LOCUS       AAA37523.1               187 aa    PRT              ROD 24-SEP-2001
DEFINITION  Mus musculus dihydrofolate reductase protein.
ACCESSION   L26316-1
PROTEIN_ID  AAA37523.1
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 91 to 217; 228 to 240; 318 to 343; 346 to 517)
  AUTHORS   Nunberg,J.H., Kaufman,R.J., Chang,A.C., Cohen,S.N. and Schimke,R.T.
  TITLE     Structure and genomic organization of the mouse dihydrofolate
            reductase gene
  JOURNAL   Cell 19 (2), 355-364 (1980)
   PUBMED   6244105
REFERENCE   2  (bases 28 to 986)
  AUTHORS   Setzer,D.R., McGrogan,M. and Schimke,R.T.
  TITLE     Nucleotide sequence surrounding multiple polyadenylation sites in
            the mouse dihydrofolate reductase gene
  JOURNAL   J. Biol. Chem. 257 (9), 5143-5147 (1982)
   PUBMED   6121807
REFERENCE   3  (bases 1 to 670)
  AUTHORS   Crouse,G.F., Simonsen,C.C., McEwan,R.N. and Schimke,R.T.
  TITLE     Structure of amplified normal and variant dihydrofolate reductase
            genes in mouse sarcoma S180 cells
  JOURNAL   J. Biol. Chem. 257 (13), 7887-7897 (1982)
   PUBMED   6282858
REFERENCE   4  (bases 71 to 528)
  AUTHORS   Simonsen,C.C. and Levinson,A.D.
  TITLE     Isolation and expression of an altered mouse dihydrofolate
            reductase cDNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 80 (9), 2495-2499 (1983)
   PUBMED   6573667
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Schilling,L.J. and Farnham,P.J.
  TITLE     Transcriptional regulation of the dihydrofolate reductase/rep-3
            locus
  JOURNAL   Crit. Rev. Eukaryot. Gene Expr. 4 (1), 19-53 (1994)
   PUBMED   7987046
FEATURES             Qualifiers
     source          /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /cell_line="sarcoma cell line s180"
     protein         /gene="dhfr"
BEGIN
        1 MVRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS
       61 IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS
      121 VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF
      181 EVYEKKD
//