLE EGGENGEAEE EVEVSFEEKQ MEKQRLLYQQ ARLHTRGAAE MVLQMISACK
3781 GETGAMVSST LKLGISILNG GNAEVQQKML DYLKDKKEVG FFQSIQALMQ TCSVLDLNAF
3841 ERQNKAEGLG MVNEDGTVIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN DFQNYLRTQT
3901 GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG KRNFSKAMSV AKQVFNSLTE
3961 YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA HMMMKLAQDS SQIELLKELL DLQKDMVVML
4021 LSLLEGNVVN GMIARQMVDM LVESSSNVEM ILKFFDMFLK LKDIVGSEAF QDYVTDPRGL
4081 ISKKDFQKAM DSQKQFSGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR DIGFNVAVLL
4141 TNLSEHVPHD PRLHNFLELA ESILEYFRPY LGRIEIMGAS RRIERIYFEI SETNRAQWEM
4201 PQVKESKRQF IFDVVNEGGE AEKMELFVSF CEDTIFEMQI AAQISEPEGE PETDEDEGAG
4261 AAEAGAEGAE EGAAGLEGTA ATAAAGATAR VVAAAGRALR GLSYRSLRRR VRRLRRLTAR
4321 EAATAVAALL WAAVTRAGAA GAGAAAGALG LLWGSLFGGG LVEGAKKVTV TELLAGMPDP
4381 TSDEVHGEQP AGPGGDADGE GASEGAGDAA EGAGDEEEAV HEAGPGGADG AVAVTDGGPF
4441 RPEGAGGLGD MGDTTPAEPP TPEGSPILKR KLGVDGVEEE LPPEPEPEPE PELEPEKADA
4501 ENGEKEEVPE PTPEPPKKQA PPSPPPKKEE AGGEFWGELE VQRVKFLNYL SRNFYTLRFL
4561 ALFLAFAINF ILLFYKVSDS PPGEDDMEGS AAGDVSGAGS GGSSGWGLGA GEEAEGDEDE
4621 NMVYYFLEES TGYMEPALRC LSLLHTLVAF LCIIGYNCLK VPLVIFKREK ELARKLEFDG
4681 LYITEQPEDD DVKGQWDRLV LNTPSFPSNY WDKFVKRKVL DKHGDIYGRE RIAELLGMDL
4741 ATLEITAHNE RKPNPPPGLL TWLMSIDVKY QIWKFGVIFT DNSFLYLGWY MVMSLLGHYN
4801 NFFFAAHLLD IAMGVKTLRT ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA FNFFRKFYNK
4861 SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI
4921 VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGS DYFDTTPHGF ETHTLEEHNL
4981 ANYMFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LS
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