LOCUS       SIU02536.1               100 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 10
            kda culture filtrate antigen esxb (lhp) (cfp10) protein.
ACCESSION   LT708304-3950
PROTEIN_ID  SIU02536.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="esxB"
                     /locus_tag="BQ2027_MB3904"
                     /standard_name="lhp; cfp10"
                     /note="Mb3904, esxB, len: 100 aa. Equivalent to Rv3874,
                     len: 100 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 100 aa overlap). esxB (alternate gene
                     name: cfp10), 10 KDA culture filtrate antigen (see
                     citations below, especially first), highly similar to
                     O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA CULTURE
                     FILTRATE ANTIGEN CFP10 HOMOLOG from Mycobacterium leprae
                     (99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4%
                     identity in 99 aa overlap). Also similar to
                     O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 PUTATIVE
                     ESAT-6 LIKE PROTEIN 13 from Mycobacterium tuberculosis
                     (103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1%
                     identity in 91 aa overlap); and shows some similarity with
                     other proteins from Mycobacterium tuberculosis. Contains
                     probable coiled-coil from aa 49-93. BELONGS TO THE ESAT6
                     FAMILY. Protein product from Mb3904 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb3904
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P0A567"
                     /db_xref="InterPro:IPR010310"
                     /db_xref="InterPro:IPR036689"
                     /db_xref="UniProtKB/Swiss-Prot:P0A567"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MAEMKTDAAT LAQEAGNFER ISGDLKTQID QVESTAGSLQ GQWRGAAGTA AQAAVVRFQE
       61 AANKQKQELD EISTNIRQAG VQYSRADEEQ QQALSSQMGF
//