LOCUS       AAA17374.1               756 aa    PRT              HUM 31-MAR-1994
DEFINITION  Homo sapiens hmlh1 protein.
ACCESSION   U07418-1
PROTEIN_ID  AAA17374.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Papadopoulos,N., Nicolaides,N.C., Wei,Y.F., Ruben,S.M.,
            Carter,K.C., Rosen,C.A., Haseltine,W.H., Fleischmann,R.D.,
            Fraser,C.M., Adams,M.D., Venter,J.C., Hamilton,S.R., Petersen,G.M.,
            Watson,P., Lynch,H.T., Peltomaki,P., Mecklin,J.P., Chapelle,A.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mutation of a mutL homolog in hereditary colon cancer
  JOURNAL   Science 263 (5153), 1625-1629 (1994)
   PUBMED   8128251
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Wei,Y.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAR-1994) Ying-Fei Wei, Molecular Biology, Human
            Genome Sciences, Inc., 9620 Medical Center Drive, Rockville, MD
            20850, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000217662"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="p21"
                     /tissue_type="gall bladder"
                     /dev_stage="adult"
     protein         /gene="hmlh1"
                     /function="DNA mismatch repair"
                     /note="human homolog of E. coli mutL gene product,
                     Swiss-Prot Accession Number P23367"
BEGIN
        1 MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVI VKEGGLKLIQ
       61 IQDNGTGIRK EDLDIVCERF TTSKLQSFED LASISTYGFR GEALASISHV AHVTITTKTA
      121 DGKCAYRASY SDGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKILEVV
      181 GRYSVHNAGI SFSVKKQGET VADVRTLPNA STVDNIRSVF GNAVSRELIE IGCEDKTLAF
      241 KMNGYISNAN YSVKKCIFLL FINHRLVEST SLRKAIETVY AAYLPKNTHP FLYLSLEISP
      301 QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEMV
      361 KSTTSLTSSS TSGSSDKVYA HQMVRTDSRE QKLDAFLQPL SKPLSSQPQA IVTEDKTDIS
      421 SGRARQQDEE MLELPAPAEV AAKNQSLEGD TTKGTSEMSE KRGPTSSNPR KRHREDSDVE
      481 MVEDDSRKEM TAACTPRRRI INLTSVLSLQ EEINEQGHEV LREMLHNHSF VGCVNPQWAL
      541 AQHQTKLYLL NTTKLSEELF YQILIYDFAN FGVLRLSEPA PLFDLAMLAL DSPESGWTEE
      601 DGPKEGLAEY IVEFLKKKAE MLADYFSLEI DEEGNLIGLP LLIDNYVPPL EGLPIFILRL
      661 ATEVNWDEEK ECFESLSKEC AMFYSIRKQY ISEESTLSGQ QSEVPGSIPN SWKWTVEHIV
      721 YKALRSHILP PKHFTEDGNI LQLANLPDLY KVFERC
//