LOCUS       SIU02301.1               771 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            helicase protein.
ACCESSION   LT708304-3715
PROTEIN_ID  SIU02301.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3673"
                     /note="Mb3673, -, len: 771 aa. Equivalent to Rv3649, len:
                     771 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.9% identity in 771 aa overlap). Probable helicase (EC
                     3.6.-.-), similar to many (known or hypothetical)
                     ATP-dependent helicases e.g. Q9X915|SCH5.13 PUTATIVE
                     HELICASE from Streptomyces coelicolor (815 aa) FASTA
                     scores: opt: 2550, E(): 9.6e-139, (52.45% identity in 774
                     aa overlap); Q05549|YDR291W|D9819.1 PROTEIN SIMILAR TO
                     SEVERAL DNA HELICASES from Saccharomyces cerevisiae
                     (Baker's yeast) (1077 aa), FASTA scores: opt: 1161, E():
                     5.9e-59, (31.05% identity in 780 aa overlap);
                     P50830|YPRA_BACSU HYPOTHETICAL HELICASE from Bacillus
                     subtilis (749 aa), FASTA scores: opt: 1154, E(): 1.1e-58,
                     (34.05% identity in 734 aa overlap); Q9KC10|BH1764
                     ATP-DEPENDENT RNA HELICASE from Bacillus halodurans (764
                     aa), FASTA scores: opt: 1122, E(): 8e-57, (32.3% identity
                     in 759 aa overlap); etc. SEEMS SIMILAR TO DEAD/DEAH BOX
                     HELICASE FAMILY, AND TO HELICASE C-TERMINAL DOMAIN."
                     /db_xref="GOA:A0A1R3Y4Q3"
                     /db_xref="InterPro:IPR001650"
                     /db_xref="InterPro:IPR011545"
                     /db_xref="InterPro:IPR014001"
                     /db_xref="InterPro:IPR018973"
                     /db_xref="InterPro:IPR022307"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Q3"
BEGIN
        1 MASFGSHLLA AAVAGTPPGE RPLRHVAELP PQAGRPRGWP EWAEPDVVDA FADRGISSPW
       61 SHQAEAAELA YAGRHVVIGT GPASGKSLAY QLPVLNALAT DSRARALYLS PTKALGHDQL
      121 RAAHALAAAV PRLADVAPTA YDGDSPDEVR RFARERSRWL FSNPEMTHLS VLRNHARWAV
      181 LLRNLRFVIV DECHYYRGVF GSNVAMVLRR LLRLCARYSA HPTVIFASAT TASPGATAAD
      241 LIGQPVVEVT EDGSPRGART VALWEPALRS DVIGEHGAPV RRSAGAEAAR VMADLIVEGA
      301 QTLTFVRSRR AAELTALGAR ARLVDIAPEL SDTVASYRAG YLAEDRSALH QALAEGQLRG
      361 LATTNALELG VDIAGLDAVV LAGFPGTVAS FWQQAGRSGR RGQGALVVLI ARDDPLDTYL
      421 VHHPAALLDK PVERVVIDPV NPHLLGPQLL CAATELPLDD AEVRSWGAVE VAESLVDDGL
      481 LRRRNGRYFP APGVKPHAAV DVRGAIGGQI VIVEAGTGRL LGSVGVGQAP AAAHPGAVYL
      541 HQGETYVVDS LDFQDGIAFV HAEDPGYATF AREVTDIAVT GTGERLVFGP VALGLVPVTV
      601 TNHVVGYLRR QLSGEVLDFV ELDMPEHTLP TTAVMYTITS DALVRSGIEA TRIPGSLHAA
      661 EHAAIGLLPL VASCDRGDIG GMSTATGPEG LPSVFVYDGY PGGAGFAERG FRRARTWLGA
      721 TAEAIEACEC PSGCPSCVQS PKCGNGNDPL DKAGAVRVLR LVLAELSEES P
//