LOCUS AAA17374.1 756 aa PRT HUM 31-MAR-1994 DEFINITION Homo sapiens hmlh1 protein. ACCESSION U07418-1 PROTEIN_ID AAA17374.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2503) AUTHORS Papadopoulos,N., Nicolaides,N.C., Wei,Y.F., Ruben,S.M., Carter,K.C., Rosen,C.A., Haseltine,W.H., Fleischmann,R.D., Fraser,C.M., Adams,M.D., Venter,J.C., Hamilton,S.R., Petersen,G.M., Watson,P., Lynch,H.T., Peltomaki,P., Mecklin,J.P., Chapelle,A.D., Kinzler,K.W. and Vogelstein,B. TITLE Mutation of a mutL homolog in hereditary colon cancer JOURNAL Science 263 (5153), 1625-1629 (1994) PUBMED 8128251 REFERENCE 2 (bases 1 to 2503) AUTHORS Wei,Y.F. TITLE Direct Submission JOURNAL Submitted (04-MAR-1994) Ying-Fei Wei, Molecular Biology, Human Genome Sciences, Inc., 9620 Medical Center Drive, Rockville, MD 20850, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000217662" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="p21" /tissue_type="gall bladder" /dev_stage="adult" protein /gene="hmlh1" /function="DNA mismatch repair" /note="human homolog of E. coli mutL gene product, Swiss-Prot Accession Number P23367" BEGIN 1 MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVI VKEGGLKLIQ 61 IQDNGTGIRK EDLDIVCERF TTSKLQSFED LASISTYGFR GEALASISHV AHVTITTKTA 121 DGKCAYRASY SDGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKILEVV 181 GRYSVHNAGI SFSVKKQGET VADVRTLPNA STVDNIRSVF GNAVSRELIE IGCEDKTLAF 241 KMNGYISNAN YSVKKCIFLL FINHRLVEST SLRKAIETVY AAYLPKNTHP FLYLSLEISP 301 QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEMV 361 KSTTSLTSSS TSGSSDKVYA HQMVRTDSRE QKLDAFLQPL SKPLSSQPQA IVTEDKTDIS 421 SGRARQQDEE MLELPAPAEV AAKNQSLEGD TTKGTSEMSE KRGPTSSNPR KRHREDSDVE 481 MVEDDSRKEM TAACTPRRRI INLTSVLSLQ EEINEQGHEV LREMLHNHSF VGCVNPQWAL 541 AQHQTKLYLL NTTKLSEELF YQILIYDFAN FGVLRLSEPA PLFDLAMLAL DSPESGWTEE 601 DGPKEGLAEY IVEFLKKKAE MLADYFSLEI DEEGNLIGLP LLIDNYVPPL EGLPIFILRL 661 ATEVNWDEEK ECFESLSKEC AMFYSIRKQY ISEESTLSGQ QSEVPGSIPN SWKWTVEHIV 721 YKALRSHILP PKHFTEDGNI LQLANLPDLY KVFERC //