LOCUS       SIU02547.1               537 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component ecce2. esx-2 type vii secretion system
            protein. possible membrane protein. protein.
ACCESSION   LT708304-3961
PROTEIN_ID  SIU02547.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ecce2"
                     /locus_tag="BQ2027_MB3915C"
                     /note="Mb3915c, -, len: 537 aa. Equivalent to Rv3885c,
                     len: 537 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 537 aa overlap). Possible conserved
                     membrane protein (has hydrophobic stretch near
                     N-terminus), showing some similarity with
                     O05462|Rv3882c|MTV027.17c|MTCY15F10.30 POSSIBLE MEMBRANE
                     PROTEIN from Mycobacterium tuberculosis (462 aa) FASTA
                     scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa
                     overlap); and O33077|ML0042|MLCB628.05 PUTATIVE MEMBRANE
                     PROTEIN from Mycobacterium leprae (467 aa), FASTA scores:
                     opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa
                     overlap). Equivalent to AAK48368 from Mycobacterium
                     tuberculosis strain CDC1551 (422 aa) but longer 115 aa.
                     Protein product from Mb3915c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3915c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y5J7"
                     /db_xref="InterPro:IPR021368"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5J7"
BEGIN
        1 MTSKLTGFSP RSARRVAGVW TVFVLASAGW ALGGQLGAVM AVVVGVALVF VQWWGQPAWS
       61 WAVLGLRGRR PVKWNDPITL ANNRSGGGVR VQDGVAVVAV QLLGRAHRAT TVTGSVTVES
      121 DNVIDVVELA PLPRHPLDLE LDSISVVTFG SRTGTVGDYP RVYDAEIGTP PYAGRRETWL
      181 IMRLPVIGNT QALRWRTSVG AAAISVAQRV ASSLRCQGLR AKLATATDLA ELDRRLGSDA
      241 VAGSAQRWKA IRGEAGWMTT YAYPAEAISS RVLSQAWTLR ADEVIQNVTV YPDATCTATI
      301 TVRTPTPAPT PPSVILRRLN GEQAAAAAAN MCGPRPHLRG QRRCPLPAQL VTEIGPSGVL
      361 IGKLSNGDRL MIPVTDAGEL SRVFVAADDT IAKRIVIRVV GAGERVCVHT RDQERWASVR
      421 MPQLSIVGTP RPAPRTTVGV VEYVRRRKNG DDGKSEGSGV DVAISPTPRP ASVITIARPG
      481 TSLSESDRHG FEVTIEQIDR ATVKVGAAGQ NWLVEMEMFR AENRYVSLEP VTMSIGR
//