LOCUS       SIU02367.1               329 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            dna polymerase iii (epsilon subunit) dnaq protein.
ACCESSION   LT708304-3781
PROTEIN_ID  SIU02367.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dnaQ"
                     /locus_tag="BQ2027_MB3738C"
                     /note="Mb3738c, dnaQ, len: 329 aa. Equivalent to Rv3711c,
                     len: 329 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.1% identity in 329 aa overlap). Probable dnaQ, DNA
                     polymerase III, epsilon subunit (EC 2.7.7.7), similar to
                     many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328
                     aa), FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity
                     in 315 aa overlap); Q9JYS6|NMB1451 from Neisseria
                     meningitidis (serogroup B) (and Q9JTR5|MA1665 from
                     serogroup A) (470 aa), FASTA scores: opt: 247, E():
                     2.6e-08, (33.15% identity in 172 aa overlap);
                     O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215
                     aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65%
                     identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215
                     from Escherichia coli strain K12 (243 aa), FASTA scores:
                     opt: 208, E(): 4.5e-06, (28.4% identity in 169 aa
                     overlap); etc. Also similar to
                     Q10384|YL91_MYCTU|Rv2191|MTCY190.02 from Mycobacterium
                     tuberculosis (645 aa), FASTA scores: opt: 260, E(): 5e-09,
                     (28.55% identity in 301 aa overlap). Mb3738c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4Y4"
                     /db_xref="InterPro:IPR006054"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR013520"
                     /db_xref="InterPro:IPR036397"
                     /db_xref="InterPro:IPR036420"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Y4"
BEGIN
        1 MSHTWGRPAS HQDRGWAVID VETSGFRPGQ ARIISLAVLG LDAAGRLEQS VVSLLNPKVD
       61 PGPTHVHGLT AAMLDDQPQF ADIAGEVVDV LRGRTLVAHN VAFDYAFLAA EAEIAEAELP
      121 VDFVMCTVEL ARRLQLGVDN LRLETLAAHW GVPQQRPHDA FDDARVLTGI LAAALESARE
      181 LDVWLPVHPV TRRRWPNGRV THDELRPLKA LAARMACPYL NPGRYVQGRP LVQGMRVGLA
      241 AEVKRTHEEL VERILHAGLA YSDVVDRDTS LVVCNATAPE HGKGYHALQL GVPVMPEARF
      301 MECIGAVVGG ASVEDFTDVA PVEKQLALF
//