LOCUS       AAA59575.1              1280 aa    PRT              HUM 03-DEC-1999
DEFINITION  Homo sapiens PGY1 protein.
ACCESSION   M14758-1
PROTEIN_ID  AAA59575.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4646)
  AUTHORS   Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I.,
            Gottesman,M.M. and Roninson,I.B.
  TITLE     Internal duplication and homology with bacterial transport proteins
            in the mdr1 (P-glycoprotein) gene from multidrug-resistant human
            cells
  JOURNAL   Cell 47 (3), 381-389 (1986)
   PUBMED   2876781
REFERENCE   2  (sites)
  AUTHORS   Ueda,K., Clark,D.P., Chen,C.J., Roninson,I.B., Gottesman,M.M. and
            Pastan,I.
  TITLE     The human multidrug resistance (mdr1) gene. cDNA cloning and
            transcription initiation
  JOURNAL   J. Biol. Chem. 262 (2), 505-508 (1987)
   PUBMED   3027054
REFERENCE   3  (bases 971 to 985; 3095 to 3109)
  AUTHORS   Kioka,N., Tsubota,J., Kakehi,Y., Komano,T., Gottesman,M.M.,
            Pastan,I. and Ueda,K.
  TITLE     P-glycoprotein gene (MDR1) cDNA from human adrenal: normal
            P-glycoprotein carries Gly185 with an altered pattern of multidrug
            resistance
  JOURNAL   Biochem. Biophys. Res. Commun. 162 (1), 224-231 (1989)
   PUBMED   2568832
COMMENT     Original source text: Human drug-resistant cell line KB-C2.5 cDNA
            to mRNA, clones lambda-HDR[10, 5, 104].
            [2]  sites.
            Draft entry and computer-readable sequence [1] kindly submitted by
            I.B.Roninson, 13-AUG-1987.
            The sequence shown is of a cDNA clone initiating at a minor
            upstream transcription initiation site and containing the major
            site of transcription initiation.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000194362"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="7q21"
     protein         /gene="PGY1"
                     /note="P-glycoprotein"
BEGIN
        1 MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII
       61 HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG
      121 IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS
      181 KINEVIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT
      241 DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
      301 AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG
      361 AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG
      421 QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF
      481 ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA
      541 IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
      601 FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS
      661 SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII
      721 NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA
      781 GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI
      841 ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGAGKIATEA
      901 IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG
      961 AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS
     1021 YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV
     1081 QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV
     1141 SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
     1201 EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL
     1261 LAQKGIYFSM VSVQAGTKRQ
//