LOCUS AAA51884.1 375 aa PRT HUM 01-NOV-1994 DEFINITION Homo sapiens ADH2 protein. ACCESSION M24317-1 PROTEIN_ID AAA51884.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1618) AUTHORS Ikuta,T., Fujiyoshi,T., Kurachi,K. and Yoshida,A. TITLE Molecular cloning of a full-length cDNA for human alcohol dehydrogenase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (9), 2703-2707 (1985) PUBMED 2986130 REFERENCE 2 (bases 733 to 738) AUTHORS Ikuta,T., Fujiyoshi,T., Kurachi,K. and Yoshida,A. TITLE Correction: Molecular cloning of a full-length cDNA for human alcohol dehydrogenase JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 5578-5578 (1985) REFERENCE 3 (bases 164 to 183; 1132 to 1148) AUTHORS Xu,Y.L., Carr,L.G., Bosron,W.F., Li,T.K. and Edenberg,H.J. TITLE Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification JOURNAL Genomics 2 (3), 209-214 (1988) PUBMED 3397059 COMMENT Original source text: Human liver, cDNA to mRNA, (library of Woo) clone lambda-ADH14. [2] revises [1]. Reprint of [1] kindly provided by A.Yoshida, 15-SEP-1985. Draft entry and clean copy sequence for [2] kindly provided by G.Duester, 31-MAR-1986. ADH is encoded by at least five genes that fall into three classes. Class I, which evolved as a multigene family, contains a large group of isoenzymes possessing various combinations of alpha, beta, and gamma subunits, coded for by three genes designated ADH1, ADH2, and ADH3, respectively. Class II contains the pi isoenzyme and class III contains the chi isoenzyme. The majority of Orientals have the 'atypical' 2-ADH-2 gene, producing an atypical beta-2 subunit instead of the beta-1 subunit, which is predominant in Caucasians. The other human class I ADH1 beta subunit sequences are found under accession D00137 X03350 M24308-M24316 M21692. FEATURES Qualifiers source /db_xref="H-InvDB:HIT000194923" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="4q21-q23" protein /gene="ADH2" /note="alcohol dehydrogenase beta subunit" /db_xref="GDB:G00-119-651" BEGIN 1 MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD DHVVSGNLVT 61 PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRVCKNPESN YCLKNDLGNP 121 RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 181 YGSAVNVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKK AKAKELGATE 241 CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 301 NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV LPFEKINEGF 361 DLLHSGKSIR TVLTF //