LOCUS       SIU02549.1               289 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccd2. esx-2 type vii secretion system
            protein. probable transmembrane protein. protein.
ACCESSION   LT708304-3963
PROTEIN_ID  SIU02549.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccd2"
                     /locus_tag="BQ2027_MB3917C"
                     /note="Mb3917c, -, len: 289 aa. Equivalent to 3' end of
                     Rv3887c, len: 509 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.7% identity in 288 aa overlap). Probable
                     conserved transmembrane protein (has hydrophilic stretch
                     from ~1-130 then very hydrophobic domain), similar to
                     other membrane proteins and with weak similarity to known
                     transporters, e.g. Q9CBV2|ML1539 PROBABLE MEMBRANE PROTEIN
                     from Mycobacterium leprae (503 aa), FASTA scores: opt:
                     395, E(): 2.3e-16, (28.0% identity in 496 aa overlap);
                     Q9CD35|ML2529 CONSERVED MEMBRANE PROTEIN from
                     Mycobacterium leprae (485 aa), FASTA scores: opt: 221,
                     E(): 6.6e-06, (24.6% identity in 423 aa overlap);
                     Q9ADP8|2SC10A7.11 PUTATIVE INTEGRAL MEMBRANE PROTEIN from
                     Streptomyces coelicolor (430 aa), FASTA scores: opt: 171,
                     E(): 0.0062, (26.55% identity in 358 aa overlap);
                     CAC44275|SCBAC17F8.03 PUTATIVE DRUG EFFLUX PROTEIN from
                     Streptomyces coelicolor (416 aa), FASTA scores: opt: 160,
                     E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also
                     similar to others from Mycobacterium tuberculosis e.g.
                     O53944|Rv1795|MTV049.17 PUTATIVE MEMBRANE PROTEIN (503
                     aa), FASTA scores: opt: 360, E(): 2.9e-14, (26.65%
                     identity in 514 aa overlap); etc. Equivalent to AAK48369
                     from Mycobacterium tuberculosis strain CDC1551 (469 aa)
                     but longer 40 aa. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium bovis, a deletion of 2406 bp leads to the
                     loss of the NH2 part of Rv3887c, the entire Rv3888c and
                     the COOH part of Rv3889c compared to Mycobacterium
                     tuberculosis strain H37Rv. Protein product from Mb3917c
                     detected using SWATH mass spectrometry. Mb3917c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5J4"
                     /db_xref="InterPro:IPR006707"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5J4"
BEGIN
        1 MAAHALIGLV VVVLGAITIG VATRKRWQTA VVTAVVTVCG ILAAVAAVRM FRPVSMQVLA
       61 ICVLVGLLVL IRMTPTVALW VARVRPPHFG SITGRDLFAR RAGMPVDTVA PVSEADADDE
      121 DNELTGITAR GTAIAASARL VNAVQVGMCV GVSLVLPAAV WGVLTPRQPW AWLALLVAGL
      181 TVGLFITQGR GFAAKYQAVA LVCGASAAVC AGVLKYALDT PKGVQTGLLW PAIFVAAFAA
      241 LGLAVALVVP ATRFRPIIRL TVEWLEVLAM IALLPAAAAL GGLFAWLRH
//