LOCUS       SIU02283.1               241 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            transferase (possibly glycosyltransferase) protein.
ACCESSION   LT708304-3697
PROTEIN_ID  SIU02283.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3655"
                     /note="Mb3655, -, len: 241 aa. Equivalent to Rv3631, len:
                     241 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 241 aa overlap). Possible transferase
                     (EC 2.-.-.-), more specifically a glycosyltransferase (EC
                     2.4.-.-), equivalent to O69542|MLCB2548.24c|ML0207
                     PUTATIVE TRANSFERASE (PUTATIVE GLYCOSYLTRANSFERASE) from
                     Mycobacterium leprae (239 aa) FASTA scores: opt: 1303,
                     E(): 2.8e-72, (81.2% identity in 239 aa overlap). Also
                     similar to many dolichyl-phosphate mannose synthases and
                     hypothetical proteins e.g. O59263|PH1585 HYPOTHETICAL 34.6
                     KDA PROTEIN from Pyrococcus horikoshii (313 aa), FASTA
                     scores: opt: 472, E(): 1.2e-21, (36.65% identity in 232 aa
                     overlap); Q9V152|PAB1971 DOLICHYL-PHOSPHATE MANNOSE
                     SYNTHASE from Pyrococcus abyssi (287 aa), FASTA scores:
                     opt: 467, E(): 2.3e-21, (35.85% identity in 223 aa
                     overlap); Q58619|YC22_METJA|MJ1222 HYPOTHETICAL PROTEIN
                     from Methanococcus jannaschii (243 aa), FASTA scores: opt:
                     400, E(): 2.4e-17, (33.35% identity in 228 aa overlap);
                     O26474|MTH374 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE RELATED
                     PROTEIN from Methanobacterium thermoautotrophicum (291 aa)
                     FASTA scores: opt: 354, E(): 1.7e-14, (33.5% identity in
                     218 aa overlap); O26239|MTH136 DOLICHYL-PHOSPHATE MANNOSE
                     SYNTHASE from Methanobacterium thermoautotrophicum (220
                     aa), FASTA scores: opt: 345, E(): 4.8e-14, (33.5% identity
                     in 221 aa overlap); etc. Protein product from Mb3655
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3655 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4Q7"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4Q7"
BEGIN
        1 MASKMDTETH YSDVWVVIPA FNEAAVIGKV VTDVRSVFDH VVCVDDGSTD GTGDIARRSG
       61 AHLVRHPINL GQGAAIQTGI EYARKQPGAQ VFATFDGDGQ HRVKDVAAMV DRLGAGDVDV
      121 VIGTRFGRPV GKASASRPPL MKRIVLQTGA RLSRRGRRLG LTDTNNGLRV FNKTVADGLN
      181 ITMSGMSHAT EFIMLIAENH WRVAEEPVEV LYTEYSKSKG QPLLNGVNII FDGFLRGRMP
      241 R
//