LOCUS       SIU02279.1               461 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 D-alanyl-
            D-alanine carboxypeptidase (EC protein.
ACCESSION   LT708304-3693
PROTEIN_ID  SIU02279.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3651C"
                     /EC_number="3.4.16.4"
                     /note="Mb3651c, -, len: 461 aa. Equivalent to Rv3627c,
                     len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 461 aa overlap). Hypothetical ala-rich
                     protein which may have cleavable signal peptide at
                     N-terminal end. Equivalent to O69539|MLCB2548.20c|ML0211
                     HYPOTHETICAL 47.2 KDA PROTEIN from Mycobacterium leprae
                     (461 aa), FASTA scores: opt: 2295, E(): 3.5e-116, (76.2%
                     identity in 462 aa overlap); and C-terminal end shows
                     similarity with O05758|MLCB5.28c HYPOTHETICAL 24.1 KDA
                     PROTEIN from Mycobacterium leprae (225 aa), FASTA scores:
                     opt: 268, E(): 1.8e-07, (32.25% identity in 220 aa
                     overlap). Also similar (or with similarity) to various
                     proteins (notably penicillin binding proteins) e.g.
                     Q9X8I8|SCE9.15c HYPOTHETICAL 45.9 KDA PROTEIN from
                     Streptomyces coelicolor (459 aa) FASTA scores: opt: 707,
                     E(): 8.3e-31, (35.75% identity in 439 aa overlap);
                     Q9Z541|SC9B2.18c PUTATIVE CARBOXYPEPTIDASE from
                     Streptomyces coelicolor (451 aa), FASTA scores: opt: 450,
                     E(): 5.3e-17, (31.75% identity in 469 aa overlap);
                     Q9JVV4|NMA0665 PUTATIVE PEPTIDASE from Neisseria
                     meningitidis (serogroup A) (or Q9JY10|NMB1797 from
                     serogroup B) (469 aa), FASTA scores: opt: 269, E(): 3e-07,
                     (26.15% identity in 463 aa overlap); O85665|PBP3
                     PENICILLIN BINDING PROTEIN 3 from Neisseria gonorrhoeae
                     (469 aa), FASTA scores: opt: 265, E(): 4.9e-07, (31.85%
                     identity in 201 aa overlap); P45161|PBP4_HAEIN|DACB|HI1330
                     PENICILLIN-BINDING PROTEIN 4 PRECURSOR/PEPTIDASE (479 aa)
                     FASTA scores: opt: 230, E(): 3.8e-05, (27.9% identity in
                     394 aa overlap); P24228|PBP4_ECOLI|DACB|B3182
                     PENICILLIN-BINDING PROTEIN 4 PRECURSOR from Escherichia
                     coli strain K12 (477 aa), FASTA scores: opt: 166, E():
                     0.1, (28.2% identity in 408 aa overlap); etc. Protein
                     product from Mb3651c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3651c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y4U0"
                     /db_xref="InterPro:IPR000667"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4U0"
BEGIN
        1 MGPTRWRKST HVVVGAAVLA FVAVVVAAAA LVTTGGHRAG VRAPVPPPRP PTVKAGVVPV
       61 ADTAATPSAA GVTAALAVVA VDPDLGKLAG RITDALTGQE LWQRLDDVPL VPASTNKILT
      121 AAAALLTLDR QARISTRVVA GGQNPQGPVV LVGAGDPTLS AAPPGQDTWY HGAARIGDLV
      181 EQIRRSGVTP TAVQVDASAF SGPTMAPGWD PADIDNGDIA PIEAAMIDAG RIQPTTVNSR
      241 RSRTPALDAG RELAKALGLD PAAVTIASAP AGARQLAVVQ SAPLIQRLSQ MMNASDNVMA
      301 ECIGREVAVA INRPQSFSGA VDAVTSRLNT AHIDTAGAAL VDSSGLSLDN RLTARTLDAT
      361 MQAAAGPDQP ALRPLLDLLP IAGGSGTLGE RFLDAATDQG PAGWLRAKTG SLTAINSLVG
      421 VLTDRSGRVL TFAFISNEAG PNGRNAMDAL ATKLWFCGCT T
//